Anti-bacterial peptide, anti-bacterial peptide hydrogel and preparation method of anti-bacterial peptide hydrogel

An antimicrobial peptide and hydrogel technology, applied in the field of biopharmaceuticals, can solve the problem that mechanical debridement cannot completely remove biofilm, and achieve the effect of promoting rapid healing and promoting growth and proliferation
CN109456389AActive Publication Date: 2019-03-12SUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU UNIV
Publication Date
2019-03-12

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Abstract

The invention relates to the technical field of biological pharmacy, in particular to an anti-bacterial peptide, an anti-bacterial peptide hydrogel and a preparation method of the anti-bacterial peptide hydrogel. The amino acid sequence of the anti-bacterial peptide is shown as SEQ ID NO:1. Experiments show that the polypeptide of the anti-bacterial peptide has high antibacterial activity and excellent biocompatibility. The anti-bacterial peptide hydrogel is made of the anti-bacterial peptide, a photo-thermal reagent and a wound growth promoting factor. Tests show that the anti-bacterial peptide hydrogel has a good killing effect on bacteria, especially drug-resistant bacteria, on the surface of a biological film, a bacterial biofilm can be effectively spitted and removed, growth and proliferation of wound epidermal cells, collagen formation and angiogenesis are facilitated, and rapid healing of wounds infected by the bacterial biofilm is achieved.
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Description

technical field

[0001] The invention relates to the technical field of biopharmaceuticals, in particular to an antimicrobial peptide, an antimicrobial peptide hydrogel and a preparation method thereof. Background technique

[0002] After human skin is injured, normal tissue healing will go through processes such as hemostasis, inflammation, proliferation and tissue remodeling. The series of wound healing processes are not only complicated, but also fragile, and are easily disturbed by various factors and stagnated, thus forming chronic wounds. Chronic wound infection constitutes 60-80% of human infectious diseases. In addition, with the aging of the social population and the increasing prevalence of diseases such as diabetes and obesity, chronic wounds have become one of the main problems of global health. Bacterial biofilm infection is relatively common in chronic wounds. Bacterial biofilm refers to the membrane-like bacterial colony formed by bacteria adhering to the sur...

Claims

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