Synthesis method of stable isotope labeled pyrethroid

Abstract

The invention discloses a synthesis method of stable isotope labeled pyrethroid. The method includes: taking stable isotope labeled potassium phenate as the labeled precursor for reaction with m-bromobenzaldehyde in inert gas protection under a microwave condition to generate a key intermediate stable isotope labeled m-phenoxybenzaldehyde, then carrying out reaction with substituted chrysanthemoyl chloride under a liquid phase alkaline microwave condition to generate stable isotope labeled pyrethroid. The synthesis method of stable isotope labeled pyrethroid provided by the invention is simple, safe and reliable, after simple separation and purification, the chemical purity of the product can reach 99% or above, and the isotope abundance is 99% or above, the product can be applied to biological metabolism, food safety, inspection and quarantine, environmental monitoring and other fields, and compared with foreign products, the product obtained by the method provided by the invention has the advantages of good quality and low cost.

Description

technical field [0001] The invention relates to a method for synthesizing a stable isotope label, in particular to a method for synthesizing a stable isotope-labeled pyrethroid. Background technique [0002] Pyrethroid pesticides have high efficacy, low toxicity, fast decomposition, less residue, and wide application. They are widely used in crops. However, after application, a considerable part will enter the soil, the atmosphere and remain in crops. Enter the human body along the food chain. Due to the long residual period of certain pyrethroid insecticides, they are not only highly toxic to agricultural beneficial organisms such as bees, silkworms, and butterflies, but also highly toxic to aquatic organisms such as fish, shrimp, crabs, and shellfish. Some pyrethroid pesticides are environmental hormone substances, which also have a great impact on the normal physiological activities of mammals, so long-term exposure even at low doses can cause chronic diseases, and some ...

AI Technical Summary

Problems solved by technology

The synthesis of natural abundance m-phenoxybenzaldehyde mostly adopts the sommlet method, alkali hydrolysis oxidation method, and acid oxidation method (nitric acid and sodium nitrite are oxidation reagents) with m-methoxybenzyl chloride as raw material. The stability of these methods Isotope-labeled m-methoxybenzyl chloride, the raw materials are difficult to obtain, the reaction route is long, and the use of strong acid and strong base is easy to cause abundance dilution, and high vacuum distillation or sodium bisulfite is often used to obtain natural abundance m-phenoxybenzaldehyde Precipitation purification requires expensive and sophisticated equipment or produces a large amount of waste acid, waste alkali, and waste water, and the natural abundance of m-phenoxybenzaldehyde in the crude substrate is also very large, which is obviously not suitable for small quantities, high prices, and abundant Synthesis of isotope-labeled m-phenoxybenzaldehyde with high degree of easy dilution

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