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Preparation method of starch granule based multi-chamber structure polymer particle

A starch granule and multi-chamber structure technology, applied in the field of materials, can solve the problems of limiting the development and application of multi-chamber structure polymer particles, poor repeatability, and lack of

Active Publication Date: 2018-05-04
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the published literature or patents, the current methods for preparing polymer particles with multi-chamber structure mainly include self-assembly method, electrospray method and microfluidic method, etc. These methods generally have complex preparation methods, high cost, poor reproducibility, and The problems of low yield and poor biocompatibility of the prepared materials, and the lack of simple, cheap and stable preparation technology severely limit the development and application of multi-chamber polymer particles.

Method used

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  • Preparation method of starch granule based multi-chamber structure polymer particle
  • Preparation method of starch granule based multi-chamber structure polymer particle
  • Preparation method of starch granule based multi-chamber structure polymer particle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Stir and mix 5g cornstarch granules and 150g deionized water to obtain a starch emulsion. After 15 minutes of passing through nitrogen, add 20g of methyl methacrylate and stir for 0.5 hours. After adjusting the temperature of the water bath to 30°C, add 0.05g of persulfuric acid ammonium, 0.03g sodium bicarbonate, react at a reaction temperature of 30°C for 12 hours, cool to room temperature after the reaction, and obtain a starch / polymer particle emulsion with a core-shell structure.

[0030] Stir the prepared starch / polymer particle emulsion with a core-shell structure and raise the temperature to 45°C, slowly add 0.5g of styrene-butadiene latex agglomerating agent, stir while adding, and react for 3 hours to obtain multi-particle agglomerated starch / polymer particle emulsion particle emulsion. Get 50ml of multi-particle agglomerated starch / polymer particle emulsion and add it to 500ml of 1% α-amylase solution, heat up to 40°C, stir slowly, and react for 24 hours. Aft...

Embodiment 2

[0032] Stir and mix 3g of tapioca starch granules and 120g of deionized water to obtain a starch emulsion. After passing through nitrogen for 30 minutes, add 10g of lactic acid and stir for 1 hour. After adjusting the temperature of the water bath to 40°C, add 0.05g of azobisisobutyronitrile , react at a reaction temperature of 40° C. for 2 hours, cool to room temperature after the reaction, and obtain a starch / polymer particle emulsion with a core-shell structure.

[0033] Stir the prepared starch / polymer particles with a core-shell structure and raise the temperature to 45°C, slowly add 0.5g carboxylated styrene-butadiene latex agglomeration agent, stir while adding, and react for 1 hour to obtain multi-particle agglomerated starch / polymer particles particle emulsion. Add 70ml of multi-particle agglomerated starch / polymer particle emulsion into 300ml of 1% α-amylase and 5% glucoamylase solution, heat up to 40°C, stir slowly, and react for 10 hours. After the reaction finishe...

Embodiment 3

[0035] Stir and mix 10g of quinoa starch granules with 200g of deionized water to obtain a starch emulsion. After passing through nitrogen for 25 minutes, add 30g of methyl acrylate and stir for 0.5 hours. After adjusting the temperature of the water bath to 40°C, add 0.2g of cumene Hydrogen peroxide and 0.1 g of sodium bisulfite were reacted at a reaction temperature of 40° C. for 6 hours, cooled to room temperature after the reaction, and a starch / polymer particle emulsion with a core-shell structure was obtained.

[0036]Stir the prepared starch / polymer particle emulsion with core-shell structure and heat up to 50°C, slowly add 1.5g of cellulose agglomerating agent, stir while adding, and react for 10 hours to obtain multi-particle agglomerated starch / polymer particle emulsion. Add 20ml of multi-particle agglomerated starch / polymer particle emulsion into 1000ml of 1% α-amylase and 3% degrafting enzyme solution, heat up to 65°C, stir slowly, and react for 10 hours. After the...

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Abstract

The invention discloses a preparation method of a starch granule based multi-chamber structure polymer particle. The method comprises the following steps that a starch granule is taken as a primary particle, and the starch surface polymerization method, the agglomeration reaction method, the amylase catalytic hydrolysis method and the like are combined to prepare the multi-chamber structure polymer particle. The composition and the structure of the multi-chamber structure polymer particle are regulated by changing the varieties of monomers, the use level of reactants and the reaction conditions. The preparation method of the starch granule based multi-chamber structure polymer particle uses the characteristics of low cost and environmental friendliness of the starch, the synthesized polymer particle is not contaminated, the preparation method is simple, the cost is low, and the preparation method can be applied in various fields like bio-pharmaceutical engineering, material science andcatalyst science.

Description

technical field [0001] The invention relates to a preparation method of a starch granule-based multi-chamber structure polymer particle, which belongs to the field of material technology. Background technique [0002] Multi-compartmentalization is ubiquitous in nature, and its important role can be found in microbe structures as large as human physiological structures. Inspired by these phenomena, polymer particles with multi-chamber structure can be used for multi-drug delivery, multi-catalyst synergy, cell biomimetic, etc. The prospect has attracted extensive attention from the scientific community. [0003] At present, polymer particles with a single-chamber hollow structure are mostly studied, and the research on polymer particles with a multi-chamber structure is still in its infancy. The interior of multi-chamber polymer particles usually contains two or more cavities, each cavity is separated by a polymer film, each cavity can independently encapsulate different com...

Claims

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Application Information

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IPC IPC(8): C08J9/26C08F120/14C08G63/08C08G18/64C08F120/18C12P19/14C12P19/22C12P19/16
CPCC12P19/14C12P19/16C12P19/22C08F120/14C08F120/18C08G18/6484C08G63/08C08J9/26C08J2201/0422C08J2333/12C08J2333/10C08J2333/08C08J2367/04C08J2375/04
Inventor 成世杰王硕陈晨
Owner QINGDAO UNIV OF SCI & TECH
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