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Thermosensitive substance concentration system and method thereof

A concentration system, heat-sensitive technology, applied in chemical instruments and methods, vacuum distillation, membrane, etc., can solve the problem of membrane separation operation efficiency drop

Pending Publication Date: 2018-07-20
上海飞态环保科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Membrane separation operation also has its operating limitations. When the concentration of substances is too high, the efficiency of membrane separation operation will decrease

Method used

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  • Thermosensitive substance concentration system and method thereof
  • Thermosensitive substance concentration system and method thereof
  • Thermosensitive substance concentration system and method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Concentration of clavulanic acid.

[0040] Clavulanic acid is an irreversible competitive β-lactamase inhibitor, which will inactivate the enzyme after being firmly combined with the enzyme, so it has a strong effect, not only on the β-lactamase of Staphylococcus aureus, but also on Gram The β-lactamase of negative bacilli also plays a role. Combined with penicillins and cephalosporins, the antibacterial activity is greatly improved, and the minimum inhibitory concentration (MIC) can be significantly reduced. The drug can increase the efficacy by several to ten times, and restore the sensitivity of drug-resistant strains. The production of clavulanic acid needs to be carried out at 8°C, and the vacuum distillation concentration needs to be carried out at 15°C.

[0041] like figure 1 As shown in the flow chart, in this example, the Puramem Flux type organic solvent-resistant nanofiltration membrane is used for pre-concentration, and then the clavulanic acid is concentr...

Embodiment 2

[0044] In this example, the Puramem Flux type organic solvent-resistant nanofiltration membrane was used for pre-concentration, then the clavulanic acid was concentrated to the target concentration by vacuum distillation, and finally the water content of the concentrate was reduced by freeze-drying and dehydration.

[0045] like figure 2 As shown in the process flow, 8L of clavulanic acid ethyl acetate solution with an initial concentration of 10200ug / mL and a water content of 2% is placed in the primary storage tank 1 of the membrane separation equipment, and the concentrated solution is transported into a The membrane group of the 1.8-inch solvent-resistant nanofiltration membrane is the primary nanofiltration membrane group 3. Adjust the back pressure valve to make the system generate a pressure of 30 bar, and the three-way valve 6 returns the membrane concentrate to the primary storage tank 1 to obtain 6L carat The permeate with a tretinoin concentration of 505ug / mL. Whe...

Embodiment 3

[0047] Penicillin potassium is a β-lactam antibiotic that has a strong antibacterial effect on Gram-positive bacteria and some Gram-negative bacteria, such as Staphylococcus aureus (Auropenicillin Sodium (Potassium) Staphylococcus), pneumococcus, Neisseria gonorrhoeae and Streptococcus, etc. Highly sensitive to this product; meningococcus, diphtheria bacillus, tetanus bacillus and Treponema pallidum are also very sensitive.

[0048] In this example, Puramem Performance type organic solvent-resistant nanofiltration membrane is used for concentration.

[0049] like image 3 As shown in the process flow, 8L of penicillin potassium n-butanol solution with an initial concentration of 5g / L is placed in the storage tank of the membrane separation equipment, and the concentrated solution is transported into a membrane with a 1.8-inch solvent-resistant nanofiltration membrane through the primary pump 2 In the first-stage nanofiltration membrane group 3, adjust the back pressure valve ...

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Abstract

The invention discloses a thermosensitive substance concentration system and a method thereof. The system comprises a primary storage tank, a primary nanofiltration membrane group, a reduced pressuredistillation device and a freeze-drying dehydration device. The method comprises the steps that nanofiltration is carried out on to-be-concentrated liquid for initial concentration, the thermosensitive substances with macromolecules are intercepted for concentration to turn into membrane concentration liquid, and organic solvent with micromolecules is permeated into the other side of membrane to turn into weak liquid or penetrating fluid. The membrane concentration process has the advantages of energy conservation, environmental protection and low emission. The reduced pressure distillation device is adopted to carry out the distilling on the membrane concentration liquid, a small amount of residual organic solvent is further removed, and the freeze-drying process is carried out to removeredundant moisture. According to the system and method, the nanofiltration, the reduced pressure distillation and the freeze-drying dehydration are combined to achieve the thermosensitive substance concentration under the circumstance of organic phase, not only is the problem solved that the membrane separation efficiency is reduced due to excessive substance concentration, but also it can be avoided that when the reduced pressure distillation is carried out on the substance for a long time, the thermosensitive substance is easily decomposed in the concentration and solvent removal process.

Description

technical field [0001] The invention relates to the field of substance concentration methods, in particular to a method for concentrating heat-sensitive substances in an organic solvent phase based on membrane separation technology. Background technique [0002] In the fields of pharmaceutical synthesis, natural extract production, and fine chemical production, organic solvents are commonly used as synthesis, extraction, and extraction media, and the production is faced with the need for solvent removal and product concentration. However, some active pharmaceutical intermediates, natural extracts, and fine chemical products have the characteristics of heat sensitivity. Heat-sensitive substances are a class of substances that are unstable when exposed to heat. They are prone to deterioration reactions such as decomposition, polymerization, and oxidation when exposed to heat, causing heavy economic losses, and should be avoided in industrial production. [0003] In the prior ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D61/02B01D3/10
CPCB01D3/10B01D2311/08B01D61/026B01D2311/2669
Inventor 朱杨阳陈笑媛
Owner 上海飞态环保科技有限公司