Multiple-trace element medicinal composition for injection, and use thereof

A technology of trace elements and compositions, applied in the field of medicine, can solve problems affecting sugar metabolism, discomfort, adverse consequences, etc.

Pending Publication Date: 2018-03-30
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4. Lead to the reduction of insulin synthesis and secretion, affecting glucose metabolism
The physiological pH of the human body generally reaches about 7.4. The pH value in the preparation in the prior art is at a very low level. A certain degree of potential safety hazards and some adverse reactions, including vascular irritation or phlebitis or clinical accidents, etc., may lead to a decrease in the efficacy of the drug
[0012] The multiple trace element injection (I) of the prior art (Ministry of Health drug standard (two) volume five) also exists in some cases and is not suitable for patients with hyperchloremia, acidosis and renal insufficiency, etc. Especially in the case of unknown or difficult to know in advance may bring adverse consequences; 【References: Literature 1, Li Zhaoquan, clinical analysis of 12 cases of intracranial hemato

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Embodiment 1 Preparation of small water injection preparations of various trace element pharmaceutical compositions

[0084] Prescription: Zinc Gluconate Hydrate (C 12 h 22 o 14 Zn) 4547.1mg (calculated as zinc gluconate anhydrate)

[0085] Ferric chloride hexahydrate (FeCl 3 ·6H 2 O) 0.54g

[0086] Sodium molybdate dihydrate (Na 2 MoO 4 2H 2 O) 4.85mg

[0087] Chromium chloride hexahydrate (CrCl3 6H2O) 5.33mg

[0088] Copper chloride dihydrate (CuCl 2 2H 2 O) 340mg

[0089] Manganese chloride 4 hydrate (MnCl 2 4H 2 O) 99mg

[0090] Sodium Fluoride (NaF) 210mg

[0091] Sodium selenite pentahydrate (Na 2 SeO 3 ·5H 2 O) 10.5mg

[0092] Potassium iodide (KI) 16.6mg

[0093] Sorbitol (C 6 h 14 o 6 ) 300g

[0094] Sodium Gluconate 5g

[0095] Appropriate amount of 2M gluconic acid solution and 2M sodium lactate solution

[0096] Appropriate amount of water for injection

[0097] Add water for injection to the full volume of 1000ml

[0098] Prepar...

Embodiment 2

[0100] Example 2 Preparation of small water injection preparations of various trace element pharmaceutical compositions

[0101] Prescription: Zinc gluconate trihydrate 4547.1mg (weight based on zinc gluconate anhydrate), ferric chloride hexahydrate 0.54g, sodium molybdate dihydrate 4.85mg, chromium chloride hexahydrate 5.33mg, chlorine Copper chloride dihydrate 340mg, manganese chloride quaternary hydrate 99mg, sodium fluoride 210mg, sodium selenite pentahydrate 10.5mg, potassium iodide 16.6mg, taurine 10g, sorbitol 300g, sodium gluconate 8g, 2M glucose Appropriate amount of acid solution and 2M sodium lactate solution, appropriate amount of water for injection, add water for injection to the full amount of 1000ml

[0102] Preparation process: Weigh or prepare raw and auxiliary materials according to the prescription quantity, step 1, stir and dissolve the prescription quantity of taurine, sodium gluconate, and sorbitol with an appropriate amount of fresh water for injection,...

Embodiment 3

[0103] Example 3 Preparation of Small Water Injection Preparation of Various Trace Element Pharmaceutical Compositions

[0104] Prescription: Zinc gluconate trihydrate 4547.1mg (weight based on zinc gluconate anhydrate), ferric chloride hexahydrate 0.54g, sodium molybdate dihydrate 4.85mg, chromium chloride hexahydrate 5.33mg, chlorine Copper chloride dihydrate 340mg, manganese chloride quaternary hydrate 99mg, sodium fluoride 210mg, sodium selenite pentahydrate 10.5mg, potassium iodide 16.6mg, taurine 30g, sorbitol 20g, glycine 20g, gluconic acid 20g, Sodium gluconate 10g, appropriate amount of 2M gluconic acid solution and 2M sodium lactate solution, appropriate amount of 5M sodium hydroxide solution, appropriate amount of water for injection, add water for injection to the full amount of 1000ml

[0105] Preparation process: Weigh or prepare raw and auxiliary materials according to the prescription quantity. Step 1. Stir and dissolve the prescription quantity of taurine, sor...

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PUM

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Abstract

The invention provides an application of a multiple-trace element medicinal composition for injection in the preparation of multiple-trace element injection medicines for preventing or treating multiple-trace element deficiency in humans and mammals, such as zinc, manganese, copper, selenium, fluorine and iodine deficiency and syndromes thereof. The application makes the corresponding products have good safety, good compliance and new adaptive populations in the clinical process.

Description

technical field [0001] The present invention relates to the technical field of medicine, and specifically provides a pharmaceutical composition for various trace element injections for preventing or treating zinc, manganese, copper, selenium, fluorine, iodine deficiency and syndromes thereof, as well as its preparation and application. Background technique [0002] Zinc is an indispensable trace element in organisms, participates in the synthesis of many enzymes in the body, and has important physiological regulation functions. In tissue respiration, zinc plays an important role in protein synthesis, erythrocyte membrane and hematopoiesis. Zinc can combine with mercaptans, block mercaptans and iron, inhibit the catalytic oxidation reaction of iron and form free radicals, zinc can also inhibit fat peroxidation, stabilize cell membranes and make them more resistant to free radical attacks Therefore, zinc is of great significance not only to cell growth but also to cell protec...

Claims

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Application Information

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IPC IPC(8): A61K33/34A61K9/08A61P3/02A61K33/32A61K33/30A61K33/18A61K33/16A61K33/04
CPCA61K9/0019A61K9/08A61K33/04A61K33/16A61K33/18A61K33/30A61K33/32A61K33/34A61K2300/00
Inventor 刘力
Owner 刘力
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