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Preparation method of dental restoration modified nano-hydroxyapatite composite material

A nano-hydroxyapatite, composite material technology, applied in dental preparations, phosphorus compounds, nanotechnology and other directions, can solve the problems of unfavorable anti-caries repair, poor antibacterial performance of nHAP, high crystallinity and structural stability, and achieve biological Easy retention of activity, in situ repair, good antibacterial effect

Inactive Publication Date: 2019-03-08
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Synthetic nHAP has poor antibacterial properties, high crystallinity and structural stability, which is not conducive to the role of caries prevention and restoration

Method used

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  • Preparation method of dental restoration modified nano-hydroxyapatite composite material
  • Preparation method of dental restoration modified nano-hydroxyapatite composite material
  • Preparation method of dental restoration modified nano-hydroxyapatite composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Weigh 3.542g of calcium nitrate tetrahydrate and dissolve it in 400ml of deionized water. After fully dissolving, add 1.126g of glycine and 1.997g of aspartic acid respectively to make solution A for later use; the molar ratio of soluble calcium salt to compound amino acid It is 1:2.

[0026] (2) Weigh 1.186g of diammonium hydrogen phosphate and dissolve it in 200ml of deionized water, add 0.0593g of graphene oxide powder, ultrasonically disperse evenly, and prepare solution B for later use, in which the mass ratio of soluble phosphate to graphene oxide is 1: 0.05.

[0027] (3) Prepare a pH regulator with a sodium hydroxide concentration of 0.02mol / L for use.

[0028] (4) Add solution A and solution B into a 1L autoclave in sequence under stirring (the stoichiometric ratio of Ca / P in soluble calcium salt and soluble phosphate is 1.67), and adjust the pH value of the reaction solution to 9.0~10.0.

[0029] (5) After hydrothermal reaction in a high-pressure reactor...

Embodiment 2

[0032] (1) Weigh 3.542g of calcium nitrate tetrahydrate and dissolve it in 400ml of deionized water. After fully dissolving, add 0.105g of serine and 0.076g of glutamic acid respectively to prepare solution A for use. The molar ratio of soluble calcium salt to compound amino acid is 1:0.1.

[0033] (2) Weigh 1.186g of diammonium hydrogen phosphate and dissolve it in 200ml of deionized water to make solution B for later use.

[0034] (3) Prepare a pH regulator with a sodium hydroxide concentration of 0.02mol / L for use.

[0035] (4) Add solution A and solution B into a 1L autoclave in sequence under stirring (the stoichiometric ratio of Ca / P in soluble calcium salt and soluble phosphate is 1.67), and adjust the pH value of the reaction solution to 10.0~11.0.

[0036] (5) After hydrothermal reaction in a high-pressure reactor at 120°C for 12 hours, cool down, wash the reaction suspension until the pH of the supernatant is neutral, filter and freeze-dry it to prepare amino acid-...

Embodiment 3

[0039] (1) Weigh 3.542g of calcium nitrate tetrahydrate and dissolve it in 400ml of deionized water. After fully dissolving, add 3.153g of serine, 4.414g of glutamic acid and 3.994g of aspartic acid to make solution A for later use. The soluble calcium salt The molar ratio with compound amino acid is 1:6.

[0040] (2) Weigh 1.186g of diammonium hydrogen phosphate and dissolve it in 200ml of deionized water, add 0.1186g of graphene oxide powder, ultrasonically disperse evenly, and prepare solution B for later use, in which the mass ratio of soluble phosphate to graphene oxide is 1: 0.1.

[0041] (3) Prepare a pH regulator with a sodium hydroxide concentration of 0.02mol / L for use.

[0042] (4) Add solution A and solution B into a 1L autoclave in sequence under stirring (the stoichiometric ratio of Ca / P in soluble calcium salt and soluble phosphate is 1.67), and adjust the pH value of the reaction solution to 8.0~9.0.

[0043] (5) After hydrothermal reaction in an autoclave a...

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Abstract

The invention discloses a preparation method of a dental restoration modified nano-hydroxyapatite composite material and belongs to the field of biomedical materials. The dental restoration modified nano-hydroxyapatite composite material is prepared by taking soluble calcium salt and soluble phosphate salt as raw materials and compound amino acids and / or graphene oxide as a modification means through a hydrothermal method. The dental restoration modified nano-hydroxyapatite composite material is structurally characterized in an enamel-like nanorod structure with a particle diameter of 3-30 nmand a particle length of 50-300 nm and is low in degree of crystallinity. The dental restoration modified nano-hydroxyapatite composite material has the advantages of being good in biosecurity and high in biocompatibility, achieving good restoration effects on surface decalcification and deep decalcification of enamel or dentin and forming new remineralized restoration layers by nucleation on thesurface of decalcified enamel or dentin, thereby improving the surface hardness and the antibacterial performance of teeth and providing new possibility for clinical tooth remineralization restoration.

Description

technical field [0001] The invention relates to a preparation method of a modified nano-hydroxyapatite composite material for tooth restoration; it belongs to the field of biomedical materials. Background technique [0002] Teeth are morphological, highly calcified tissues that function in chewing, aiding in pronunciation, and maintaining facial shape. The part of the tooth that is exposed to the oral environment is enamel, the white, translucent tissue that is the hardest substance in the human body. Its unique mechanical properties are attributed to the prismatic structure of parallel micro- and nano-scale hydroxyapatite glaze columns interleaved with a softer protein matrix. The formation of enamel is a process of cell-mediated extracellular mineralization. With the maturation of minerals, cell apoptosis is accompanied by the continuous decomposition of organic substances such as amelogenin, and finally a tooth with a mineral content of 92-96wt% is obtained. enamel. Th...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y40/00A61K6/00A61K6/02
CPCB82Y40/00C01B25/325C01P2004/16C01P2004/03C01P2004/04C01P2002/82C01P2002/72C01P2004/80A61K6/80A61K6/20
Inventor 陈庆华刘继涛颜廷亭陈希亮
Owner KUNMING UNIV OF SCI & TECH
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