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A kind of preparation method of medical polyester polymer superfine powder

An ultra-fine powder and polymer technology, which is used in pharmaceutical formulations, pharmaceutical science, drug delivery, etc., can solve the problems of complicated impurity removal, wear and tear of crushing equipment, and high amount of impurities, and achieves safe operation, easy operation, and uniform powder. Effect

Active Publication Date: 2020-07-10
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The traditional preparation methods of medical polyester polymer ultrafine powder include low-temperature grinding, solvent emulsification, spray drying and other processes, but conventional low-temperature grinding requires a large amount of liquid nitrogen, dry ice, etc., and the average particle size of the final pulverization is above 100 μm, and The amount of impurities introduced is large, which will cause serious wear and tear on the crushing equipment; solvent emulsification usually adds solvents and surfactants, and the subsequent impurity removal process is complicated and the yield is low; the molecular weight of medical polyester polymer polymer materials is large, so the spray A large amount of organic solvent is required in the drying process, and the process of chemical residue treatment in the later stage is cumbersome, and the effect is not good, and a lot of resources are wasted

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  • A kind of preparation method of medical polyester polymer superfine powder
  • A kind of preparation method of medical polyester polymer superfine powder

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preparation example Construction

[0032] A preparation method of medical polyester polymer superfine powder, comprising the following steps:

[0033] ① Freeze the medical polyester material at -70°C~-200°C for 1~2 hours, grind and pulverize it with a pulverizer, and sieve to obtain medical polyester particles with an average particle size of 100~200μm; the medical polyester material It is poly-L-lactide, poly-D, L-lactide, polyglycolide, polycaprolactone, polytrimethylene carbonate, polydioxanone or a combination of two or more of the foregoing A copolymer obtained by copolymerizing polymer monomers;

[0034] ② adding the medical polyester granules and inorganic salt obtained in step ① into the solvent, and mixing evenly to obtain a block stent material;

[0035] The inorganic salt is sodium chloride, calcium chloride, magnesium chloride, potassium chloride, sodium sulfate or potassium sulfate; the average particle diameter of the inorganic salt is 1 ~ 150 μm, and the solvent is water and / or ethanol; wherein ...

Embodiment 1

[0055] A preparation method of medical polyester polymer superfine powder, comprising the following steps:

[0056] ① Freeze the medical polyester material in liquid nitrogen at -70°C for 2 hours, grind and pulverize it with a pulverizer, and sieve to obtain medical polyester particles with an average particle size of 100 μm; the medical polyester material is poly-L - lactide;

[0057] ②Add 30g of medical polyester granules obtained in step ① and 100g of inorganic salt into 1L of solvent, and mix evenly to obtain a block-shaped scaffold material;

[0058] The inorganic salt is sodium chloride; the average particle diameter of the inorganic salt is 1 μm, and the solvent is water;

[0059] ③ Place the block scaffold material obtained in step ② in a dialysis bag with a molecular weight cut-off of 3000, and dialyze in a phosphate buffer solution with a pH of 7.4 for 15 hours to obtain a scaffold material with a porous structure;

[0060] ④ Freeze the scaffold material with porou...

Embodiment 2

[0062] A preparation method of medical polyester polymer superfine powder, comprising the following steps:

[0063] ① Freeze the medical polyester material in a liquid nitrogen environment at -200°C for 2 hours, grind and pulverize it with a pulverizer, and sieve to obtain medical polyester particles with an average particle size of 200 μm; the medical polyester material is poly-D , L-lactide;

[0064] 2. Add 25g of the medical polyester particles obtained in step 1. and 200g of inorganic salt into 100ml of solvent, and mix uniformly to obtain a massive scaffold material; the inorganic salt is calcium chloride; the average particle diameter of the inorganic salt is 150 μm, and the The solvent is ethanol;

[0065] ③ Place the block scaffold material obtained in step ② in a dialysis bag with a molecular weight cut-off of 4000, and dialyze in a phosphate buffer solution with a pH of 7.4 for 30 hours to obtain a scaffold material with a porous structure;

[0066] ④ Freeze the sc...

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Abstract

The invention discloses a preparation method of superfine powder of medical polyester polymer, which comprises the steps of crushing the medical polyester material into large particles after cryogenic cooling, then adding it to the solvent with inorganic salt, and adding ice particles or the same material if necessary Adhesive to obtain a block scaffold material, then put it into a dialysis bag for dialysis, and then crush it after cryogenic cooling to obtain an ultrafine powder with an average particle diameter of 20-80 μm. The medical polyester polymer obtained by the preparation method of the present invention The average particle size of the ultra-fine powder is 20-80 μm, which can meet the clinical requirements for the particle size of the polymer ultra-fine powder, and will not introduce impurities such as organic solvents and surfactants during the preparation process, which meets the requirements of medical polyester polymers. Requirements for indicators such as heavy metals and residue on ignition; the preparation process does not involve the dissolution of organic solvents, so there will be no problem of solvent residues, and only a small amount of low-temperature substances such as liquid nitrogen and dry ice are needed in the crushing process, which reduces the loss of equipment. , safe operation, energy saving and environmental protection.

Description

technical field [0001] The invention relates to the technical field of polymer processing, in particular to a preparation method of superfine powder of medical polyester polymer. Background technique [0002] Medical polyester polymer polymer materials have broad prospects in the medical field. With the continuous development of cosmetic technology, their applications in cosmetic filling, wrinkle removal, etc. are also increasing. Due to medical polyester polymer polymer materials It has good flexibility and does not expect strict requirements on the amount of impurities introduced during the preparation process, so the preparation of polyester polymer ultrafine powders that meet the requirements has become a worldwide problem. [0003] The traditional preparation methods of medical polyester polymer ultrafine powder include low-temperature grinding, solvent emulsification, spray drying and other processes, but conventional low-temperature grinding requires a large amount of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/50A61L27/18
CPCA61L27/18A61L27/50A61L27/56A61L2400/12C08L67/04
Inventor 王宪朋刘阳马丽霞董浩朱爱臣李俊起吴倩倩王传栋王勤
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES