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Injection-type high-strength degradable porous magnesium phosphate bone repairing material

A magnesium phosphate bone and repair material technology, applied in the field of medical materials, can solve problems such as poor osseointegration and bone ingrowth, and achieve the effects of promoting bone ingrowth, guiding bone growth, and reducing thermal damage.

Active Publication Date: 2018-11-06
武汉大学人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the deficiencies in the above-mentioned prior art, the main purpose of the present invention is to provide a high-strength magnesium phosphate bone cement material capable of forming holes in the body, which can effectively solve the problems of bone ingrowth and poor osseointegration of dense bone repair scaffolds.

Method used

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  • Injection-type high-strength degradable porous magnesium phosphate bone repairing material
  • Injection-type high-strength degradable porous magnesium phosphate bone repairing material
  • Injection-type high-strength degradable porous magnesium phosphate bone repairing material

Examples

Experimental program
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Effect test

Embodiment 1

[0029] An injection-type high-strength degradable porous magnesium phosphate bone repair material, its process flow diagram is shown in figure 1 , the specific preparation steps are as follows:

[0030] 1) Mix 100 parts (parts by weight, the same below) of sintered magnesium oxide powder, 400 parts of phosphate, 50 parts of calcium phosphate, and 20 parts of retarder (10 parts each of L-lysine and L-tryptophan) , to obtain the solid phase of magnesium phosphate bone cement;

[0031] 2) adding chitosan lactate into deionized water, preparing a water-soluble chitosan solution with a concentration of 10 wt%, shaking evenly to obtain a liquid phase;

[0032] 3) mixing mannitol crystals and sodium alginate in a mass ratio of 1:2 to obtain a pore-forming agent;

[0033] 4) First add a pore-forming agent in the solid phase, and the amount of the pore-forming agent added is 10% of the solid phase mass; then according to the solid-liquid ratio of 1g / ml (the solid-liquid ratio refers ...

Embodiment 2

[0038] The preparation method of the porous magnesium phosphate bone repair material described in this embodiment is roughly the same as in Example 1, except that the solid phase in step 1) consists of 100 parts of sintered magnesium oxide powder, 400 parts of phosphate, 50 parts of calcium phosphate, 40 parts of retarder (20 parts each of L-lysine and L-tryptophan) are mixed, the concentration of chitosan lactate solution is 15wt%, and the pore forming agent consists of mannitol crystals and sodium alginate 2 : 1 mass ratio mixed, the amount of pore forming agent added is 15% of the solid phase mass, and the solid-to-liquid ratio is 2g / ml.

[0039] The final setting time of the porous magnesium phosphate bone repair material obtained in this example is 17.5 minutes; the highest reaction temperature is 43.7° C.; the compressive strength is 43.6 MPa; the porosity is 29.5%.

Embodiment 3

[0041] The preparation method of the porous magnesium phosphate bone repair material described in this embodiment is roughly the same as in Example 1, except that the solid phase in step 1) consists of 100 parts of sintered magnesium oxide powder, 400 parts of phosphate, 50 parts of calcium phosphate, 40 parts of retarder (20 parts each of L-lysine and L-tryptophan) are mixed, the concentration of chitosan hydrochloride solution is 15wt%, and the pore-forming agent consists of mannitol crystals and sodium alginate 1 : 1 mass ratio mixed, the amount of pore forming agent added is 20% of the solid phase mass, and the solid-to-liquid ratio is 2g / ml.

[0042]The final setting time of the porous magnesium phosphate bone repair material obtained in this example was 18.4 minutes; the highest reaction temperature was 44.8° C.; the compressive strength was 37.8 MPa; the porosity was 33.7%.

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Abstract

The invention discloses an injection-type high-strength degradable porous magnesium phosphate bone repairing material. The material includes a solid phase, a liquid phase and a pore forming agent, wherein the solid phase is formed by mixing sintered magnesium oxide, hydrophosphate, calcium phosphate and a retarder; the liquid phase is water-soluble chitosan liquid; the pore-forming agent is formedby mixing mannitol crystals and sodium alginate, wherein the addition amount of the pore forming agent is 10-30% of the mass of the solid phase, and the ratio of the total mass of the pore forming agent and solid phase to the mass of the liquid phase is 0.5-2 g / ml. According to the obtained porous magnesium phosphate bone repairing material, on the basis of introducing a porous structure into a magnesium phosphate bone repairing material system, excellent mechanical performance is ensured; moreover, the material has excellent injectable performance, degradable performance and biocompatibility, less heat is centrally released to the periphery, stable growth of bone repairing cells is facilitated, and the bone repairing material has a significant application and popularization value.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a high-strength magnesium phosphate bone cement material injectable to form holes in the body and a preparation method thereof. Background technique [0002] The traditional methods for clinical treatment of bone defects mainly include autologous bone grafting, allogeneic bone grafting, and implantation of bone substitute materials. Autologous transplantation cannot meet the medical needs of orthopedic transplantation because it is difficult to obtain a sufficient amount of grafted bone, and there may be complications after surgery. Allogeneic transplantation and xenotransplantation are good options, but there are risks such as disease transmission and immune rejection. Synthetic bone graft substitutes are a reasonable choice to meet the rapidly growing demand for orthopedic grafts. Currently, synthetic materials used clinically for bone repair mainly inclu...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/50A61L27/12A61L27/20
CPCA61L27/12A61L27/20A61L27/50A61L27/56A61L2400/06A61L2430/02C08L5/08
Inventor 余铃陶春杰郭卫春
Owner 武汉大学人民医院
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