Agarose hydrogel microsphere, and preparation method and application thereof

A kind of technology of agarose hydrogel and microspheres, which is applied in the direction of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve limited problems, chronic poisoning heavy metal removal ability and other problems, achieve convenient operation, avoid adverse reactions, and prepare The effect of simple method

Inactive Publication Date: 2019-01-29
泉州三欣新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is that, aiming at the problem of chronic poisoning caused by heavy metal pollution of people's skin in current life and the problem of limited ability to remove heavy metals from the surface of hum...

Method used

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  • Agarose hydrogel microsphere, and preparation method and application thereof
  • Agarose hydrogel microsphere, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Activation of agarose hydrogel microspheres

[0035]Mix 100g of agarose hydrogel microspheres with 1000g of 1mol / L sodium hydroxide aqueous solution, add 200g of dimethylformamide and 50g of epichlorohydrin in sequence, stir and react at 45°C for 4h, wash and purify, and obtain epoxy Epoxidized agarose hydrogel microspheres with a base content of 800 μmol / g;

[0036] (2) Preparation of agarose hydrogel microspheres

[0037] The epoxidized agarose hydrogel microsphere that 100g step (1) obtains is mixed with heavy metal binding agent (8g lipoic acid and 8g diethylenetriamine pentaacetic acid), 1000g water, adds catalyst N,N-dimethyl Benzylamine was stirred and reacted at 70° C. for 8 hours, wherein the mass fraction of the catalyst in the solution was 0.05 wt %; purified to obtain agarose hydrogel microspheres with particle diameters ranging from 0.02 mm to 1 mm.

Embodiment 2

[0039] (1) Activation of agarose hydrogel microspheres

[0040] Mix 100g of agarose hydrogel microspheres with 100g of 2mol / L aqueous sodium hydroxide solution, add 10g of dimethylformamide and 80g of epichlorohydrin in sequence, stir and react at 40°C for 5h, wash and purify, and obtain epoxy Epoxidized agarose hydrogel microspheres with a base content of 700 μmol / g;

[0041] (2) Preparation of agarose hydrogel microspheres

[0042] The epoxidized agarose hydrogel microsphere that 100g step (1) obtains is mixed with heavy metal binding agent (20g lipoic acid and 40g ethylenediaminetetraacetic acid), 10000g water, adds catalyst tetrabutyl ammonium bromide, at 80 ℃ Stirring and reacting for 5 hours under the conditions, wherein the mass fraction of the catalyst in the solution is 0.5 wt %; purifying to obtain agarose hydrogel microspheres with particle diameters ranging from 0.02 mm to 1 mm.

Embodiment 3

[0044] (1) Activation of agarose hydrogel microspheres

[0045] Mix 100g of agarose hydrogel microspheres with 50,000g of 1.5mol / L sodium hydroxide aqueous solution, add 30,000g of dimethylformamide and 100g of epichlorohydrin in sequence, stir and react at 20°C for 10h, wash and purify, and obtain ring Epoxidized agarose hydrogel microspheres with an oxygen content of 600 μmol / g;

[0046] (2) Preparation of agarose hydrogel microspheres

[0047] Mix 100 g of epoxidized agarose hydrogel microspheres obtained in step (1) with heavy metal binders (10 g of lipoic acid and 5 g of polyaspartic acid) and 100 g of water, add catalyst triethanolamine, and stir the reaction at 70 ° C 12h, wherein, the mass fraction of the catalyst in the solution is 0.2wt%; purify to obtain agarose hydrogel microspheres with a particle size between 0.02mm and 1mm.

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Abstract

The invention discloses an agarose hydrogel microsphere prepared by compounding an agarose hydrogel and a heavy metal binding agent. According to the invention, lipoic acid and a polycarboxyl compoundare compounded to form a compound heavy-metal chelating agent which is grafted and immobilized on the agarose hydrogel microsphere so as to give full play to the synergistic effect of the lipoic acidand the polycarboxyl compound on removal of heavy metals, so the agarose hydrogel microsphere with a heavy metal binding function is obtained. As the agarose hydrogel microsphere with the heavy metalbinding function is applied to cosmetics or medicines for binding to toxic heavy metals on the surface of skin, the toxic heavy metals on the surface of skin can be effectively, rapidly and selectively bound and removed, and the agarose hydrogel microsphere has high selectivity, large adsorption capacity and high adsorption rate and can avoid adverse reactions in oral administration of detoxification drugs; and a preparation method for the agarose hydrogel microsphere in the invention has the advantages of simple process, convenient operation and good material stability, and the prepared agarose hydrogel microsphere has a wide application scope and practical application value.

Description

technical field [0001] The present invention relates to a kind of agarose hydrogel microsphere and its preparation method and application, specifically, relate to a kind of agarose agarose hydrogel microsphere grafted with lipoic acid and polycarboxy compound and its preparation method and in Pharmaceutical or cosmetic applications. Background technique [0002] With the rapid development of industrialization, heavy metal pollution has become a social concern. Generally speaking, heavy metal pollution refers to the pollution of heavy metal ions such as lead, mercury, cadmium, and arsenic. Due to the random discharge of industrial wastewater, waste gas, and waste residues, as well as the abuse of agricultural pesticides and fertilizers, a large number of toxic heavy metal ions pollute through water, air, soil, and biological chains to animal and plant products and water sources that human beings rely on for survival. cause potential harm. In addition, in daily life, some d...

Claims

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Application Information

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IPC IPC(8): C08J7/12A61K31/729A61P17/16A61K8/73A61Q19/00A61P39/02C08L5/12
CPCA61K8/73A61K31/729A61P17/16A61P39/02A61Q19/00C08J7/12C08J2305/12
Inventor 刘云鸿彭新艳刘云晖
Owner 泉州三欣新材料科技有限公司
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