A kind of preparation method of 1,10-decanediol

Abstract

The present invention relates to a preparation method of 1,10-decanediol. The method is characterized by using 9-decenoic acid ester as a raw material, adopting a two-step epoxidation-transfer hydrogenation reaction to obtain 1,10-decanediol, and the epoxidation step uses a molybdenum catalyst and an organic peroxide, and 9 , The yield of 10-epoxidized methyl decanoate is greater than 95%; the hydrogen donor is used in the transfer hydrogenation reaction to replace hydrogen, and a reducing additive is introduced to reduce the epoxy group and the ester group to a hydroxyl group in one step under normal pressure. The method does not need to use high-pressure hydrogen, which not only reduces the investment of the reaction device, reduces the complexity of the operation, but also increases the safety of the reaction, improves the yield of the target product, and solves the difficulty of product separation and a large number of difficulties in the traditional production technology. To deal with problems such as industrial waste water, the raw material 9-decenoate is cheap and easy to obtain, the preparation process is simple, the equipment requirements are not high, and it is suitable for industrial production.

Description

Technical field[0001]The invention relates to a preparation method of 1,10-decanediol, which belongs to the field of fine organic chemical industry.Background technique[0002]1,10-Decanediol (1,10-Decanediol), also known as 1,10-dihydroxydecane, is an important chemical raw material and pharmaceutical intermediates, mainly used in the manufacture of medicines and materials, such as the production of double Iododecane is used to prepare medicines such as antibacterial and antimycotic drugs (double) clonidine and octenidine, and can also be used to prepare functional materials, adhesives, polymer materials, etc., and has a wide range of uses.[0003]In the traditional process, 1,10-decanediol is firstly prepared from ricinoleic acid through high-temperature cracking to obtain 1,10-sebacic acid, and then obtained through esterification and hydrogenation reactions. Among them, both esterification and hydrogenation reduction are very important. Mature reaction, so castor oil pyrolysis to pr...

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Problems solved by technology

[0006] The traditional manufacturing method has the following problems: long production cycle, poor product quality, toxic phenolic substances, corrosion of equipment, and pollution of the environment

[0009] Hydrogenation reaction is one of the commonly used reaction types in industry, but due to the extremely flammable and explosive risks of hydrogen, hydrogenation reaction is often accompanied by great danger; at the same time, in order to improve selectivity and conversion rate, hydrogenation reaction is generally It is carried out under high pressure, which requires a series of high-pressure-resistant equipment such as high-pressure reactors, which will not only increase equipment investment, but also increase the complexity of operation. High-pressure reactions also have the risk of hydrogen leakage, and the safety hazard is very prominent.

Therefore, although the above method provides a new idea for the synthesis of decanediol, the total yield is too low to have practical application value, and the high-pressure hydrogenation reaction increases equipment investment and safety hazards

[0010] As can be seen from the above, the preparation of decanediol from castor oil has the disadvantages of harsh reaction conditions and prominent waste problems; the two-step method of preparing decanediol with 1,9-decadiene as a raw material has low total product yields and poor equipment Disadvantages such as large investment and high risk of operation

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