Modified SEBS material and preparation method and application thereof

A modification and reaction technology, which is applied in the field of modified SEBS materials and its preparation, can solve the problems of easy adsorption of plasma proteins, blood coagulation and thrombus, low immune activity, etc., to improve the ability to resist protein and platelet adhesion, good society Economic benefit, effect of improving blood compatibility

Active Publication Date: 2018-07-06
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the surface energy of SEBS is low. When the material is in contact with blood, the surface of the material is easy to adsorb plasma proteins, which in turn promotes the adhesion and activation of platelets, eventually leading to coagulation and thrombus.
In addition, there are no reactive functional groups on the surface of SEBS, which has certain limitations on its surface modification, and common surface modification methods such as: ultraviolet radiation, ozone irradiation, surface initiation-atom trans...

Method used

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  • Modified SEBS material and preparation method and application thereof
  • Modified SEBS material and preparation method and application thereof
  • Modified SEBS material and preparation method and application thereof

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preparation example Construction

[0042] The invention provides a kind of preparation method of modified SEBS material, comprises the following steps:

[0043] Provide a dopamine-modified SEBS, the SEBS is reacted in a hydrophilic polymer solution to obtain a modified SEBS material;

[0044] The two terminal groups of the hydrophilic polymer are independently selected from mercapto, amino, carboxyl or sulfonic acid groups.

[0045] In the preparation method provided by the present invention, a dopamine-modified SEBS is firstly provided, and the preparation method of the dopamine-modified SEBS has been introduced above, and will not be repeated here.

[0046] After obtaining the dopamine-modified SEBS, the SEBS was reacted in a hydrophilic polymer solution. Wherein, the hydrophilic polymer has been introduced above and will not be repeated here; the content of the hydrophilic polymer in the hydrophilic polymer solution is preferably 0.05-10 mg / ml, specifically 0.05 mg / ml, 0.1mg / ml, 0.5mg / ml, 1mg / ml, 1.5mg / ml,...

Embodiment 1

[0052] Mix Tris and water and adjust the pH with hydrochloric acid to obtain a Tris-HCl solution with a pH of 7.5-9.5; mix dopamine with the above-mentioned Tris-HCl solution to obtain a dopamine / Tris-HCl aqueous solution with a dopamine content of 2 wt%; monomercapto PEG (Number average molecular weight 5k) and the above-mentioned Tris-HCl solution are mixed to obtain a monothiol PEG content of 5 mg / ml monothiol PEG (5k) / Tris-HCl solution; Dimercapto PEG (number average molecular weight 5k) and the above-mentioned Tris-HCl solution Mix to obtain a bis-mercapto PEG (5k) / Tris-HCl solution with a bis-mercapto PEG content of 5 mg / ml.

[0053] SEBS powder (manufacturer Kraton, brand G1652, polystyrene content 29wt%) was formulated into a 15wt% SEBS xylene solution, and the solution was drip-coated on a glass plate and volatilized to obtain an SEBS film. The SEBS membrane was immersed in the above-mentioned dopamine / Tris-HCl aqueous solution, stirred at room temperature for 2 hours...

Embodiment 2

[0070] Mix Tris and water and adjust the pH with hydrochloric acid to obtain a Tris-HCl solution with a pH of 7.5-9.5; mix dopamine with the above-mentioned Tris-HCl solution to obtain a dopamine / Tris-HCl aqueous solution with a dopamine content of 2 wt%; monomercapto PEG (Number average molecular weight 5k) mixed with the above-mentioned Tris-HCl solution to obtain a monothiol PEG (5k) / Tris-HCl solution with a monothiol PEG content of 5mg / ml; The HCl solutions were mixed to obtain a bis-thiol PEG (5k) / Tris-HCl solution with a bis-thiol PEG content of 5 mg / ml.

[0071] SEBS is prepared as a toluene solution of 2wt% SEBS, 10 microliters are dropped on a dissipative quartz crystal microbalance (QCM-D) gold chip, spin-coated with a spin coater at 3000 rpm for 20 seconds, and vacuum-dried overnight at 50° C. Then immersed in dopamine / Tris-HCl aqueous solution, stirred at room temperature for 2 h, rinsed with deionized water three times, washed with ethanol once, and blown dry with...

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Abstract

The invention belongs to the field of high molecular materials and particularly relates to a modified SEBS material and a preparation method and application thereof. The material comprises dopamine-modified SEBS and a hydrophilic polymer of which two end groups are grafted on the surface of the SEBS, wherein the two end groups of the hydrophilic polymer are selected from sulfhydryl group, amino group, carboxyl group or sulfonic group. The material provided by the invention is characterized in that dopamine is taken as a bionic adhesive, and two ends of the hydrophilic polymer are fixed on thesurface of the SEBS to construct a loop conformation of the hydrophilic polymer; and the whole surface grafting process does not use an organic solvent, thereby avoiding the pollution and poison of the organic solvent. By constructing the hydrophilic polymer of the loop conformation on the surface of the SEBS, the capability of the SEBS material for resisting protein and platelet adhesion is further improved in comparison with the mode of constructing a hydrophilic polymer of a brush conformation on the surface of the SEBS, and excellent blood compatibility is shown. The material provided by the invention can generate good social and economic benefits when being applied to the field of biomedical materials.

Description

technical field [0001] The invention belongs to the field of polymer materials, and in particular relates to a modified SEBS material and its preparation method and application. Background technique [0002] With the development of medicine, life science, and material science, biomaterials have good development prospects, such as applications in artificial hearts, artificial blood vessels, blood bags, etc., which are closely related to human health. Polymer materials are widely used in the field of biomaterials due to their unique properties. At present, the most widely used polymer material in the field of biomaterials is polyvinyl chloride (PVC), but because PVC is easy to precipitate harmful plasticizers bis(2-ethyl)hexyl phthalate (DEHP) and Poor radiation resistance, limited sterilization and other shortcomings, a lot of work has been done in the development of medical PVC alternative materials at home and abroad. [0003] Hydrogenated styrene-butadiene block copolyme...

Claims

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Application Information

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IPC IPC(8): C08J7/12C08J5/18C08L53/02A61L31/04A61L31/14A61L27/50A61L27/16
CPCA61L27/16A61L27/50A61L31/048A61L31/14A61L2400/18C08J5/18C08J7/12C08J2353/02
Inventor 姜伟吕建华金晶
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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