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High-skin-retention glabridin nano composition as well as preparation method and application thereof

A nano-composite, the technology of glabridin, which is applied in the directions of skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problem of inability to achieve skin care effects, poor skin permeability and retention of glabridin, and reduce cosmetics. Stability and other issues, to achieve the effect of increasing skin retention, increasing skin penetration, and improving skin permeability

Active Publication Date: 2017-05-24
WUHAN BEST CARRIER NANO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of glabridin in cosmetics has the following three defects: one is that the solubility of glabridin is very small and its water dispersibility is poor, and the mass percentage of active ingredients in common glabridin cosmetics is only 0.05 to 0.2%. , low content of glabridin can not achieve the skin care effect; second, glabridin is easy to oxidize and change color, which reduces the stability of cosmetics; third, the existing marketed products are usually creams and emulsions, with large particle size, skin permeability and Poor retention, affecting skin care effect
[0004] Chinese invention patent CN104367483A discloses a nanoemulsion loaded with glabridin and its preparation method. The prepared nanoemulsion has the advantages of high stability and good water dispersibility, but the average particle size of the prepared nanoemulsion is 130-140nm, and the particle size The diameter is larger, and the skin permeability and retention of glabridin are poor
[0005] Chinese invention patent CN103976892A discloses a glabridin microemulsion and its preparation method. The prepared glabridin microemulsion has a high encapsulation efficiency and a suitable particle size. The method is cumbersome, and the total amount of finished products in a single preparation is small, which is not suitable for industrialization and large-scale production; secondly, the basis for judging the end point of the preparation method is that the solution changes from turbid to clear, and the end point evaluation standard cannot be quantified
[0006] Chinese invention patent CN104306352A discloses a glabridin microcapsule and its preparation method. The prepared microcapsule has good stability, dissolution rate and fluidity, and the average particle size is 60-80nm, which can achieve sustained release, The purpose of controlled release, but the preparation method of the present invention uses organic solvents dichloromethane and petroleum ether, and toxic substances dichloromethane and petroleum ether will remain in the finished product, which increases the safety risk of using glabridin microcapsules

Method used

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  • High-skin-retention glabridin nano composition as well as preparation method and application thereof
  • High-skin-retention glabridin nano composition as well as preparation method and application thereof
  • High-skin-retention glabridin nano composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] (1) Preparation of oil phase: 2.0% triglyceride behenate, 1.0% caprylic triglyceride, 0.5% octyldodecyl alcohol, melted in a water bath at 65°C; add 0.1% glabridin after melting, Mix well and set aside;

[0046] (2) Water phase: add 0.5% vitamin E polyethylene glycol succinate and 10.0% glycerin to 85.9% purified water, stir and dissolve in a water bath at 65°C, and set aside;

[0047] (3) Preparation of micron-scale dispersion: add the oil phase prepared in step (1) dropwise to the water phase prepared in step (2), and keep stirring, and then 5000rpm high-speed shear emulsification for 10min to make a micron-scale dispersion ;

[0048] (4) Preparation of nano-composition: the micron-sized dispersion prepared in step (3) was circulated twice through high-pressure homogenization at 1200 bar to obtain a glabridin nano-composition. The particle diameter of the glabridin nano composition is 65.2nm, and the encapsulation efficiency is 81.7%.

Embodiment 2

[0050] (1) Prepare the oil phase: 4.0% soybean lecithin, 1.0% squalene, 1.0% caprylic capric glyceride, 0.5% octyl dodecanol, melt in a water bath at 70°C; add 0.5% glabridin after melting , mix well, set aside;

[0051] (2) Prepare the water phase: add 1.0% vitamin E polyethylene glycol succinate and 5.0% 1,3-butanediol to 87.0% purified water, stir and dissolve in a water bath at 70°C, and set aside;

[0052] (3) Preparation of micron-scale dispersion: add the oil phase prepared in step (1) dropwise to the water phase prepared in step (2), and keep stirring, then 8000rpm high-speed shear emulsification for 3min to make a micron-scale dispersion ;

[0053] (4) Preparation of nano-composition: the micron-sized dispersion prepared in step (3) was circulated three times through a high-pressure micro-jet at 1200 bar to obtain a glabridin nano-composition. The particle size of the glabridin nano composition is 57.4nm, and the encapsulation efficiency is 78.9%.

Embodiment 3

[0055] (1) Preparation of oil phase: 2.0% glyceryl monostearate, 2.0% glyceryl laurate, 2.0% isopropyl myristate, 1.0% soybean oil, 1.0% octyldodecyl alcohol, make in a water bath at 90°C Melting; after melting, add 1.0% glabridin, mix evenly, and set aside;

[0056] (2) Prepare the water phase: add 1.5% vitamin E polyethylene glycol succinate, 7.0% glycerin, and 9.0% 1,2-pentanediol to 73.5% purified water, stir and dissolve in a water bath at 90°C, and set aside;

[0057] (3) Preparation of micron-scale dispersion: drop the oil phase prepared in step (1) into the water phase prepared in step (2), and keep stirring, 6000rpm high-speed shear emulsification for 5min to make a micron-scale dispersion;

[0058] (4) Preparation of nano-composition: the micron-sized dispersion prepared in step (3) was circulated 10 times through high-pressure homogenization at 500 bar to obtain a glabridin nano-composition. The particle size of the glabridin nano composition is 51.9nm, and the enc...

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Abstract

The invention relates to a high-skin-retention glabridin nano composition as well as a preparation method and application thereof. The high-skin-retention glabridin nano composition comprises the following components in percentage by mass: 0.1-6.0% of glabridin, 2.0-10.0% of solid lipid, 1.0-6.0% of liquid lipid, 0.5-5.0% of octyldodecanol, 0.5-5.0% of vitamin E succinic acid macrogol ester, 5.0-20.0% of polyol and the balance of purified water, wherein oil phase prepared from the glabridin, the solid lipid, the liquid lipid and the octyldodecanol is dropped into water phase prepared from the vitamin E succinic acid macrogol ester, the polyol and the purified water, and the mixture is treated by using equipment for high-speed shearing emulsification, high-pressure homogenization or high-pressure micro jetting. The high-skin-retention glabridin nano composition is large in drug loading capacity, is capable of promoting the glabridin to penetrate through skin and retain the glabridin in high concentration for a long time, and in addition is good in stability, high in security, simple and easy in preparation method control and applicable to industrial production.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a high-skin retention glabridin nano composition, a preparation method and application thereof. Background technique [0002] Glabridin is one of the main flavonoid components extracted from the root of Glycyrrhizae glabra, which can be used as a raw material for cosmetics and is known as "whitening gold". Glabridin can penetrate deep into the skin and maintain high activity, anti-inflammatory, whitening and high-efficiency anti-oxidation, effectively inhibit the activity of various enzymes in the process of melanin production, especially inhibit the activity of tyrosinase, and also have anti-rough and anti-bacterial properties Efficacy is considered to be a whitening ingredient with good curative effect, comprehensive functions and high safety. It is the main functional ingredient of high-end whitening cosmetics in the world. Glabridin is widely used by Japanese a...

Claims

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Application Information

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IPC IPC(8): A61K8/86A61K8/49A61K8/55A61K8/63A61K8/37A61K8/34A61Q19/02
CPCA61K8/342A61K8/37A61K8/498A61K8/553A61K8/63A61K8/86A61K2800/413A61K2800/522A61K2800/591A61Q19/02
Inventor 刘卫许琦郭凤凤杨达峰
Owner WUHAN BEST CARRIER NANO TECH
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