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Application of bioactive glass coated particles to oral care products

A bioactive glass, oral care technology, applied in oral care, drug combination, cosmetic preparations, etc., can solve the problems of harsh process conditions, poor colloidal appearance and foaming performance, difficult formulation design, etc., and achieve anti-dentin hypersensitivity. , The effect of preventing dental caries and reducing plaque

Pending Publication Date: 2019-03-19
苏州绿叶日用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the characteristics of bioactive glass, phosphorus and calcium ions will be released when it meets water to achieve its therapeutic effect. Therefore, it is required that the formula does not contain water, and the anhydrous formula has disadvantages such as difficult formula design, harsh process conditions, colloidal appearance and poor foaming performance. place

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take the preparation of toothpaste with bioactive glass-encapsulated particles as an example:

[0030] 1) The formula of biologically active coated granules: it is composed of the following components in parts by weight: 90 parts of active ingredients, 10 parts of encapsulating aids, the active ingredient is bioactive glass, and the encapsulating aids are composed of denatured cornstarch, microcrystalline cellulose And PVA composition.

[0031] 2) Toothpaste formula: 60.0 parts of sorbitol, 10.0 parts of glycerin, 10.0 parts of polyethylene glycol-8, 10.0 parts of hydrated silica, 0.1 part of sodium lauryl sulfate, 0.01 part of bioactive glass-coated particles, cellulose gum 1.5 parts, 0.01 parts of sodium saccharin, 1 part of titanium dioxide, 0.24 parts of sodium fluoride, 0.5 parts of sodium benzoate, 0.1 parts of food flavor, and add water to the balance to 100 parts.

Embodiment 2

[0033]Take the preparation of toothpaste with bioactive glass-encapsulated particles as an example:

[0034] 1) The formula of biologically active coated particles: it is composed of the following components in parts by weight: 50 parts of active ingredients, 50 parts of coating aids, the active ingredients are bioactive glass and bamboo charcoal powder, and the coating aids are composed of mannitol, hydroxyl Composition of propyl methylcellulose and PVA.

[0035] 2) Toothpaste formula: 10.0 parts of glycerin, 50.0 parts of calcium hydrogen phosphate, 5.0 parts of hydrated silica, 1.0 parts of sodium lauryl sulfate, 5.0 parts of cocamidopropyl betaine, 5.0 parts of bioactive glass-coated particles, 0.5 parts of cellulose gum 0.2 parts of carrageenan, 0.4 parts of sodium saccharin, 10.0 parts of green tea extract, 0.05 parts of sodium hydroxide, 0.2 parts of sodium benzoate, 3.0 parts of food flavor, and add water to the balance to 100 parts. The components of bioactive glass-...

Embodiment 3

[0037] Take the preparation of toothpaste with bioactive glass-encapsulated particles as an example:

[0038] 1) The formulation of bioactive coated granules: it consists of the following components in parts by weight: 0.01 part of active ingredient, 99.9 parts of encapsulating auxiliary agent, the active ingredient is composed of bioactive glass and tea polyphenol, and the encapsulating auxiliary agent is composed of mannitol , corn starch and microcrystalline cellulose.

[0039] 2) Toothpaste formula: 20.0 parts of sorbitol, 6.0 parts of polyethylene glycol-8, 18.0 parts of hydrated silica, 2 parts of sodium lauroyl sarcosinate, 5.0 parts of bioactive glass-coated particles, 0.5 parts of xanthan gum, 10.0 parts of strontium acetate, 5.0 parts of sodium tripolyphosphate, 5.0 parts of hydroxyapatite, 0.2 parts of sodium saccharin, 1.0 parts of food flavor, and add water to the balance to 100 parts.

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PUM

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Abstract

The invention discloses bioactive glass coated particles. The coated particles are prepared from, by weight, 0.01-90 parts of an active component and 10-99.99 parts of a coating auxiliary agent, wherein the active component refers to bioactive glass or a composition of bioactive glass and other active components. The invention further discloses application of the bioactive glass coated particles to oral care products such as toothpaste, oral care solution and oral care gel. In use of the oral care products, active substances such as the bioactive glass are released after the coated particles are broken. The oral care products have efficacies of dentine hypersensitivity resisting, whitening, dental decay preventing, dental plaque reducing, gingivitis alleviating and the like.

Description

technical field [0001] The invention relates to an oral care product, in particular to an oral care product containing bioactive glass-coated particles. Background technique [0002] Oral diseases are common and frequently-occurring diseases that affect human health. Common oral diseases mainly include dental caries, gingivitis, periodontal disease, dentin sensitivity and oral ulcers. The harmfulness of chronic non-communicable diseases to the health of the population has attracted human attention, and the prevention and treatment of oral diseases is one of the important topics of life science research in the future. [0003] Bioactive glass is composed of a variety of inorganic ions, including silicon, calcium, sodium and phosphorus, etc., which react in aqueous solution or saliva environment. On the one hand, bioactive glass releases calcium and phosphorus ions, which can increase the pH of the solution. Porphyromonas gingivalis and Fusobacterium nucleatum have antibacte...

Claims

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Application Information

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IPC IPC(8): A61K8/9794A61K8/9789A61K8/46A61K8/44A61K8/365A61K8/36A61K8/34A61K8/25A61K8/24A61K8/22A61K8/21A61K8/20A61K8/19A61Q11/00A61P1/02A61P31/02A61P31/04
CPCA61K8/9794A61K8/19A61K8/20A61K8/21A61K8/22A61K8/24A61K8/25A61K8/34A61K8/347A61K8/36A61K8/365A61K8/44A61K8/466A61K8/9789A61K2800/592A61P1/02A61P31/02A61P31/04A61Q11/00
Inventor 张灵艳刘冬
Owner 苏州绿叶日用品有限公司
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