Multiple-trace element medicinal composition for injection, and use thereof

Abstract

The invention provides an application of a multiple-trace element medicinal composition for injection in the preparation of multiple-trace element injection medicines for preventing or treating multiple-trace element deficiency in humans and mammals, such as zinc, manganese, copper, selenium, fluorine and iodine deficiency and syndromes thereof. The application makes the corresponding products have good safety, good compliance and new adaptive populations in the clinical process.

Description

technical field [0001] The present invention relates to the technical field of medicine, and specifically provides a pharmaceutical composition for various trace element injections for preventing or treating zinc, manganese, copper, selenium, fluorine, iodine deficiency and syndromes thereof, as well as its preparation and application. Background technique [0002] Zinc is an indispensable trace element in organisms, participates in the synthesis of many enzymes in the body, and has important physiological regulation functions. In tissue respiration, zinc plays an important role in protein synthesis, erythrocyte membrane and hematopoiesis. Zinc can combine with mercaptans, block mercaptans and iron, inhibit the catalytic oxidation reaction of iron and form free radicals, zinc can also inhibit fat peroxidation, stabilize cell membranes and make them more resistant to free radical attacks Therefore, zinc is of great significance not only to cell growth but also to cell protec...

AI Technical Summary

Problems solved by technology

4. Lead to the reduction of insulin synthesis and secretion, affecting glucose metabolism

The physiological pH of the human body generally reaches about 7.4. The pH value in the preparation in the prior art is at a very low level. A certain degree of potential safety hazards and some adverse reactions, including vascular irritation or phlebitis or clinical accidents, etc., may lead to a decrease in the efficacy of the drug

[0012] The multiple trace element injection (I) of the prior art (Ministry of Health drug standard (two) volume five) also exists in some cases and is not suitable for patients with hyperchloremia, acidosis and renal insufficiency, etc. Especially in the case of unknown or difficult to know in advance may bring adverse consequences; 【References: Literature 1, Li Zhaoquan, clinical analysis of 12 cases of intracranial hematoma complicated with hypernatremia, Journal of Practical Neurological Diseases, 2005 Year 05, p.44-45; Literature 2, Zhang Xuejun, Chen Zhiqin, Li Hua, Clinical research on hypernatremia and hyperchloremia after cerebral hemorrhage, Journal of Stroke and Neurological Diseases, 2007, Vol. 24, No. 5, p. 609-611; Literature 3, Ji Haiming, Diagnosis and Treatment of 11 Cases of Severe Craniocerebral Injury Complicated with Hyperglycemia, Hypernatremia, and Hyperchloremia, Jiangsu Journal of Clinical Medicine, Volume 2, Issue 6, 1998, p.505, 507; Literature 4 , Yin Peida, The Pathogenesis of Distal Renal Tubular Acidosis, Foreign Medicine (Internal Medicine Volume), No. 12, 1982; Literature 5, Zhou Lei, et al. Analysis of Misdiagnosis and Nursing Care of 12 Patients with Renal Tubular Acidosis, China Practical Journal of Nursing, Issue 17, 2005;]