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Device and process for producing acetaminophen

A technology of acetaminophen and bulk packing, applied in the field of chemical engineering, can solve the problems of many by-products, product oxidation, long reaction time, etc., and achieve the effect of improving reaction efficiency and reducing by-products

Pending Publication Date: 2018-03-13
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the above problems, the present invention provides a paracetamol production process and device to solve the problem that the water in the reaction system cannot be removed in time, the reaction time is too long, the product is oxidized, and there are many by-products, which affect the quality and stability of the product. , high energy consumption, high cost and other issues

Method used

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  • Device and process for producing acetaminophen

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Experimental program
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Effect test

Embodiment 1

[0038] Such as figure 1 As shown, a certain enterprise produces a reactive distillation device for acetaminophen, including a split reaction section R101 and a rectification section T101, as well as a condenser E102 and a heat exchanger E101,

[0039] The reaction section R101 is hermetically connected below the rectification section T101,

[0040] Trays are arranged in the rectification section T101, and random packing is arranged below the trays or rectification packings, and a production port and a return port are provided at the top of the rectification section T101, and the production port passes through the The condenser E102 is respectively connected to the return port and the condensation outlet,

[0041] The reaction section R101 is an intensified reactor, the reaction section R101 is provided with a raw material inlet, a circulation outlet and a circulation inlet, the circulation outlet is connected to the inlet of the circulation pump, and the outlet of the circula...

Embodiment 2

[0053]This embodiment 2 adopts the same reactive distillation device as that of embodiment 1. The only difference is that the rectification section is filled with condensate packing; when calculating the distance between the reaction section and the rectification section, the passage time is 0.5 seconds; the diameter of the bottom ceramic ball of the random packing is 15 mm, and The diameter of the layer of ceramic balls is 7 mm, and the diameter of the uppermost layer of ceramic balls is 3 mm; the distance between the bulk packing and the condensed packing is 20 cm.

[0054] During production, the reaction materials p-aminophenol and acetic acid are heated, stirred, dissolved and mixed in the stirring mixing tank V101, and then enter the micro-interface strengthening reactor R101 through the pipeline for reaction, and the reaction materials are circulated through the circulation inlet under the action of the circulation pump , the material heated by the heat exchanger E101 is...

Embodiment 3

[0056] This embodiment 3 adopts the same reactive distillation device as that of embodiment 1. The only difference is that when calculating the distance between the reaction section and the rectification section, the passage time is 0.8 seconds; the diameter of the bottom layer of ceramic balls of random packing is 20 mm, and the diameter of the middle layer of ceramic balls is 8 mm. The diameter of the uppermost layer of ceramic balls is 4 mm; the distance between bulk packing and condensed packing is 30 cm.

[0057] During production, the reaction materials p-aminophenol and acetic acid are heated, stirred, dissolved and mixed in the stirring mixing tank V101, and then enter the micro-interface strengthening reactor R101 through the pipeline for reaction, and the reaction materials are circulated through the circulation inlet under the action of the circulation pump , the material heated by the heat exchanger E101 is vaporized and returned to the reactive distillation device...

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Abstract

The invention discloses a device and a process for producing acetaminophen. The device comprises a split-type reaction section and a rectifying section, wherein the reaction section is connected belowthe rectifying section in a sealed manner, the rectifying section is internally provided with a tower plate or filled with rectifying packing, and random packing is arranged below the rectifying section; the top of the rectifying section is provided with a collecting outlet and a reflux inlet, the collecting outlet is respectively connected with the reflux inlet and a condensing outlet through acondenser, the reaction section is a reinforced reactor, and is provided with a raw material inlet, a circulating outlet and a circulating inlet, the circulating outlet is connected with an inlet of acirculating pump, an outlet of the circulating pump is respectively connected with the circulating inlet, a heat exchanger and a product outlet, and an outlet of the heat exchanger is communicated above an inner liquid surface of the device. The device can be used for distilling moisture timely and guaranteeing reactant concentration, the reaction rate is high, the by-products are few, the energyconsumption is relatively low, the device has a compact structure, the site and space are saved, the reaction heat can be used as all or part of a heat source of the rectifying tower, the energy is saved, and the cost is reduced.

Description

technical field [0001] The invention belongs to the field of chemical engineering, and relates to a production device and process for the acylation reaction of p-aminophenol and acetic acid as raw materials, specifically a new production process capable of continuous reaction and separation by strengthening the coupling of a reactor and a rectification tower scheme. technical background [0002] Acetaminophen, usually a white crystalline powder, is a widely used compound used to prepare the drug paracetamol, which has antipyretic and analgesic properties and is used for cold fever, joint pain, neuralgia, migraine, cancer Pain and postoperative pain relief. The production process of acetaminophen is to carry out acylation reaction with p-aminophenol and acetic acid as raw materials, and its chemical reaction formula is: [0003] . [0004] In this acylation reaction, acetic acid is both a reactant and a solvent at the same time. As can be seen from the reaction equation,...

Claims

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Application Information

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IPC IPC(8): B01J19/00B01D3/00B01D3/32C07C231/02C07C231/24C07C233/25
CPCB01D3/007B01D3/009B01D3/32B01J19/0053B01J19/0093C07C231/02C07C231/24C07C233/25Y02P20/10Y02P20/141
Inventor 周政张志炳王宝荣杨高东罗宋王广辉杜惠媛
Owner NANJING UNIV
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