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Multifunctional Cu3BiS3-PEG-(Ce6-Gd<3+>)-FA nano composite material, and preparation method and application thereof

A nanocomposite material, cu3bis3-peg-ce6 technology, applied in wave energy or particle radiation treatment materials, drug combinations, pharmaceutical formulations, etc., can solve the problems of kidney toxicity, non-targeted imaging, and high cost

Inactive Publication Date: 2017-02-22
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the currently commonly used CT contrast agents in medicine are small molecules based on iodine, which have many limitations, such as inability to target imaging, short imaging time, toxicity to the kidneys, and high cost.

Method used

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  • Multifunctional Cu3BiS3-PEG-(Ce6-Gd&lt;3+&gt;)-FA nano composite material, and preparation method and application thereof
  • Multifunctional Cu3BiS3-PEG-(Ce6-Gd&lt;3+&gt;)-FA nano composite material, and preparation method and application thereof
  • Multifunctional Cu3BiS3-PEG-(Ce6-Gd&lt;3+&gt;)-FA nano composite material, and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Multifunctional Cu 3 BY 3-PEG-(Ce6-Gd 3+ )-FA nanocomposite preparation process is as follows:

[0051] (1) Cu(DEDC) 2 preparation

[0052] ① Dissolve 1.2094g of copper nitrate trihydrate in 80mL of distilled water, and disperse evenly to obtain copper nitrate solution;

[0053] ② Dissolve 2.2654g of sodium diethyldithiocarbamate trihydrate in 200mL of distilled water, and disperse evenly to obtain a DEDC solution;

[0054] ③ Slowly add the copper nitrate solution into the DEDC solution under stirring, and stir at room temperature for 0.5h, then let it stand for 4h, make it layered, then pour off the supernatant, and place the lower layer mixture in a centrifuge to centrifuge. The tan precipitate obtained after centrifugation was washed three times with distilled water and dried in vacuum to obtain Cu(DEDC) 2 .

[0055] (2) Bi(DEDC) 3 preparation

[0056] ① Dissolve 2.4427g of bismuth nitrate pentahydrate in 80mL of distilled water, and disperse evenly to obtai...

Embodiment 2

[0079] A multifunctional Cu 3 BY 3 -PEG-(Ce6-Gd 3+ )-FA nanocomposite material, its preparation method comprises the following steps:

[0080] (1) Bi(DEDC) with a molar ratio of 1:2 3 and Cu(DEDC) 2 Add to the mixed solvent A that is respectively 20 parts, 2 parts and 15 parts by volume of oleic acid, oleylamine and octadecene, so that every 1 mL of mixed solvent A contains 0.015gBi(DEDC) 3 , after mixing evenly, heat at 160°C for 10 minutes, then use a mixed solution of absolute ethanol and n-hexane in a volume ratio of 1:1 as a washing solution, and perform centrifugal washing to obtain oil-soluble Cu 3 BY 3 nanoparticles, the oil-soluble Cu 3 BY 3 The nanoparticles were dissolved in chloroform to obtain oil-soluble Cu with a mass concentration of 1 mg / mL 3 BY 3 Nanoparticle / chloroform solution;

[0081] (2) DSPE-PEG and DSPE-PEG-NH with a mass ratio of 3:1 were respectively 2 Dissolved in chloroform to obtain DSPE-PEG / DSPE-PEG-NH with a mass concentration of 1.2m...

Embodiment 3

[0088] A multifunctional Cu 3 BY 3 -PEG-(Ce6-Gd 3+ )-FA nanocomposite material, its preparation method comprises the following steps:

[0089] (1) Bi(DEDC) with a molar ratio of 1:4 3 and Cu(DEDC) 2 Add to the mixed solvent A that is respectively 20 parts, 4 parts and 25 parts by volume of oleic acid, oleylamine and octadecene, so that every 1 mL of mixed solvent A contains 0.03gBi(DEDC) 3 , after mixing evenly, heat at 180°C for 5min, and then use the mixed solution of absolute ethanol and n-hexane in a volume ratio of 2:1 as the washing solution, and perform centrifugal washing to obtain oil-soluble Cu 3 BY 3 nanoparticles, the oil-soluble Cu 3 BY 3 The nanoparticles were dissolved in chloroform to obtain an oil-soluble Cu with a mass concentration of 3 mg / mL 3 BY 3 Nanoparticle / chloroform solution;

[0090] (2) DSPE-PEG and DSPE-PEG-NH with a mass ratio of 4:1 were respectively 2 Dissolved in chloroform to obtain DSPE-PEG / DSPE-PEG-NH with a concentration of 10 mg...

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Abstract

The invention relates to a multifunctional Cu3BiS3-PEG-(Ce6-Gd<3+>)-FA nano composite material, and a preparation method and application thereof. The preparation method comprises the following steps: preparing oil-soluble Cu3BiS3 nanoparticles by using as Bi(DEDC)3 and Cu(DEDC)2 precursors, sequentially preparing DSPE-PEG / DSPE-PEG-NH2-modified water-soluble Cu3BiS3 nanoparticles, a Cu3BiS3-PEG-Ce6 water solution and a Cu3BiS3-PEG-(Ce6-Gd<3+>) water solution, and finally, coupling FA to the Cu3BiS3-PEG-(Ce6-Gd<3+>) to prepare the multifunctional Cu3BiS3-PEG-(Ce6-Gd<3+>)-FA nano composite material. The composite material is used for preparing CT (computerized tomography) contrast agents, MRI (magnatic resonance imaging) contrast agents, photothermal converters or photosensitive drugs. Compared with the prior art, the composite material can integrate photothermal and photodynamic treatment means to implement photothermal / photodynamic synergic treatment on cancers, and can also be used as MRI and CT contrast agents to implement bimodal imaging. The research on multiple molecule image probes on one molecule indicates that the composite material has wide application prospects in the field of biomedicine.

Description

technical field [0001] The invention belongs to the technical field of functional nanocomposite materials, and relates to a multifunctional Cu 3 BY 3 -PEG-(Ce6-Gd 3 + )-FA nanocomposite material and its preparation method and application. Background technique [0002] Photodynamic therapy (PDT) is a new approach to treat tumor diseases using photosensitizing drugs and laser activation. Irradiating the tumor site with light of a specific wavelength can activate the photosensitive drug selectively accumulated in the tumor tissue, and then trigger a photochemical reaction to destroy the tumor. The photosensitizing drug in the new generation of photodynamic therapy will transfer energy to the surrounding oxygen to generate highly active singlet oxygen. Singlet oxygen can oxidize with nearby biomacromolecules to produce cytotoxicity and kill tumor cells. Compared with traditional tumor therapy, the advantage of PDT is that it can carry out accurate and effective treatment, ...

Claims

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Application Information

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IPC IPC(8): A61K49/12A61K49/04A61K41/00A61K47/60A61K47/54A61P35/00
CPCA61K41/0052A61K41/0057A61K49/04A61K49/12
Inventor 吴惠霞蔡东东张忆雪王研科杨仕平
Owner SHANGHAI NORMAL UNIVERSITY
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