A phosphorus-containing fluorine-containing polyarylether/nano-hydroxyapatite composite material and its preparation method and application in dental implants

A technology of nano-hydroxyapatite and composite materials, which is applied in prosthetics, medical science, tissue regeneration, etc. It can solve the problems of new phosphorus-containing and fluorine-containing polyarylethers without patent reports, and achieve excellent biological properties and high mechanical properties. performance, excellent bioactivity and biocompatibility

Active Publication Date: 2020-06-16
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the reported polyarylether / nano-hydroxyapatite composite materials are all commercial polyarylethers, such as polyether ether ketone, polyether sulfone, etc., and there is no patent report on a new type of phosphorus-containing fluorine-containing polystyrene prepared in the laboratory. Aryl ether

Method used

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  • A phosphorus-containing fluorine-containing polyarylether/nano-hydroxyapatite composite material and its preparation method and application in dental implants
  • A phosphorus-containing fluorine-containing polyarylether/nano-hydroxyapatite composite material and its preparation method and application in dental implants
  • A phosphorus-containing fluorine-containing polyarylether/nano-hydroxyapatite composite material and its preparation method and application in dental implants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Preparation of anhydride-containing bisphenol monomer

[0027] Add 20g of phenolphthalein into a three-necked flask in an ice-acetone bath, cool to about 0°C, then slowly add 65mL of concentrated sulfuric acid that has been cooled to 0°C, and stir rapidly to make the rearrangement reaction occur; after reacting for 15 minutes, quickly filter and dry to obtain Green solid; add the reaction product and 6.0g maleic anhydride to a three-necked flask in turn, and 125mL glacial acetic acid as solvent for the next reaction; stir rapidly until all the solids are dissolved and a Diels Alder addition reaction occurs, and the color of the solution changes from reddish brown to yellow; Under the catalysis of concentrated sulfuric acid, the reaction product was rearranged, and the reaction was continued for 4 hours to complete the rearrangement reaction; filtered and dried to obtain yellow anhydride bisphenol with a yield of 40%.

Embodiment 2

[0028] Embodiment 2: Preparation of bisphenol monomer containing phosphonic acid group

[0029] Add 3.82g of anhydride-containing bisphenol and 2.08g of p-aminophenylphosphine into a three-necked flask in turn, and then add 36mL of NMP as a solvent; blow nitrogen, stir, and slowly heat to 200°C, the color of the solution changes from yellow to reddish brown, and the reaction process changes from efficient to Followed by liquid chromatography, the reaction was refluxed for 4 hours; a large amount of NMP was distilled off under reduced pressure, and vacuum-dried to obtain phosphonic acid-containing bisphenol with a yield of 80%.

Embodiment 3

[0030] Example 3: Preparation of phosphorus-containing fluorine-containing polyarylether

[0031] Add 1.8274g polyarylether containing phosphonic acid groups, 0.2017g bisphenol AF, 0.2514g difluorotriphenylphosphine, and 0.8136g difluorosulfone into a three-necked flask in turn, then add 2.50g anhydrous potassium carbonate, 20mLDMAc, and 20mL toluene; Nitrogen, raise the temperature to 145°C, make toluene and water azeotrope, remove the water in the system, and control the anhydrous and oxygen-free environment; raise the temperature to 165°C, continue to react for 8 hours until the viscosity of the polymer becomes larger; precipitate with methanol, filter out Solid; redissolve the solid in chloroform to remove inorganic salts, and filter to obtain a pure solution; volatilize and vacuum dry to obtain a polymer whose structural formula is as follows:

[0032]

[0033] Where m+n=x+y, m / n=0~1, x / y=0~1.

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Abstract

The invention discloses a phosphorous-containing and fluorine-containing polyarylether / nanometer hydroxyapatite composite material, and a preparation method and an application thereof in a dental implant. According to the invention, a novel phosphorous-containing and fluorine-containing polyarylether / nanometer hydroxyapatite composite material with different nanometer hydroxyapatites is synthesized through a solution blending method; the phosphorous-containing and fluorine-containing polyarylether / nanometer hydroxyapatite composite material with a best proportion is optimized; and the phosphorous-containing and fluorine-containing polyarylether / nanometer hydroxyapatite composite material has mechanical properties matching with the mechanical properties of human dentale, and has excellent biological activity and biological compatibility. The phosphorous-containing and fluorine-containing polyarylether / nanometer hydroxyapatite composite material provided by the invention contains element phosphorus and element fluorine required by human teeth, is endowed with high mechanical properties like elasticity modulus matching with the human dentale, has excellent biological properties, antibacterial characteristics, etc., thereby obtaining important application values in dental implant materials.

Description

technical field [0001] The invention belongs to the field of polyarylether polymer synthesis, modification and composite material preparation, and in particular relates to a novel phosphorus-containing and fluorine-containing polyarylether / nano-hydroxyapatite composite material and its preparation method and its application in dental implants. application. Background technique [0002] Due to traffic accidents, sports trauma, population aging and chronic dental periodontal disease, as well as the increasing demand for functional restoration and beauty, the number of patients who require implants to restore missing teeth is increasing rapidly worldwide. Demand continues to climb. Dental implants can be used to replace various types of missing dentition, known as the third tooth in humans. However, the functional environment of dental implants is relatively complex. The root of the dental implant needs to be implanted in the alveolar bone and form a firm biological fixation;...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G65/40A61L27/18A61L27/12A61L27/54
CPCA61L27/12A61L27/18A61L27/54A61L2300/216A61L2300/404A61L2430/12C08G65/4006C08G65/4056C08G65/4068C08L71/00
Inventor 王拴紧唐为明孟跃中韩东梅肖敏
Owner SUN YAT SEN UNIV
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