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Preparation method of polyamide-amine grafted graphene oxide coated biological small molecule adsorbent

A technology of small biological molecules and graphene coating, applied in chemical instruments and methods, alkali metal oxides/hydroxides, alkali metal compounds, etc., can solve the problems of insignificant adsorption effect of biological small molecules, and achieve low cost , good biocompatibility, long service life

Inactive Publication Date: 2017-10-20
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far, neither polymer microspheres nor graphene oxide have significant adsorption effects on small biomolecules.

Method used

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  • Preparation method of polyamide-amine grafted graphene oxide coated biological small molecule adsorbent
  • Preparation method of polyamide-amine grafted graphene oxide coated biological small molecule adsorbent

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[0030] The invention discloses a preparation method of a polyamide-amine grafted graphene oxide-coated biological small molecule adsorbent. The specific experimental steps are as follows:

[0031] a. Preparation of monodisperse polystyrene microsphere seeds by dispersion method

[0032] Using 95% ethanol as solvent, styrene as monomer, adding polystyrene pyrrolidone stabilizer and azobisisobutyronitrile initiator, and generating monodisperse linear polystyrene microsphere seeds through radical polymerization under nitrogen protection. Observation by a scanning electron microscope shows that the prepared seeds are monodisperse uniform particles with a diameter of 2 microns.

[0033] b. Preparation of styrene-divinylbenzene-glycidyl methacrylate microspheres by seed swelling method

[0034] The prepared linear polystyrene seed is activated and mixed with dibutyl phthalate to swell, and then added with glycidyl methacrylate monomer, divinylbenzene crosslinking agent, benzoyl per...

Embodiment 1

[0044] Use 95% ethanol aqueous solution as the base, add 5-30mL styrene monomer, 0.5-1g azobisisobutyronitrile initiator, 0.5-4g polyvinylpyrrolidone stabilizer, react at 70°C overnight to obtain a particle size of 1-3 μm For monodisperse linear polystyrene seeds, disperse the seeds into 2% sodium dodecyl sulfate solution for later use. Take 2ml of the prepared seeds and dibutyl phthalate, dissolve them in 50ml of sodium dodecylsulfonate solution, and swell overnight. Add styrene (2-5%, v / v), divinylbenzene (4-10%, v / v), glycidyl methacrylate (0.4-1.2%, v / v) , sodium dodecylsulfonate (0.2-0.5%, m / v), benzoyl peroxide (0.1-0.2%, m / v), toluene (5-15%, v / v) and polyvinyl alcohol (0.5-5%, m / v) mixed solution is swollen and heated to react to obtain polystyrene-divinylbenzene-glycidyl methacrylate microspheres with a diameter of 5-8 μm, and the reaction temperature is 60-85°C. The stirring speed is 100-300 rpm, and the reaction time is 12-48h.

[0045] The graphene oxide used in...

Embodiment 2

[0049] Use 95% ethanol aqueous solution as the base, add 5-30mL styrene monomer, 0.5-1g azobisisobutyronitrile initiator, 0.5-4g polyvinylpyrrolidone stabilizer, react at 70°C overnight to obtain a particle size of 1-3 μm For monodisperse linear polystyrene seeds, disperse the seeds into 2% sodium dodecyl sulfate solution for later use. Take 2 mL of the prepared seeds and dibutyl phthalate and dissolve them in 50 mL of sodium dodecyl sulfate solution, and swell overnight. Add styrene (2-5%, v / v), divinylbenzene (4-10%, v / v), glycidyl methacrylate (0.4-1.2%, v / v) , sodium dodecylsulfonate (0.2-0.5%, m / v), benzoyl peroxide (0.1-0.2%, m / v), toluene (5-15%, v / v) and polyvinyl alcohol (0.5-5%, m / v) mixed solution is swollen and heated to react to obtain polystyrene-divinylbenzene-glycidyl methacrylate microspheres with a diameter of 5-8 μm, and the reaction temperature is 60-85°C. The stirring speed is 100-300 rpm, and the reaction time is 12-48h.

[0050] The graphene oxide use...

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Abstract

The invention discloses a preparation method of a polyamide-amine grafted graphene oxide coated biological small molecule adsorbent, a styrene-divinylbenzene-glycidyl methacrylate polymer microsphere is used as a matrix of the adsorbent, the surface of the matrix is coated with graphene oxide prepared by Hummer method for derivatization of a composite matrix material, a polyamide-amine dendrimer is grafted onto the surface of the matrix by chemical grafting method, and the biological small molecule adsorbent is prepared by use of 1,4-Butanediol diglycidyl ether for further modification. The styrene-divinylbenzene-glycidyl methacrylate polymer microsphere is used as the matrix of the adsorbent, and the adsorbent has the advantages of simple process, low cost, long service life, uniform particle size, good chemical stability and wider pH tolerance range.

Description

technical field [0001] The invention relates to a method for preparing an adsorbent, in particular to a method for preparing a polyamide-amine grafted graphene oxide-coated adsorption material for small biological molecules. Background technique [0002] Based on the requirements of stability and mechanical strength, many adsorption materials are based on polymer microspheres. However, most polymer microspheres are polymerized from monomers such as polystyrene, divinylbenzene, and methyl acrylate. After the polymerization reaction, only a small amount of active groups remain on the surface, and further derivatization is difficult. With the development of carbon nanomaterials, the two-dimensional carbon material graphene oxide has received more and more attention. Compared with other carbon nanomaterials, graphene oxide not only has a large number of active oxygen-containing functional groups on the surface, but also has a unique large π electron cloud conjugated structure....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30C08F212/08C08F220/32C08F212/36C08J3/12C08J9/14C08J7/06C08G83/00
CPCB01J20/265B01J20/28021C08F212/08C08G83/003C08G83/004C08J3/12C08J7/06C08J9/141C08J2325/08C08F220/325C08F212/36
Inventor 郭丹丹朱岩
Owner ZHEJIANG UNIV
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