Modification method for carrying out gaseous polyfluoride grafting on surfaces of membrane type artificial lungs by utilizing low-temperature plasma technology

A low-temperature plasma and gas-phase grafting technology, which is applied in the field of modification of polyfluoride gas-phase grafting, can solve the problem of not being able to completely suppress the rejection reaction of the human body, injecting a large amount of anticoagulant, and poor blood compatibility of polymer membranes, etc. problems, to achieve the effects of excellent gas permeability, improved blood compatibility, and good gas permeability

Inactive Publication Date: 2019-01-08
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the polymer membrane synthesized by a single small molecule has poor blood compatibility, and it can no longer meet the needs of clinical medical applications in today's increasingly demanding performance of artificial organs. surface modification
The traditional membrane surface modification is the application of cheap surface coating method, but this method cannot completely inhibit the rejection reaction of the human body, and a large amount of anticoagulant needs to be injected during the application

Method used

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  • Modification method for carrying out gaseous polyfluoride grafting on surfaces of membrane type artificial lungs by utilizing low-temperature plasma technology
  • Modification method for carrying out gaseous polyfluoride grafting on surfaces of membrane type artificial lungs by utilizing low-temperature plasma technology
  • Modification method for carrying out gaseous polyfluoride grafting on surfaces of membrane type artificial lungs by utilizing low-temperature plasma technology

Examples

Experimental program
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Effect test

specific Embodiment 1

[0028] Clean the poly-4-methyl-1-pentene hollow fiber membrane with deionized water and dry it for 24 hours, then put it into the cavity of the plasma treatment instrument and fix it slightly, and use a vacuum pump to heat the cavity of the gas phase grafting instrument. The operating pressure in the furnace is controlled at about 5Pa, and neon gas (Ne) is introduced for surface activation. The discharge pressure is 40Pa, the irradiation power is 140W, and after the irradiation time is 160s, the plasmaization operation is stopped, and the vacuum pump pumps out the gas in the cavity of the low-temperature plasma processor, and replaces the gas in the cavity with nitrogen. Repeat the above operation three times

[0029] Pour perfluorooctyl ethyl alcohol into the heating cavity of the gas phase grafting instrument, connect the cavity of the low temperature plasma treatment instrument and the heating cavity of the gas phase grafting instrument, and open the valve on the gas phase ...

specific Embodiment 2

[0031] Clean the poly-4-methyl-1-pentene hollow fiber membrane with deionized water and dry it for 24 hours, then put it into the cavity of the plasma treatment instrument and fix it slightly, and use a vacuum pump to heat the cavity of the gas phase grafting instrument. The operating pressure in the furnace is controlled at about 5Pa, and neon gas (Ne) is introduced for surface activation. The discharge pressure is 45Pa, the irradiation power is 150W, and after the irradiation time is 180s, the plasmaization operation is stopped, and the vacuum pump pumps out the gas in the cavity of the low-temperature plasma processor, and replaces the gas in the cavity with nitrogen. Repeat the above operation three times

[0032] Pour perfluoroalkyl ethyl alcohol into the heating cavity of the gas-phase grafting instrument, connect the cavity of the low-temperature plasma treatment instrument and the heating cavity of the gas-phase grafting instrument, and open the valve on the gas-phase ...

specific Embodiment 3

[0034] Clean the poly-4-methyl-1-pentene hollow fiber membrane with deionized water and dry it for 24 hours, then put it into the cavity of the plasma treatment instrument and fix it slightly, and use a vacuum pump to heat the cavity of the gas phase grafting instrument. The operating pressure in the furnace is controlled at about 5Pa, and neon gas (Ne) is introduced for surface activation. The discharge pressure is 35Pa, the irradiation power is 120W, and after the irradiation time is 180s, the plasmaization operation is stopped, and the vacuum pump pumps out the gas in the cavity of the low-temperature plasma processor, and replaces the gas in the cavity with nitrogen. Repeat the above operation three times

[0035] Pour tetrafluoropropanol into the heating cavity of the gas-phase grafting instrument, connect the cavity of the low-temperature plasma treatment instrument and the heating cavity of the gas-phase grafting instrument, open the valve on the gas-phase connecting pi...

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Abstract

The invention discloses a modification method for carrying out gaseous polyfluoride grafting on surfaces of membrane type artificial lungs by utilizing a low-temperature plasma technology. According to the method, a poly-4-methyl-1-pentene (PMP) hollow fibrous membrane is taken as a base membrane material, a low-temperature plasma activation technology is utilized to introduce active sites on thesurface of the PMP membrane, and gaseous grafting is carried out on polyfluorides such as acids, alcohols, olefins, esters and ketones. According to the method, gaseous modified grafting is carried out on PMP base membranes by applying the low-temperature plasma technology, so that the surfaces of the base membranes have certain super-hydrophobicity, the energy consumption is less, the efficiencyis high, the biocompatibility of the modified PMP membranes is remarkably improved and the gas transmission performance is improved; and the method has a wide application prospect in biochemical treatment.

Description

technical field [0001] The present invention relates to the modification method of the polymer hollow fiber membrane that is used for membrane type artificial lung, be specifically related to a kind of for promoting the blood compatibility of poly-4-methyl-1-pentene (referred to as PMP) film and oxygen- Selective permeability of carbon dioxide, using low-temperature plasma technology to modify the surface of PMP membrane material with polyfluoride gas phase grafting. technical background [0002] Artificial lung, also known as oxygenator, integrates the functions of oxygenation, temperature change, blood storage, filtration, and blood recovery. It converts venous blood with low oxygen content into arterial blood with high oxygen content after oxygenation. It is an ideal artificial organ that is close to the physiological state of the human body. Membrane artificial lungs have been widely used in extracorporeal circulation in cardiovascular surgery, and also in rescue treatm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/26B01D69/08B01D67/00
CPCB01D67/0006B01D69/08B01D71/26
Inventor 李磊汤天乙许梦菲
Owner NANJING UNIV
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