Inorganic-inorganic nano hybrid material of bimodal mesoporous core-shell structure as well as preparation method and application of inorganic-inorganic nano hybrid material

A core-shell structure and hybrid material technology, applied in the field of nano-hybrid materials and their preparation, can solve the problems of component stability, insufficient consistency, cumbersome preparation methods, and difficult industrialization, and achieve biomedical application prospects. The effect of broad, few process steps and easy process control

Active Publication Date: 2017-05-10
SHANGHAI UNIV
View PDF2 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current commercial magnetic resonance contrast agents have the disadvantages of long relaxation time and short cycle period, and the sta

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Inorganic-inorganic nano hybrid material of bimodal mesoporous core-shell structure as well as preparation method and application of inorganic-inorganic nano hybrid material
  • Inorganic-inorganic nano hybrid material of bimodal mesoporous core-shell structure as well as preparation method and application of inorganic-inorganic nano hybrid material
  • Inorganic-inorganic nano hybrid material of bimodal mesoporous core-shell structure as well as preparation method and application of inorganic-inorganic nano hybrid material

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0029] Example 1

[0030] The platinum-gadolinium nano-hybrid material with a double mesoporous core-shell structure and its preparation method provided in this embodiment include the following steps:

[0031] (1) Using N,N-dimethylhexadecylammonium bromide sodium acetate (OTAB-Na) as a surfactant, using ascorbic acid to reduce chloroplatinic acid to synthesize mesoporous inorganic platinum nanoparticles: 80 mg surface The active agent N,N-dimethylhexadecylammonium bromide sodium acetate (OTAB-Na) was added to 10mL of deionized water, heated to 70 ℃ to dissolve, and then added 2mL0.01mol / L chloroplatinic acid aqueous solution and 2mL0. 2mol / L fresh ascorbic acid aqueous solution, stirred for 3h, centrifuged, washed, and the product was dissolved in deionized water to form a mesoporous platinum nanoparticle dispersion.

[0032] (2) Using cetyltrimethylammonium bromide (CATB) as a surfactant, wrap a mesoporous silica shell on the surface of mesoporous inorganic nanoparticles, and then...

Example Embodiment

[0039] Example 2

[0040] The palladium-gadolinium nano-hybrid material with double mesoporous core-shell structure and its preparation method, material and application provided in this embodiment are basically the same as those in embodiment 1, except that it includes the following steps:

[0041] (1) Using N,N-dimethylhexadecylammonium bromide sodium acetate (OTAB-Na) as a surfactant, using ascorbic acid to reduce palladium chloride to synthesize mesoporous inorganic palladium particles: 100mg of surface active (OTAB-Na) was added to 10mL deionized water, heated to 50℃ to dissolve, then 1mL 0.01mol / L palladium chloride aqueous solution and 1mL 0.2mol / L fresh ascorbic acid aqueous solution were added, stirred for 1h, centrifuged, washed, and the product dissolved In deionized water, a dispersion of mesoporous palladium nanoparticles is formed.

[0042] (2) Using cetyltrimethylammonium bromide (CATB) as a surfactant, wrap a mesoporous silica shell on the surface of mesoporous inorga...

Example Embodiment

[0045] Example 3

[0046] The gold-gadolinium nano-hybrid material with double mesoporous core-shell structure and its preparation method, material and application provided in this embodiment are basically the same as those in Embodiment 1 or 2, except that it includes the following steps:

[0047] (1) Using N,N-dimethylhexadecylammonium bromide sodium acetate (OTAB-Na) as a surfactant, using ascorbic acid to reduce chloroauric acid to synthesize mesoporous inorganic gold particles: 90mg of surface active (OTAB-Na) was added to 10mL deionized water, heated to 100℃ to dissolve, then 1.5mL 0.01mol / L chloroauric acid aqueous solution and 1.5mL 0.2mol / L fresh ascorbic acid aqueous solution were added, stirred for 2h, centrifuged, washed, The product is dissolved in deionized water to form a dispersion of mesoporous gold nanoparticles.

[0048] (2) Using cetyltrimethylammonium bromide (CATB) as a surfactant, wrap a mesoporous silica shell on the surface of mesoporous inorganic nanopartic...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
The average particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention discloses an inorganic-inorganic nano hybrid material of a bimodal mesoporous core-shell structure as well as a preparation method and an application of the inorganic-inorganic nano hybrid material. The bimodal mesoporous inorganic-inorganic nano hybrid material of the core-shell structure is prepared by the following steps: firstly, with the presence of a surfactant, reducing metal salt by virtue of ascorbic acid, so that mesoporous inorganic nanoparticles are obtained; then, covering the surface of hexadecyl trimethyl ammonium bromide, which serves as a surfactant, with a layer of mesoporous silicon dioxide; covalently grafting diethyltriamine pentaacetic acid after modifying a mesoporous silicon dioxide shell layer by virtue of amino; and finally, coordinating with metal ions, so that the bimodal mesoporous inorganic-inorganic nano hybrid material of the core-shell structure is obtained. The prepared material has the core-shell material, wherein a core is constituted by the mesoporous inorganic nanoparticles and a shell is formed by the mesoporous silicon dioxide shell layer, and the surface of the mesoporous silicon dioxide shell layer is hybridized and modified by virtue of inorganic metals. The inorganic-inorganic nano hybrid material has the advantages of being uniform in dimension, good in biocompatibility and the like, and the inorganic-inorganic nano hybrid material is high in optical stability, high in photo-thermal conversion rate and high in magnetic resonance imaging resolution ratio; and integration of magnetic resonance imaging and photo-thermal therapy can be achieved.

Description

technical field [0001] The invention relates to a nano hybrid material and its preparation method and application, in particular to a core-shell structure double mesoporous inorganic-inorganic nano hybrid material and its preparation method and application. Background technique [0002] In recent years, cancer is one of the important causes of human death, and the detection and treatment of tumors has always been a major problem that plagues people. At present, the main treatment methods are chemotherapy and radiotherapy, but their serious side effects cannot be ignored. The detection and targeted treatment of tumors are even more urgent. Photothermal therapy uses near-infrared light excitation, which has a large penetration depth. It is an emerging and effective treatment method in recent years. However, some photothermal reagents that have been reported have the disadvantages of poor photostability and low photothermal conversion rate. Therefore, it is of great significa...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K49/18A61K41/00A61K47/69A61K47/54A61K47/52A61P35/00
CPCA61K41/0052A61K49/1833
Inventor 孙丽宁施利毅赵磊李海宏刘金亮赵慧君
Owner SHANGHAI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap