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Surface degraded injectable bone filling material and preparation method thereof

A filling material and powder technology, which is used in the fields of medicine and health, medical equipment, and medical materials, can solve the problems of lack of osseointegration, poor bonding strength, material loosening, etc., achieve excellent material/bone interface bonding strength, and improve the success rate. , the effect of preventing instability

Inactive Publication Date: 2017-12-01
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing clinically used PMMA bone filling materials lack effective osseointegration performance, so the bonding strength between its smooth surface and surrounding bone tissue is poor, resulting in later loosening of the material, which ultimately leads to implant failure

Method used

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  • Surface degraded injectable bone filling material and preparation method thereof
  • Surface degraded injectable bone filling material and preparation method thereof
  • Surface degraded injectable bone filling material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Mix PMMA powder, benzoyl peroxide, and zirconium dioxide at a mass ratio of 60:2:38, and then add Mg-Cu alloy (1.5wt.% Cu), whose mass percentage accounts for 20% of the total powder , mix evenly. MMA monomer and N,N-dimethyl polymerized toluidine were mixed at a mass ratio of 99:1, and then hydroquinone was added to make the concentration 5 ppm. The above solid powder and liquid were placed at 4°C for 1 hour, and then mixed at 23°C with a mass volume ratio of 3g:1ml to prepare a surface-degraded injectable bone filling material, which was recorded as 20%-Mg. The particle size of the PMMA powder is 50-70 μm, the particle size of the zirconia powder is 5-20 μm, and the particle size of the Mg-Cu alloy powder is 80-150 μm. The above materials are referred to as 20%-Mg for short,

[0032] Under the same preparation conditions, the Mg-Cu alloy mass percentage accounts for 2% of the total powder (denoted as 2%-Mg), a non-degradable injectable bone filling material that doe...

Embodiment 2

[0037] Mix PMMA powder, benzoyl peroxide, and barium sulfate uniformly at a mass ratio of 70:2:28, then add Zn-Ag alloy (5wt.% Ag), whose mass percentage accounts for 25% of the total powder, and then Mix well. Mix MMA monomer and N,N-dimethyl polymerized toluidine at a mass ratio of 98.5:1.5, then add hydroquinone at a concentration of 8ppm. The above solid powder and liquid were placed at 10°C for 2 hours, and then mixed at 23°C at a mass volume ratio of 2.5g: 1ml to prepare an injectable bone filling material. The PMMA powder particle size is 50-70 μm, the barium sulfate powder particle size is 1-2 μm, and the Zn-Ag alloy powder particle size is 300-400 μm. The other preparation conditions are the same, and the PMMA-based material without Zn-Ag alloy powder is used as the control group.

[0038] The degradation performance of the material was tested by in vitro immersion experiment, using simulated body fluid as the immersion liquid, and the immersion ratio was 1.25cm 2 ...

Embodiment 3

[0042] Mix PMMA powder, benzoyl peroxide, and zirconia at a mass ratio of 65:2:33, and then mix pure zinc (Zn>99.5wt.%), Zn-Cu, Zn-Ag, and Zn-Mg Add, the alloy composition and alloy mass percentage are shown in Table 1, and then uniformly mixed. Mix MMA monomer and N,N-dimethyl polymerized toluidine at a mass ratio of 99:1, and then add hydroquinone at a concentration of 6 ppm. The above solid powder and liquid were placed at 20° C. for 12 hours, and then mixed at 23° C. at a mass volume ratio of 2 g: 1 ml to prepare a bone filling material. Among them, the particle size of PMMA powder is 50-70 μm, the particle size of zirconia powder is 10-20 μm, and the particle size of metal and alloy powder is 100-200 μm. The other preparation conditions were the same, but the bone filling material without alloy powder was used as the control group.

[0043] The degradation performance of the material was tested by in vitro immersion experiment, and the sample size was 10mm in diameter a...

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Abstract

The invention discloses a surface degraded injectable bone filling material and a preparation method thereof. By taking polymethyl methacrylate as a base material, a degradable metal and / or alloy particles are added, the material has good injectability and curing property by solid phase and liquid phase component design, and the material is implanted into a body by injection and can be cured in the body. The degradable metal and / or alloy particles on the surface of the material are reacted with body fluid to be degraded to form holes in the surface, and grow into the surface holes through bones to form mechanical engagement of bone tissues and the material so as to enhance the material / bone tissue interfacial strength. The material disclosed by the invention can improve the interfacial bonding strength of a polymethyl methacrylate material system and bone tissues greatly, and meanwhile has good bio-safety, injectability, curing property and excellent mechanical strength, and can be used in the fields of bone defect filling, arthroplasty, femoral head necrosis treatment and spinal operation and the like. The preparation method disclosed by the invention is simple in process, low in demand on equipment and good in repeatability.

Description

technical field [0001] The invention relates to a bone filling material and a preparation method thereof, in particular to a surface-degradable injectable bone filling material and a preparation method thereof. The invention relates to the fields of medical materials, medical equipment, medicine and sanitation, and the like. Background technique [0002] Injectable bone filling materials have important application value in orthopedic surgery, especially minimally invasive surgery. At present, injectable bone filling materials have been used in orthopedic surgery fields such as filling of bone defects, joint prosthesis fixation, and percutaneous vertebroplasty. Polymethyl methacrylate (PMMA) system injectable bone filling material is currently the most widely used injectable bone filling material due to its excellent operability and mechanical properties, even in the current treatment of percutaneous vertebroplasty. The only clinically used injectable bone filling material....

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/04A61L27/16A61L27/50A61L27/56A61L27/58
CPCA61L27/025A61L27/047A61L27/16A61L27/50A61L27/56A61L27/58A61L2400/06A61L2430/02C08L33/12
Inventor 林潇杨磊杨惠林
Owner SUZHOU UNIV