Antibacterial and biocompatible bone implantation material and preparation method and application thereof

A bone implant material and biocompatibility technology are applied in the field of antibacterial and biocompatible bone implant materials and their preparation, which can solve the problems of affecting the antibacterial properties of the material, affecting the surface potential of the material, and failing to kill bacteria. , to achieve excellent antibacterial activity and biological activity, enhance binding force, and maintain the effect of surface mechanical strength

Active Publication Date: 2019-07-12
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
View PDF5 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method introduces a large amount of hydrogen and oxygen elements, which affects the surface potential of the material and cannot achieve the effect of killing bacteria. I...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]The preparation of antibacterial and biocompatible PEEK bone implant material comprises the following steps:

[0040] 1) Place the PEEK bone implant material in the injection cavity of the plasma injection equipment, inject 1.0×10 PEEK bone implant material 10 A dose of argon plasma was used for pretreatment, the injection voltage was 5KV, and the pressure in the cavity was kept at 1.0×10 -1 Pa, close the ion implanter after the injection, and keep the pressure in the injection chamber at 1.0×10 -1 Pa, keep the pressure for 1min;

[0041] 2) Choose graphite as the carbon plasma source, seal and vacuumize, the vacuum degree is 1.0×10 -1 Pa, then turn on the power of the ion implanter, adjust the accelerating voltage of the ion implanter to 5KV, and control the injection time to make the carbon plasma flow at 1.0×10 10 ions / cm 2 The dosage of the PEEK bone implant material is injected into the surface of the PEEK bone implant material to form a stable transition layer ...

Embodiment 2

[0045] The preparation of antibacterial and biocompatible zirconia ceramic bone implant material comprises the following steps:

[0046] 1) Place the zirconia ceramic bone implant material in the injection chamber of the plasma implantation equipment, select amorphous carbon as the carbon plasma source, seal and vacuumize, and the vacuum degree is 1.0×10 -4 Pa, then turn on the power of the ion implanter, adjust the accelerating voltage of the ion implanter to 8KV, and control the implantation time to make the carbon plasma 20 ions / cm 2 The dosage is injected into the surface of the zirconia ceramic implant and forms a stable transition layer with a carbon chemical structure. The mass percentage of carbon in the stable transition layer is higher than 50%. During the injection process, the pressure in the cavity is kept at 1.0×10 -4 Pa, turn off the power of the injection machine after the injection, and keep the pressure in the injection chamber at 1.0×10 -4 Pa, keep the pre...

Embodiment 3

[0050] The preparation of antibacterial and biocompatible titanium alloy bone implant material comprises the following steps:

[0051] 1) Put the titanium alloy bone implant material in the injection chamber of the plasma implantation equipment, choose graphite as the carbon plasma source, seal and vacuumize, the vacuum degree is 1.0×10 -6 Pa, then turn on the power of the ion implanter, adjust the accelerating voltage of the ion implanter to 12KV, and control the implantation time to make the carbon plasma 15 ions / cm 2 The dosage is injected into the surface of the titanium alloy implant and forms a stable transition layer with a carbon chemical structure. The mass percentage of carbon in the stable transition layer is higher than 50%, and the intracavity pressure is maintained at 1.0×10 during the injection process. -6 Pa, turn off the power of the injection machine after the injection, and keep the pressure in the injection chamber at 1.0×10 -6 Pa, hold pressure for 60 mi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Thicknessaaaaaaaaaa
Thicknessaaaaaaaaaa
Thicknessaaaaaaaaaa
Login to view more

Abstract

The invention discloses an antibacterial and biocompatible bone implantation material and a preparation method and application thereof. The antibacterial and biocompatible bone implantation material comprises a bone implantation material body and a composite antibacterial layer formed on the surface of the bone implantation material body; the composite antibacterial layer is obtained by injectinga carbon-containing plasma or a silicon-containing plasma into a surface layer of the bone implantation material body to obtain a transition layer and then injecting a nitrogen-containing plasma or aphosphorus-containing plasma into the transition layer; the carbon-containing plasma, the silicon-containing plasma, the nitrogen-containing plasma and the phosphorus-containing plasma all do not contain hydrogen and oxygen; the relative surface potential of the antibacterial and biocompatible bone implantation material is 0.01-0.5 V. The antibacterial and biocompatible bone implantation materialand the preparation method and application thereof have the advantages that a plasma injection technology is adopted to construct the high potential surface, and the antibiosis and biosecurity are given to the surface of the bone implantation material.

Description

technical field [0001] The invention relates to the technical field of biomedical materials. More specifically, it relates to an antibacterial and biocompatible bone implant material and its preparation method and application. Background technique [0002] Implant materials mainly include joint replacement, bone plate, bone implant materials, and dental implant materials. Since the implant materials themselves do not have antibacterial and anti-infection capabilities, they are prone to bacterial colonization during clinical use and induce tissue inflammation. The method of inflammation around the bone implant material has the disadvantages of short action time and easy drug resistance. Therefore, antibacterial modification to enhance its antibacterial and anti-infection capabilities is the main method to prevent peri-implant inflammation and improve the success rate of clinical application. [0003] However, the current methods of endowing bone implant materials with antib...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L27/30A61L27/06A61L27/10A61L27/18A61L27/54
CPCA61L27/06A61L27/10A61L27/18A61L27/30A61L27/54A61L2300/10A61L2300/404A61L2300/608A61L2430/02C08L61/16
Inventor 张维刘可刘军
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products