Preparation method of wild antheraea pernyi silk fibroin composite maltodextrin active stent material

Abstract

The invention provides a preparation method of a wild antheraea pernyi silk fibroin composite maltodextrin active stent material. The composite stent material takes wild antheraea pernyi silk fibroin and maltodextrin as main raw materials; the wild antheraea pernyi silk fibroin can promote fiber cell adhesion; the maltodextrin has functions of material modifier, pore-foaming agents, cell nutrients and neutrophil chemotactic agents; pore size distribution and porosity of the material are adjusted by the aid of phase separation-ultrasonic leaching hole technology in the preparation process of the material, mechanical property and degradation property of the material are favorably and flexibly adjusted, and matching of stent degradation rate and cell growth rate is realized; the preparation method is simple in process, short in production circle, high in clinical application value and especially suitable for preparation of artificial skin.

Description

technical field [0001] The invention relates to the field of tissue engineering scaffold materials, in particular to a method for preparing an active scaffold material compounded with tussah silk fibroin and maltodextrin. Background technique [0002] Tissue engineering is to make degradable biomaterials into scaffolds of specific shape and pore size. Under the action of growth factors, combined with living cells from specific tissue sources, a biologically active implant is pre-built after in vitro culture, and then implanted into the body. , to repair or replace defective tissues or organs, and finally form corresponding tissues or organs and perform corresponding engineering. Therefore, the core of tissue engineering is living cells and scaffolding materials for cells to carry out life activities, as well as their mutual use. Scaffold material is the most basic structure of tissue engineered tissue, providing cells with a place to obtain nutrients, gas exchange, excrete ...

AI Technical Summary

Problems solved by technology

However, these pore-forming methods are all one-time pore-forming and have poor flexibility; moreover, the finished products prepared by the porogen method reported at present do not contain porogen, and are often not environmentally degradable, increasing the burden on environmental protection

For example: the patent document with the publication number CN105457096A discloses a preparation method of a biocompatible and degradable tussah fibroin protein tissue engineering scaffold material. The invention introduces the freeze-drying method, porogen method and electrospinning There are three preparation methods, but they are all one-time pore-forming, poor flexibility, and most of the degradable polymers blended with silk fibroin are synthetic polymers, which are not only non-nutritional and immune-promoting, but also have an adjustable degradation cycle. Difficult to meet clinical needs