Electrospun nanofiber with drug gradient distribution characteristics and preparation method thereof

A gradient distribution, drug-loaded nanotechnology, applied in the field of materials science, can solve the problems of poor drug slow and controlled release performance, and achieve the effect of clear structure, good linearity, and smooth fiber surface

Inactive Publication Date: 2017-06-06
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the above-mentioned technical problems in the prior art, the present invention provides an electrospun nanofiber with drug gradient distribution characteristics and a preparation method thereof,

Method used

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  • Electrospun nanofiber with drug gradient distribution characteristics and preparation method thereof
  • Electrospun nanofiber with drug gradient distribution characteristics and preparation method thereof
  • Electrospun nanofiber with drug gradient distribution characteristics and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: Implementation of three-stage coaxial electrospinning process

[0021] Put 36 grams of vinyl acetate cellulose into 300 grams of a mixed solvent composed of acetone and N,N-dimethylformamide at a mass ratio of 3:1 to prepare a mother liquor with good spinning performance. Divide the above mother liquor into three parts, add 1 g, 3 g and 5 g of the drug chlorpheniramine maleate respectively, and stir to form a transparent eutectic solution, which is used as the inner layer, the middle layer and the outer layer respectively. layer of working fluid. Put the above three working fluids into the injectors 10, 9, and 8 of the inner core layer, middle layer and outer layer working fluid of the three-stage coaxial electrospinning respectively, and connect the fluids of each layer to the three-stage coaxial spinning head 5 , connect the high-voltage spinning head and the high-voltage electrostatic generator 1. The three-stage coaxial high-voltage electrospinning p...

Embodiment 2

[0024] Example 2: Characterization analysis of nanofiber morphology and structure with drug gradient distribution characteristics

[0025] Field emission scanning electron microscopy (FESEM) was used to observe the surface of the fiber prepared in Example 1 after spraying gold, and the results were as follows image 3 shown. The prepared fiber exhibits a good linear state, no beading structure occurs, the fiber surface is smooth, and the fiber accumulation is uniform. The diameter is 640 ± 130 nm, the distribution is relatively uniform, and the diameter distribution is relatively concentrated.

[0026] The internal structure of the prepared fiber was observed by high-resolution transmission electron microscope (TEM), and the results were as follows: Figure 4 As shown, the inner / middle / outer layer structure of nanofibers is clear, and the outer layer has a lower gray scale due to its low drug content and thin thickness, while the inner layer has a large drug content and larg...

Embodiment 3

[0028] Example 3: The sustained and controlled release performance of ibuprofen provided by nanofibers with drug gradient distribution characteristics

[0029] According to the 2015 edition of Chinese Pharmacopoeia Appendix ⅩD Release Test Method 2, the drug-loaded nanofibers obtained above were subjected to an in vitro dissolution test using an RCZ-8A intelligent dissolution tester. The control speed is 50rpm, the temperature is 37±0.1℃, and the dissolution medium is 900mL pH7.0 phosphate buffer solution. Under these conditions, the drug release performance of nanofibers with drug gradient distribution characteristics in vitro is investigated. Sampling 5mL at the scheduled time to obtain a sample of the dissolution solution, and immediately replenish the same volume of isothermal fresh medium. After appropriate dilution of the sample, at λ max = 264 nm, the ultraviolet-visible spectrophotometer was used for ultraviolet measurement, and the dissolution amount and cumulative d...

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Abstract

The invention provides a drug-loaded nanofiber with drug gradient distribution characteristics. The nanofiber comprises an inner core layer, the periphery of the inner core layer is provided with an interlayer, the periphery of the interlayer is provided with an outer surface layer, the inner score layer, the interlayer and the outer surface layer extend coaxially, the inner core layer, the interlayer and the outer surface layer all contain drugs, and drug concentration increases in sequence from outside to inside in gradient distribution. The invention further provides a preparation method of the nanofiber with the drug gradient distribution characteristics and provides a device for achieving the method. According to the preparation method of the nanofiber with the drug gradient distribution characteristics, the preparation process is simple, and effective with single step, the prepared nanofiber inner core layer, interlayer and outer layer are clear in structure, and the nano is small in diameter, good in linearity, even in diameter distribution and smooth in fiber surface. The drug gradient distribution method is capable of providing an effective implementation method for the design and preparation of a great number of drug slow and controlled materials.

Description

technical field [0001] The invention belongs to the field of materials science, and relates to a technology for establishing a structure-activity relationship of a novel nano-level substance, in particular to an electrospun nanofiber with drug gradient distribution characteristics and a preparation method thereof. Background technique [0002] High-voltage electrospinning technology (electrospinning) is a top-down nano-manufacturing technology. The jet formed by overcoming the liquid surface tension and viscoelastic force of the droplet at the tip of the nozzle is overcome by an external electric field force. Under the joint action of Coulomb force and surface tension, the atomized liquid jet is bent, stretched, and split by high frequency, and is stretched tens of millions of times within tens of milliseconds. After the solvent is volatilized or the melt is cooled, it is obtained at the receiving end. nanoscale fibers. This technology has simple process, convenient opera...

Claims

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Application Information

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IPC IPC(8): D01D5/00D01D5/34D01F2/28D01F1/10
CPCD01D5/0069D01D5/34D01F1/10D01F2/28
Inventor 余灯广张瑶瑶张玲玲郑招斌张曼
Owner UNIV OF SHANGHAI FOR SCI & TECH
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