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Photosensitizer combined with laser and preparation method and application thereof

A photosensitizer and laser technology, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, parts of surgical instruments, etc., can solve the problems that the transdermal enhancer is difficult to obtain the effect of promoting penetration, is not suitable, and affects drugs, etc. , to achieve good thermal stability, increase hydrophilicity, and large drug loading effect

Inactive Publication Date: 2019-07-26
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When local drug administration is used for treatment, the entry of drugs or light is affected, and it is difficult for traditional drug penetration-enhancing technologies such as skin-penetration enhancers to obtain ideal penetration-enhancing effects
Physical penetration-enhancing techniques, such as microneedling, are more suitable for elastic and flat skin, but not suitable for the hard and uneven scab surface of basal cell carcinoma

Method used

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  • Photosensitizer combined with laser and preparation method and application thereof
  • Photosensitizer combined with laser and preparation method and application thereof
  • Photosensitizer combined with laser and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation method of the photosensitizer used in combination with laser comprises the following steps:

[0034] Step 1. Stir after mixing 3.3 parts by weight of 4-nitrophthalonitrile and 100 parts by weight of tetrahydrofuran, then add 3.3 parts by weight of 4-hydroxybenzoic acid and stir to obtain the first mixed solution; Add 34 parts by weight of anhydrous K to the first mixed solution at room temperature 2 CO 3 React and stand still for 72 hours to obtain the second mixed solution; first mix the second mixed solution with ice water at a volume ratio of 1:2, adjust to pH = 1, and then keep it in the dark for 12 hours, then filter under reduced pressure, and then use ultra- Wash the filter cake with pure water until neutral, dry the filter cake under reduced pressure at 45°C for 12 hours, collect the residue on the filter cake to obtain 4-(4-carboxyphenoxy)phthalonitrile;

[0035]Step 2. Place 0.2658 parts by weight of 4-(4-carboxyphenoxy) phthalonitrile prepar...

Embodiment 2

[0039] The preparation method of the photosensitizer used in combination with laser comprises the following steps:

[0040] Step 1. Stir after mixing 3.5 parts by weight of 4-nitrophthalonitrile and 100 parts by weight of tetrahydrofuran, then add 3.4 parts by weight of 4-hydroxybenzoic acid and stir to obtain the first mixed solution; Add 35 parts by weight of anhydrous K to the first mixed solution at room temperature 2 CO 3 React and stand still for 72 hours to obtain the second mixed solution; first mix the second mixed solution with ice water at a volume ratio of 1:2, adjust to pH = 1, and then keep it in the dark for 12 hours, then filter under reduced pressure, and then use ultra- Wash the filter cake with pure water until neutral, dry the filter cake under reduced pressure at 45°C for 12 hours, collect the residue on the filter cake to obtain 4-(4-carboxyphenoxy)phthalonitrile;

[0041] Step 2. Place 0.2658 parts by weight of 4-(4-carboxyphenoxy) phthalonitrile prepa...

Embodiment 3

[0045] The preparation method of the photosensitizer used in combination with laser comprises the following steps:

[0046] Step 1. Stir after mixing 3.4664 parts by weight of 4-nitrophthalonitrile and 100 parts by weight of tetrahydrofuran, then add 3.3207 parts by weight of 4-hydroxybenzoic acid and stir to obtain the first mixed solution; Add 34.0385 parts by weight of anhydrous K to the first mixed solution at room temperature 2 CO 3 React and stand still for 72 hours to obtain the second mixed solution; first mix the second mixed solution with ice water at a volume ratio of 1:2, adjust to pH = 1, and then keep it in the dark for 12 hours, then filter under reduced pressure, and then use ultra- Wash the filter cake with pure water until neutral, dry the filter cake under reduced pressure at 45°C for 12 hours, collect the residue on the filter cake to obtain 4-(4-carboxyphenoxy)phthalonitrile;

[0047] Step 2. Place 0.2658 parts by weight of 4-(4-carboxyphenoxy) phthaloni...

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PUM

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Abstract

The invention discloses a photosensitizer combined with a laser. The photosensitizer uses a cubic liquid crystal as a carrier. A main drug of the photosensitizer combined with the laser is tetracarboxylic zinc phthalocyanine, and a chemical formula is in the description below, wherein a small angle X-ray diffraction peak position ratio of the photosensitizer is in the description below, the lasercombined with the photosensitizer comes from a CO2 laser, specific parameters of the CO2 laser are as follows: the radiant energy of the CO2 laser is 238 mJ / cm<2>, the optimal irradiation power is 150mW, the optimal irradiation time is 5 min, and the dark incubation time is 4 h. The invention further provides a method for preparing the photosensitizer combined with a laser and application of thephotosensitizer combined with a laser as a medicament for treating basal cell carcinoma.

Description

technical field [0001] The invention relates to the field of clinical treatment of basal cell carcinoma, in particular to a photosensitizer combined with laser and its preparation method and application. Background technique [0002] The incidence of basal cell carcinoma accounts for about 75% of skin tumors. Most of the patients are elderly. They are often malignant at the time of clinical diagnosis. Due to psychological and physical reasons, surgical treatment is generally not selected. In the early stage of the disease, macular papules with a hard base or verrucous protrusions gradually ulcerate to form ulcers. The clinical treatment methods for basal cell carcinoma include radiotherapy, external cytotoxic drug therapy, liquid nitrogen freezing, laser therapy and photodynamic therapy, among which local drug therapy and carbon dioxide laser therapy are more popular due to their advantages of small damage, obvious effect and local effect. Pay attention to. Basal cell carc...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/00A61P35/00C07D487/22A61B18/20
CPCA61B18/20A61B2018/00595A61B2018/00601A61K9/0014A61K9/0087A61K41/0071A61P35/00C07D487/22
Inventor 杜丽娜金义光麻培培
Owner ACADEMY OF MILITARY MEDICAL SCI