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A kind of nattokinase pan-plastic pill and preparation method thereof

A technology of nattokinase and carbohydrates, which is applied in the field of nattokinase pan-plastic pills and its preparation, can solve the problems of low absorption rate and utilization rate, hidden dangers, complicated process, etc. reasonable effect

Active Publication Date: 2021-08-27
HEZE RUIZHI TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In summary, the following problems exist in the production and application of nattokinase products: (1) Using ethanol as a solvent has potential safety hazards, and the unpleasant smell cannot be improved
(2) Existing dosage forms such as tablets, capsules, and granules have complicated processes, low active ingredients of nattokinase, and low absorption and utilization rates. The key is that such dosage forms are not suitable for food
(3) Low encapsulation rate of nattokinase microcapsules
(4) Nattokinase drinks, emulsifiers, etc. have the problem of inactivation of nattokinase in gastric juice

Method used

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  • A kind of nattokinase pan-plastic pill and preparation method thereof
  • A kind of nattokinase pan-plastic pill and preparation method thereof
  • A kind of nattokinase pan-plastic pill and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Effects of Different Sugars in Nattokinase Panplastic Pills on the Activity of Nattokinase in the Stomach

[0032] (1) Sugar pretreatment

[0033] Pour honey, fructose syrup, maltose syrup, pullulan, etc. into a beaker, add purified water, and heat slowly with an electric heating mantle until the temperature reaches 116~119°C. Refining for about 2 hours, reddish-brown luster and large bubbles appear, stop Refining;

[0034] (2) Nattokinase preparation

[0035] According to nattokinase: starch auxiliary material = 1:1 (w / w), mix well to obtain nattokinase diluted medicinal powder with a content of about 20000FU / g;

[0036] (3) Preparation of soft materials

[0037] Put the refined sugar and Sichuan wax (Sichuan wax: honey = 1.5:3.5 (w / w)) into a beaker, melt in a water bath, then add an equal weight of starch auxiliary material, stir quickly and mix well to form a ball; get a soft material.

[0038] (4) Preparation of Panplastic Pills

[0039] Weigh 0.45g...

Embodiment 2

[0045] Example 2 Adding different adjuvants to the effect of nattokinase enzyme inactivation rate in the stomach

[0046] (1) Honey pretreatment

[0047] Pour the honey into a beaker, add purified water, and heat slowly with an electric heating mantle until the temperature reaches 116~119°C. Refining for about 2 hours, reddish-brown luster and large bubbles appear, stop honey refining;

[0048] (2) Nattokinase preparation

[0049] Mix dextrin, starch, and wheat flour with nattokinase at a ratio of 1:1 (w / w) to obtain diluted nattokinase powder with a content of about 20,000 FU / g;

[0050](3) Preparation of soft materials

[0051] Put the refined honey and Chuanwa (Chuanwa: honey = 1.5:3.5 (w / w)) into a beaker, melt in a water bath, then add an equal weight of auxiliary materials (dextrin or starch or wheat flour), and stir quickly Mixed into a mass; to obtain a soft material

[0052] (4) Preparation of Panplastic Pills

[0053] Weigh 0.45g of soft material, pack 0.025g of...

Embodiment 3

[0059] Example 3 Adding different waxes to the effect of nattokinase enzyme activity in the stomach inactivation rate

[0060] (1) Honey pretreatment

[0061] Pour the honey into a beaker, add purified water, and heat slowly with an electric heating mantle until the temperature reaches 116~119°C. Refining for about 2 hours, reddish-brown luster and large bubbles appear, stop honey refining;

[0062] (2) Nattokinase preparation

[0063] According to nattokinase: dextrin auxiliary material = 1:1 (w / w), mix well to obtain nattokinase diluted medicinal powder with a content of about 20000FU / g;

[0064] (3) Preparation of soft materials

[0065] Put beeswax, Sichuan wax or carnauba wax, and refined honey in a weight ratio of 1.5:3.5 into a beaker, melt in a water bath, then add dextrin auxiliary materials of equal weight, stir and mix quickly to form a ball; get soft material.

[0066] (4) Preparation of Panplastic Pills

[0067] Weigh 0.45g of soft material, pack 0.025g of na...

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PUM

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Abstract

The invention belongs to the technical field of food production, in particular to a nattokinase pan-plastic pill and a preparation method thereof. The present invention comprises soft material coating layer and active ball core layer, and nattokinase pan-plastic pill soft material coating layer comprises beeswax, honey, dextrin; Nattokinase active ball core layer comprises dextrin: nattokinase=1: 1. The nattokinase content of the prepared panplastic pills is 500±20FU / pill. The invention provides a method for making nattokinase-coated pan-plastic pills. The specific preparation method includes the following steps: 1) preparation of nattokinase; 2) honey pretreatment; 3) preparation of soft material of pan-plastic pills; 4) packaging Preparation of Yifansu pills. The invention solves the key problem of inactivation of nattokinase in gastric juice, and the auxiliary materials used are materials from the same origin of traditional medicine and food in China. Long-term use is harmless to humans. The method is scientific, the process is reasonable, and it is beneficial to environmental protection. The invention can be widely used in the fields of food, health food, medicine production and the like.

Description

[0001] (1) Technical field [0002] The invention belongs to the technical field of food production, in particular to a nattokinase pan-plastic pill and a preparation method thereof. [0003] (2) Background technology [0004] Thrombotic disease poses a serious threat to human health. Nowadays, various new antithrombotic drugs have emerged one after another, such as streptokinase, urokinase, t-PA, lumbrokinase, staphylokinase, etc. These thrombolytic agents have side effects Too big, high cost, low potency, easy to cause bleeding, can not be administered orally, can only be injected intravenously, expensive, source shortage and other disadvantages. [0005] Nattokinase was first discovered and named by Sumi Yoko and others in Japan. It was originally isolated from natto. It is a secondary metabolite produced by Bacillus subtilis and is a serine protease. Its thrombolytic activity is It is 4 times that of plasmin, and it is a single-chain polypeptide protease linked by 275 amin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/48A61K9/28A61K47/46A61K47/36A61K47/44A61P7/02A23L33/125A23L29/00
CPCA23V2002/00A61K9/2059A61K9/282A61K9/286A61K9/288A61K38/482A23L29/06A23L33/125C12Y304/21062A23V2200/224A23V2200/30
Inventor 周汝德李振森张媛彭继先
Owner HEZE RUIZHI TECH DEV