A kind of methylprednisolone production process and production device

Abstract

The invention discloses a methylprednisolone production device, which comprises a reaction kettle, an elutriation kettle, a centrifugal filtration device, a concentration kettle, a decoloration kettle, a biological fermentation tank and a drying device which are connected in sequence, wherein the drying device comprises an outer cylinder, a drying cylinder and an inner cylinder; a motor is arranged on the bottom surface of the outer cylinder; an exhaust fan blade, a cylinder type impeller and a vortex impeller are arranged on a motor rotating shaft; the exhaust fan blade is arranged between the drying cylinder and the bottom surface of the outer cylinder; the cylinder type impeller is arranged between the drying cylinder and the inner cylinder; the vortex impeller is arranged at the bottomof the inner cylinder; an infrared heating pipe is arranged on the top surface of the inner cylinder; a feeding port is formed in the center of the upper end of the inner cylinder; the side wall of the outer cylinder comprises an inner layer wall and an outer layer wall; an annular interlayer cavity is formed between the inner layer wall and the outer layer wall; an annular baffle is arranged atthe outlet of the upper end of the interlayer cavity, a vent is formed in the baffle, and a rotatable air purification ring is arranged at the upper end of the baffle. According to the method, the preparation time of intermediate products in the production process of the methylprednisolone can be reduced, and rapid and high-quality production of the methylprednisolone can be realized.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical production, in particular to a methylprednisolone production process and a production device. Background technique [0002] Methylprednisolone is a medium-efficiency synthetic product, which belongs to the adrenal cortex hormone drugs in the endocrine system drugs. The anti-inflammatory effect of 4mg is about the same as that of 5mg prednisolone. The sodium retention effect is weak, and it is white or almost white crystalline Powder, odorless, initially tasteless and then bitter. Soluble in absolute ethanol and chloroform, almost insoluble in water, used for first aid for critical illnesses, endocrine disorders, rheumatic diseases, collagen venereal diseases, skin diseases, allergic reactions, eye diseases, gastrointestinal diseases, blood diseases, Leukemia, shock, cerebral edema, polyneuritis, myelitis, and prevention of vomiting caused by cancer chemotherapy. At present, it is mainly u...

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Problems solved by technology

During the production of traditional methylprednisolone, due to the need to adopt multi-step chemical reactions for production, the intermediate product raw materials formed need to be dried multiple times, while the existing drying equipment generally adopts electric resistance wire heating and drying or complete vacuum pumping. Pressure dehumidification, heating and drying of electric heating resistance wire are likely to have a relatively large negative impact on the intermediate product of methylprednisolone preparation, which makes the structure of the intermediate product change, and eventually leads to the instability of subsequent methylprednisolone crystallization and the decrease in purity. Electric resistance wire heating drying equipment or vacuum negative pressure dehumidification equipment have a long drying time. Although vacuum pumping negative pressure dehumidification can achieve rapid dehumidification by rapid decompression, rapid decompression is easy to change the shape and structure of intermediate products. Mutation damage occurs, which reduces the quality of subsequent methylprednisolone production

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