Preparation method of temperature-controlled intelligent drug release system based on titanium dioxide nanotube array
A technology of nanotube array and titanium dioxide, which is applied in the fields of pharmaceutical formulation, drug delivery, medical science, etc., to achieve the effect of high drug utilization
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0024] Titanium as the substrate, sanded to smooth with metallographic sandpaper, ultrasonically cleaned in acetone and cleaned in HF and HNO 3 etched in a mixed acid solution (volume ratio 1:15), rinsed with distilled water and ultrasonicated, and dried at 50°C. The pretreated titanium sheet is used as the anode, the platinum sheet is used as the cathode, and the glycerin / water (glycerol to water volume ratio 1:7) system containing 0.30wt% ammonium fluoride is used as the electrolyte solution. After anodic oxidation at 60V for 24h , take it out, wash it with distilled water, and dry it in the air to get the titanium dioxide nanotube array, the microscopic morphology is as follows Figure 1a , Figure 1b As shown, the nanotubes are closely arranged and regular, and the diameter of the tube is about 210nm.
Embodiment 2
[0026] Titanium as the substrate, sanded to smooth with metallographic sandpaper, ultrasonically cleaned in acetone and cleaned in HF and HNO 3 etched in a mixed acid solution (volume ratio 1:15), rinsed with distilled water and ultrasonicated, and dried at 50°C. The pretreated titanium sheet is used as the anode, the platinum sheet is used as the cathode, and the glycerin / water (glycerol to water volume ratio 1:7) system containing 0.30wt% ammonium fluoride is used as the electrolyte solution. After anodic oxidation at 60V for 24h , take it out, wash it with distilled water, and dry it in the air to get the titanium dioxide nanotube array, the microscopic morphology is as follows Figure 1a , Figure 1b As shown, the nanotubes are closely arranged and regular, and the diameter of the tube is about 210nm.
[0027] Heat 0.01g of ibuprofen (IBU) and 0.02g of tetradecyl alcohol (TD) in a water bath at 50°C, and keep stirring until the two are moderate and uniform, then place the...
Embodiment 3
[0029] Titanium as the substrate, sanded to smooth with metallographic sandpaper, ultrasonically cleaned in acetone and cleaned in HF and HNO 3 etched in a mixed acid solution (volume ratio 1:15), rinsed with distilled water and ultrasonicated, and dried at 50°C. The pretreated titanium sheet is used as the anode, the platinum sheet is used as the cathode, and the glycerin / water (glycerol to water volume ratio 1:7) system containing 0.30wt% ammonium fluoride is used as the electrolyte solution. After anodic oxidation at 60V for 24h , take it out, wash it with distilled water, and dry it in the air to get the titanium dioxide nanotube array, the microscopic morphology is as follows Figure 1a , Figure 1bAs shown, the nanotubes are closely arranged and regular, and the diameter of the tube is about 210nm.
[0030] Heat 0.1g IBU and 0.2g TD in a 50°C water bath, and keep stirring until the two are moderate and uniform, and place them in a water bath to maintain 50°C to obtain a...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More