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Chinese herbal compound microemulsion gel emplastrum, and its preparation method and application

A technology of microemulsion gel and plaster, which can be used in pharmaceutical formulations, non-central analgesics, antipyretics, etc., can solve the problems of easy skin pulling, loss of active ingredients, dull ointment, etc., to avoid active Effects of ingredients and moisture loss, improving formulation stability, and promoting transdermal penetration

Inactive Publication Date: 2017-12-01
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

⑤It is easy to pull the skin during the peeling process, causing skin flushing, fever, and even allergies
However, the traditional preparation methods of rubber plaster mainly include solvent method and hot pressing method, both of which need to be completed at a higher temperature, which will inevitably cause the loss of active ingredients and affect the efficacy of the drug.
Moreover, the solvent method consumes a large amount of energy resources, the production process has great potential safety hazards, gasoline is extremely flammable, and a large amount of gasoline volatilizes during the drying process, which pollutes the environment and is not conducive to the labor protection of production workers.
The rubber plaster prepared by hot pressing has the disadvantages of not bright paste surface, weak stickiness, and residue on the skin after pasting.

Method used

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  • Chinese herbal compound microemulsion gel emplastrum, and its preparation method and application
  • Chinese herbal compound microemulsion gel emplastrum, and its preparation method and application
  • Chinese herbal compound microemulsion gel emplastrum, and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Example 1 Preparation of Huoxue Zhitong Extract

[0079] Huoxue Zhitong ointment (rubber ointment) has been included in the Pharmacopoeia (2010 edition, one part 957 pages, 2015 edition one part, 1294 pages), its prescription and extract preparation method are as follows:

[0080]

[0081] In addition to the menthol, borneol, camphor, methyl salicylate, and belladonna liquid extract in the prescription of Huoxue Zhitong ointment, the other twenty-three medicinal materials such as Angelica dahurica are crushed into coarse powder, and 90% ethanol is used as a solvent, soaked, and infiltrated , collect the percolation liquid, recover ethanol and concentrate it into a clear paste with a relative density of 1.2634 (25°C), add belladonna liquid extract, stir well, and obtain the blood-activating and pain-relieving extract. Above-mentioned menthol, borneol, camphor, methyl salicylate are standby.

Embodiment 2

[0082] Embodiment 2 Preparation example 1 of the microemulsion gel plaster for promoting blood circulation and relieving pain of the present invention

[0083] Prescription 1 (according to 100 grams)

[0084]

[0085]

[0086] Weigh menthol, borneol, camphor, and methyl salicylate according to the prescription in Example 1, first take camphor, menthol, and borneol, mix and grind until partially liquefied, then add methyl salicylate and stir to completely dissolve, as a mixed oil phase .

[0087] Weigh 3.82g of the mixed oil phase, 10.23g of RH40, and 5.09g of PEG400, stir at 20-35°C for 10 minutes at a stirring speed of 300-500 rpm, add water slowly, and stir for 10 minutes to obtain a blank microemulsion.

[0088] Add 1.92 g of the blood-activating and pain-relieving extract prepared in Example 1 into the blank microemulsion, and stir to balance for 30 minutes to obtain the blood-activating and pain-relieving microemulsion.

[0089] Weigh 4.00 g of carbomer and 1.00 g...

Embodiment 3 preparation example 2

[0091] Prescription 2 (according to 100 grams)

[0092]

[0093]

[0094] Take by weighing 6.38g of blood-activating and pain-relieving extract prepared in Example 1, 1.28g of IPM, 15.29g of Tween 80, 5.08g of absolute ethanol, and weigh menthol, borneol, camphor, and salicylic acid according to the prescription of Example 1 Methyl ester was stirred at 20-35°C for 40 minutes at a stirring speed of 300-500 rpm. After the drug was completely dissolved, an appropriate amount of water was slowly added and stirred for 20 minutes to obtain 28.03 g of blood-activating and pain-relieving microemulsion.

[0095] Weigh 4.00g of sodium polyacrylate NP-700, 1.5g of cross-linked polyvinylpyrrolidone, 0.10g of aluminum hydroxide, and 0.05g of EDTA-2Na, add 20.00g of glycerin and stir evenly to prepare Phase A. Weigh Povidone K-30 and add appropriate amount of distilled water to fully swell, add 0.40g of citric acid and stir evenly to obtain phase B, add phase B to phase A and then add...

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Abstract

The invention relates to a Chinese herbal compound microemulsion gel emplastrum, and its preparation method and application. In particular, the invention relates to a microemulsion gel emplastrum composition. The microemulsion gel emplastrum composition comprises methyl salicylate, menthol, camphor, borneol, traditional Chinese medicine extract containing active ingredients such as paeonol, eugenol and piperine, a microemulsion matrix, a hydrophilic polymer framework material, a binder, a cross-linking agent, a cross-linking regulator, etc., wherein the active ingredients are entrapped in the microemulsion. The invention further relates to a preparation method for the microemulsion gel emplastrum composition and application of the microemulsion gel emplastrum composition to blood circulation invigoration and pain relieving. The microemulsion gel emplastrum composition in the invention not only ensures high-degree integration of drugs and the matrix, and also has the characteristics of low irritation to skin, little anaphylaxis, good transdermal absorption performance, simple preparation process, etc.

Description

technical field [0001] The invention provides a novel microemulsion gel plaster, its preparation method and its application in medicine. Background technique [0002] The prescription of Huoxue Zhitong Ointment comes from the "Baozhen Ointment" in the seven years of Emperor Kangxi of the Qing Dynasty. It was exclusively developed and produced by Anhui Ankeyu Liangqing Pharmaceutical Co., Ltd. in 1961. It was changed to an adhesive plaster dosage form in 1965 and included in the "Chinese Pharmacopoeia" in 2010. One part has the effects of promoting blood circulation and relieving pain, relaxing tendons and dredging collaterals, and is used for pain in muscles and bones. Muscle paralysis, phlegm nuclei flow, joint pain. Huoxue Zhitong Ointment is applied to local pain in clinical use, and exerts its therapeutic effect through transdermal absorption. Due to its definite curative effect, it has been widely recognized by patients since it was put on the market, with an annual o...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/06A61K9/107A61K47/42A61K47/32A61P29/00A61P19/02A61K31/618A61K31/125A61K31/045
CPCA61K9/0014A61K9/1075A61K31/045A61K31/125A61K31/618A61K36/232A61K36/236A61K36/268A61K36/27A61K36/284A61K36/324A61K36/328A61K36/538A61K36/54A61K36/575A61K36/61A61K36/65A61K36/67A61K36/708A61K36/71A61K36/752A61K36/81A61K36/84A61K36/8884A61K36/8888A61K36/906A61K36/9068A61K47/32A61K47/42A61K2300/00
Inventor 刘淑芝姚瑶刘道芳易红梁日欣何爱萍王岚冯伟红杜茂波刘海兵殷小杰柏金金徐莉莉
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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