Multiple-trace element medicinal composition for injection, and use thereof

Abstract

The invention provides an application of a multiple-trace element medicinal composition for injection in the preparation of multiple-trace element injection medicines for preventing or treating multiple-trace element deficiency in humans and mammals, such as zinc, manganese, copper, selenium, fluorine and iodine deficiency and syndromes thereof. The application makes the corresponding products have good safety, good compliance and new adaptive populations in the clinical process.

Description

technical field [0001] The present invention relates to the technical field of medicine, and specifically provides a pharmaceutical composition for various trace element injections for preventing or treating zinc, manganese, copper, selenium, fluorine, iodine deficiency and syndromes thereof, as well as its preparation and application. Background technique [0002] Zinc is an indispensable trace element in organisms, participates in the synthesis of many enzymes in the body, and has important physiological regulation functions. In tissue respiration, zinc plays an important role in protein synthesis, erythrocyte membrane and hematopoiesis. Zinc can combine with mercaptans, block mercaptans and iron, inhibit the catalytic oxidation reaction of iron and form free radicals, zinc can also inhibit fat peroxidation, stabilize cell membranes and make them more resistant to free radical attacks Therefore, zinc is of great significance not only to cell growth but also to cell protec...

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Problems solved by technology

4. Lead to the reduction of insulin synthesis and secretion, affecting glucose metabolism

The physiological pH of the human body generally reaches about 7.4. The pH value in the preparations in the prior art is at a very low level, and its pH value is between 1.8 and 2.2. Strong acidity is brought about by different intravenous drug preparations and clinical intravenous infusions. A certain degree of potential safety hazards and some adverse reactions, including vascular irritation or phlebitis or clinical accidents, etc., may lead to a decrease in the efficacy of the drug

[0009] The various trace element injections (I) of the prior art are also not suitable for patients with hyperchloremia, acidosis and renal insufficiency in some cases, especially in the case of unknown or difficult to know in advance Taking it may bring adverse consequences; excessive intake of chloride ions is not good for children with autism; [References on hyperchloremia or acidosis: Literature 1, Li Zhaoquan, Hypernatremia after intracranial hematoma surgery 12 Clinical Analysis of Cases, Journal of Practical Neurological Diseases, Issue 05, 2005, p.44-45; Literature 2, Zhang Xuejun, Chen Zhiqin, Li Hua, Clinical Research on Hypernatremia and Hyperchloremia after Cerebral Hemorrhage, Journal of Stroke and Neurological Diseases, 2007 Volume 24, Issue 5, p.609-611; Literature 3, Ji Haiming, Experience in the Diagnosis and Treatment of 11 Cases of Severe Craniocerebral Injury Complicated with Hyperglycemia, Hypernatremia, and Hyperchloremia, Jiangsu Journal of Clinical Medicine, Volume 2, No. 6, 1998 Issues, p.505, 507; Document 4, Yin Peida, Pathogenesis of Distal Renal Tubular Acidosis, Foreign Medicine (Internal Science Volume), Issue 12, 1982; Document 5, Zhou Hui, et al., Children's third ventricle Prevention and treatment strategies for postoperative complications of pharyngioma, Journal of Clinical Neurosurgery, Issue 05, 2011; Literature 6, Zhou Lei, et al., Analysis of Misdiagnosis Causes and Nursing Care of 12 Patients with Renal Tubular Acidosis, Chinese Journal of Practical Nursing, 2005 17 Expect;】

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