Allogeneic demineralized bone material used for nose job filling and preparation method thereof

Abstract

The invention provides an allogeneic demineralized bone material used for nose job filling and a preparation method thereof. The method comprises the steps of using a human cortical bone as a raw material, and taking the cortical bone of a middle segment of a tibia or a femur to prepare a cortical bone lamella with thickness of 2-10 mm, width of 15-50 mm and length of 20-80 mm; drilling the cortical bone on a drilling machine evenly, wherein holes are through holes or non-through holes; adopting a chloroform / methyl alcohol (1 to 1) solution for conducting room-temperature soak degreasing on the cortical bone with the holes; soaking the cortical bone with the holes in purified water at 60+ / -1 DEG C for 10 h to conduct virus inactivation; conducting demineralization treatment in hydrochloricacid or acetic acid by means of an ultrasonic method, conducting ultrasonic cleaning on the demineralized cortical bone by means of purified water, and replacing the purified water hourly until a cleaning liquid pH is 5.8-7.5; conducting freeze-drying treatment on the demineralized cortical bone; and adopting at least two layers of bacteria-isolating plastic bags for packaging the freeze-dried cortical bone, and conducting irradiation sterilization. The method is simple in preparation process, the structure is stable, the biocompatibility is good, shaping is easy, complications of translocation and the like are not liable to happen, and finally, the allogeneic demineralized bone material used for nose job filling can be replaced by self-tissue.

Description

technical field [0001] The invention belongs to the technical field of plastic surgery, and in particular relates to a same demineralized bone material used for nasal plastic filling and a preparation method thereof. Background technique [0002] Rhinoplasty (facelift) surgery is the most common surgery in the field of plastic surgery by implanting appropriate materials to change the height and shape of the nose so that it harmonizes with other parts of the face. [0003] At present, the commonly used implant materials in rhinoplasty include autologous bone, homogeneous costal cartilage, medical silica gel, expanded polytetrafluoroethylene, hyaluronic acid, etc. [0004] Since autologous bone comes from itself, it has good histocompatibility and is not prone to rejection. However, the process of obtaining autologous bone may cause complications at the donor site of the graft and there is a risk of bone resorption. [0005] The same type of costal cartilage has good biocompa...

AI Technical Summary

Problems solved by technology

[0004] Since autologous bone comes from itself, it has good histocompatibility and is not prone to rejection, but its acquisition process may cause complications at the graft donor site, and there is a risk of bone resorption

[0005] The same type of costal cartilage has good biocompatibility, implantation does not cause immune rejection, and can induce tissue regeneration, but the quality of the same type of costal cartilage is easily affected by the age of the donor, and the older donors have a higher degree of calcification , not easy to shape, limited source of material

[0006] Medical silicone is composed of solid silicone rubber material and chemical additives. Solid silicone rhinoplasty material is non-toxic and harmless, and its tissue compatibility is relatively stable. It is the main medical prosthesis nose augmentation material. It is easy to shape during the production process, but silicone After the rubber implant is implanted in the body, it is easy to shift and become transparent, which affects the implant effect

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