Intestinal protective agent and application thereof
A protective agent and intestinal technology, applied in the field of intestinal protective agent and its application, can solve the problem that the biological activity of the product has not been confirmed by research, and the practical application of egg membrane provides sufficient theoretical basis, biological anti-oxidative stress ability and anti-oxidative stress. The effect of inflammatory activity is unknown and other problems, so as to achieve the effect of broad product market prospect, improvement of disease, and avoidance of side effects.
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Embodiment 1
[0025] Preparation of Tablet A Containing Soluble Eggshell Membrane Hydrolyzate After drying the egg membrane washed with water with hot air, grind it with a pulverizer until the particle size is less than 100 mesh to obtain dried shell membrane powder; take 5g of dried shell membrane powder, add 500mL acetic acid, add 3-mercaptopropionic acid to the suspension to make the concentration 2%, put it in a constant temperature oscillator at 37°C for continuous reaction for 8h, take it out, centrifuge at 8000r / min for 10min, and the supernatant Freeze-drying after concentration to obtain powder;
[0026] Take 20g of the above powder, add 10g of eggshell powder, 25.2g of lactose, 5.0g of β-carotene, 20.05g of vitamin B, 0.05g of vitamin E, 2.0g of niacin, mix well, add 15g of ethanol, and place in a wet granulation device Granulate inside, then dry at 50°C for about 12 hours to obtain granules;
[0027] The granules are mixed with vitamin C and sucrose fatty acid ester in a mass ra...
Embodiment 2
[0029] Composition Tablet B Preparation Containing Eggshell Membrane Powder
[0030] After drying the egg film washed with water with hot air, grind it with a pulverizer until the particle size is less than 100 mesh, and obtain the dried shell film powder; take 20 g of the above-mentioned dried shell film powder, add 10 g of egg shell powder, 25.2 g of lactose, , 5.0g of β-carotene, 20.05g of vitamin B, 0.05g of vitamin E, 2.0g of niacin, mix well, add 15g of ethanol, place in a wet granulation device for granulation, and then dry at 50°C for about 12h , to obtain granules; mix the granules with vitamin C and sucrose fatty acid ester in a mass ratio of 10:1:1, and use a tableting device to make a 200 mg uncoated tablet.
Embodiment 3
[0032] Preparation of Oral Solution C Containing Enzymatic Hydrolyzate of Eggshell Membrane
[0033] After hot air drying the egg film washed with clean water, grind it with a pulverizer until the particle size is less than 100 mesh to obtain dried shell film powder; take 5g of dried shell film powder and add 100mL of 0.4mol / L edible NaOH solution Shake in medium for 3 hours, adjust pH=10, add alkaline protease, react at 55°C for 4 hours, then add neutral protease for 12 hours, heat at 100°C for 10 minutes to terminate the reaction, centrifuge the product at 6000g for 10 minutes, and freeze-dry to obtain eggshell membrane enzymatic hydrolyzate powder;
[0034] Add 20 g of the above powder to 100 mL of distilled water, stir and dissolve at 65°C, filter out impurities and other insoluble matter to obtain a mixed solution A, add 8 g of sucrose to the mixed solution A, and stir thoroughly with a magnetic stirrer for 5 minutes to obtain a mixed solution B, weighing Measure 0.05g p...
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