Preparation method of ethyl lauroyl arginate hydrochloride

Abstract

The invention discloses a preparation method of ethyl lauroyl arginine hydrochloride, which belongs to the technical field of organic synthesis. The method comprises: reacting L-arginine hydrochloride with lauroyl chloride in a mixed solvent composed of water and organic solvent A, after the reaction is completed, adjusting the pH value to 5-9, centrifuging and drying to obtain lauroyl arginine; React lauroyl arginine with ethanol and thionyl chloride, and evaporate to dryness to obtain the crude product after the reaction is completed; dissolve the crude product in organic solvent B, add alkaline aqueous solution to adjust the pH value to 5-8, stir, stand still, and take The organic layer was cooled to crystallize, centrifuged and dried to obtain the refined product of ethyl lauroyl arginate hydrochloride. The preparation method provided by the invention has the advantages of simple operation, few by-products, easy separation, easy drying and easy crushing, etc., and the main impurities in the product are effectively removed during the preparation process, and high-purity fine particle lauroyl arginine B can be obtained. Ester hydrochloride, suitable for large-scale production, the product is widely used in food and cosmetic industries.

Description

technical field [0001] The invention belongs to the field of organic synthesis, in particular to a preparation method of ethyl lauroyl arginine hydrochloride, in particular to a preparation method of ethyl lauroyl arginine hydrochloride which can be used as a preservative for food and cosmetics . Background technique [0002] Lauroyl arginine ethyl ester hydrochloride is a new type of antibacterial agent. According to research, lauroyl arginine ethyl ester hydrochloride has a strong effect on Gram-negative and Gram-positive bacteria, yeast and mold. antibacterial effect. Its mechanism of action is that ethyl lauroyl arginate hydrochloride is a cationic surfactant, which can affect the negatively charged membrane protein and enzymatic mechanism in the bacterial cell membrane, change the permeability of the cell membrane, and achieve the effect of inhibiting microorganisms. The effect of growing or inactivating microorganisms. [0003] Lauroyl arginine ethyl ester hydrochlo...

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Problems solved by technology

This method uses arginine hydrochloride instead as a raw material, and the cost is lower, which is beneficial to industrialized production, but the reaction is carried out in a strong alkali aqueous solution, and lauroyl chloride is easily hydrolyzed into lauric acid under alkaline aqueous conditions, and lauroyl arginine The crystal form of ethyl acetate hydrochloride is not good in water, and the wet product after centrifugation contains a large amount of water, and the remaining raw materials and impurities produced during the reaction process include arginine, ethyl arginine, ethyl laurate and sodium chloride etc. will remain in the product with water, resulting in low content and purity of the product (purity is only about 90%), plus lauroyl arginine ethyl ester hydrochloride has a melting point of 50-58°C and is separated from water Lauroyl arginine ethyl ester hydrochloride will melt when the temperature is slightly higher when it is dried, and the water removal efficiency is very low at low temperature, so it is difficult to dry

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