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Venom protein gel and preparation method thereof

A technology of snake venom and gel, which is applied in the fields of peptide/protein components, anti-inflammatory agents, pharmaceutical formulas, etc. It can solve the problems of snake venom that have not been seen yet, and achieve the effect of improving drug efficacy and thickening effect

Pending Publication Date: 2019-09-06
NANJING ANGGU PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports of gels containing snake venom

Method used

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  • Venom protein gel and preparation method thereof
  • Venom protein gel and preparation method thereof
  • Venom protein gel and preparation method thereof

Examples

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preparation example Construction

[0038] 1. Preparation of isolated skin

[0039] Male SD rats with a body weight of about (200±20) g were taken, anesthetized with pentobarbital, and executed by neck dislocation. The abdomen of the rats was depilated with scissors, razors, and depilatory cream, and the skin was washed with warm water. Wrap the index finger with gauze, dip it in saline, and gently remove the abdominal fat. The removed skin was rinsed with physiological saline, wrapped in plastic wrap and tin foil, stored in a -20°C refrigerator, and used within three days.

[0040] Transdermal diffusion device and its experiment: use the modified Franz diffusion cell (the upper cell is a cylindrical release cell, and the lower cell is a conical receiving cell), put the two cells together, put the skin in the middle and fix it, the skin penetration area is 2.56 cm -2 , add a small amount of snake venom solution dissolved in ultrapure water on the skin. There is a sampling tube connected to the bottom of the r...

Embodiment 1

[0053] The snake venom gel of this embodiment includes snake venom dry powder, gel matrix, transdermal absorption accelerator, protein protectant, pH regulator, solvent and other pharmaceutically acceptable auxiliary materials;

[0054] The gel matrix is ​​carbomer 940;

[0055] The transdermal absorption accelerator is essential oil;

[0056] The protein protectant is mannitol;

[0057] The pH regulator is a compound of triethanolamine and sodium bicarbonate.

[0058] In terms of mass volume concentration, the concentration of the carbomer 940 is 0.002g / mL;

[0059] In terms of mass volume concentration, the concentration of the triethanolamine is 0.05 g / mL.

[0060] Described essential oil is peppermint oil or turpentine;

[0061] Other pharmaceutically acceptable adjuvants include:

[0062] Moisturizing agent: the moisturizing agent is glycerin;

[0063] Preservative: the preservative is ethylparaben;

[0064] The solvent is distilled water.

[0065] Snake venom gel...

Embodiment 2

[0073] The snake venom gel of this embodiment includes snake venom dry powder, gel matrix, transdermal absorption accelerator, protein protectant, pH regulator, solvent and other pharmaceutically acceptable auxiliary materials;

[0074] The gel matrix is ​​carbomer 940;

[0075] The transdermal absorption accelerator is essential oil;

[0076] The protein protectant is mannitol;

[0077] The pH regulator is a compound of triethanolamine and sodium bicarbonate.

[0078] In terms of mass volume concentration, the concentration of the carbomer 940 is 0.0035g / mL;

[0079] In terms of mass volume concentration, the concentration of the triethanolamine is 0.046g / mL.

[0080] Described essential oil is peppermint oil or turpentine;

[0081] Other pharmaceutically acceptable adjuvants include:

[0082] Moisturizing agent: the moisturizing agent is glycerin;

[0083] Preservative: the preservative is ethylparaben;

[0084] The solvent is distilled water.

[0085] Snake venom ge...

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Abstract

The invention discloses a venom protein gel. The venom protein gel is characterized by comprising venom protein dry powder, a gel matrix, a transdermal absorption promoter, a protein protective agent,a pH regulator, a solvent and other pharmaceutically acceptable auxiliary materials; the gel matrix is carbomer 940; the transdermal absorption promoter is essential oil; the protein protective agentis mannitol; and the pH regulator is a compound of triethanolamine and sodium bicarbonate. The venom protein gel has the characteristic of zero-order drug release.

Description

technical field [0001] The invention relates to a snake venom gel and a preparation method thereof. Background technique [0002] Snake venom is a kind of toxic protein and polypeptide substances secreted by poisonous snakes that contain various enzymes, and it is also a substance that causes poisoning reactions after a poisonous snake bites a person. Fresh snake venom is an egg white-like viscous liquid with a slight fishy smell, which is yellow, light yellow, green, or even colorless. It is neutral or weakly acidic when it is fresh, and it can become alkaline after a long time. The water content is 50%-75%, and the specific gravity is between 1.030-1.080. Fresh venom is easy to produce foam when exposed to air, and it is easy to spoil and deteriorate after being placed at room temperature for 24 hours, losing its toxicity. It can be kept in the refrigerator for 15-30 days, and it can be stored at -40°C for a long time. After vacuum drying or freeze-drying, the snake veno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K9/06A61K47/32A61K47/44A61K47/26A61K47/02A61K47/18A61P29/00
CPCA61K38/1703A61K9/06A61K9/0014A61K47/32A61K47/44A61K47/26A61K47/02A61K47/18A61P29/00
Inventor 程浩
Owner NANJING ANGGU PHARMA TECH
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