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3D printing composite bio-ink material and preparation method and application thereof

A bio-ink, 3D printing technology, applied in the field of 3D bioprinting, can solve the problems of poor interface bonding between matrix and filler, unfavorable polymer matrix coating, decreased mechanical properties of materials, etc., to improve interface bonding, good application prospects, improve The effect of interface combination

Active Publication Date: 2019-10-08
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the solution 3D printing polylactic acid inks currently reported usually use a volatile single solvent system. Due to the rapid volatilization of the solvent, it is easy to generate pores inside and on the surface of the fiber. These pores become stress concentration points when the material is stressed. , resulting in high brittleness of the material; in addition, due to the rapid deposition and solidification of the polymer matrix, not only the bonding force between adjacent fiber layers is poor, but also it is not conducive to the full coverage of the polymer matrix on the filler surface, which makes the filler agglomeration serious. Poor interfacial bonding between the matrix and the filler, which further leads to a decline in the mechanical properties of the material

Method used

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  • 3D printing composite bio-ink material and preparation method and application thereof
  • 3D printing composite bio-ink material and preparation method and application thereof
  • 3D printing composite bio-ink material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Preparation and 3D printing of ternary solvent composite bio-ink material with added chitin whiskers

[0048] Mix different masses of chitin whiskers (CHW) with 4 mL of dichloromethane, and ultrasonicate for 60 min to form a homogeneous suspension. Add 1 g of poly(L-lactide) (PLLA, Mn=100000) to the above suspension, and magnetically After stirring for 6 hours, 1.3 mL of 2-butoxyethanol and 0.5 mL of dibutyl phthalate were added. After stirring for 4 hours, the air bubbles were removed by ultrasound, and a ternary solvent composite bio-ink material containing CHW was obtained. Then, move it into the syringe and discharge the air bubbles. According to the established digital model, that is, a cylindrical 3D model with a thickness of 10mm and a diameter of 5mm, set the printing speed to 10mm / s and the filling density to 90%, and print it to the receiving platform through the needle at 28°C. Finally, the composite porous scaffold was prepared by layer-by-layer st...

Embodiment 2

[0051] Example 2 Preparation and 3D printing of ternary solvent composite bio-ink material with added hydroxyapatite whiskers

[0052] Different masses of hydroxyapatite whiskers (HAP) were mixed with 3 mL of chloroform, and ultrasonicated for 35 min to form a homogeneous suspension, and 1.2 g of poly(D,L-lactide) (PDLLA, Mn=200000) was added to The above suspension was magnetically stirred for 5 hours, then 1.5 mL of sodium dodecylbenzenesulfonate and 0.5 mL of citrate were added, and after stirring for 10 hours, the air bubbles were removed by ultrasonication at room temperature to obtain a ternary solvent composite bio-ink material with HAP added. Then, move it into the syringe and remove the air bubbles. According to the established digital model, that is, a cylindrical 3D model with a thickness of 5mm and a diameter of 5mm, set the printing speed to 5mm / s and the filling density to 70%, and print it to the receiving platform through the needle at 20°C. Finally, the three-...

Embodiment 3

[0061] Example 3 Preparation and 3D printing of ternary solvent composite bio-ink material with added hydroxyapatite whiskers

[0062] Different masses of hydroxyapatite whiskers (HAP) were mixed with 10 mL of hexafluoroisopropanol, and ultrasonicated for 45 min to form a homogeneous suspension, and 1.0 g of poly(lactide-co-glycolide) (PLGA, Mn =300000) was added to the above suspension, stirred magnetically for 10 hours, then added 1.2mL sodium dodecylbenzenesulfonate and 0.4mL dibutyl phthalate, stirred for 6 hours, and then ultrasonically discharged the air bubbles at room temperature to obtain the HAP-added three Meta-solvent composite bioink materials. Then, move it into the syringe and remove the air bubbles. According to the established digital model, that is, a long 3D model with a length of 5cm, a width of 1cm, and a thickness of 1.5mm, set the printing speed to 25mm / s and the filling density to 45%. The needles were printed on the receiving platform, and finally the...

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Abstract

The invention discloses a 3D printing composite bio-ink material and a preparation method and an application thereof. The components of the composite bio-ink material include biodegradable polyester,a reinforced toughener, and a ternary solvent system. The ternary solvent system contains 40 to 90% of an organic solvent, 5 to 45% of a surfactant, and 5 to 45% of a plasticizer. Compared with a single low-boiling organic solvent system, the ternary solvent system not only improves the printability of the composite bio-ink, but also improves the interface combination between a biodegradable polyester matrix and a reinforcing toughener. Moreover, the interface bonding between fiber layer and the layer during printing is enhanced, and the good three-dimensional structure and mechanical properties of the 3D printing composite porous support can be imparted. In addition, the used reinforcing toughener can further improve the mechanical properties and osteogenic activity of the biodegradable polyester, and imparts excellent bone-promoting ability to repair the composite porous scaffold.

Description

technical field [0001] The invention belongs to the technical field of 3D bioprinting, and in particular relates to a 3D printing composite bioink material and its preparation method and application. Background technique [0002] Bone defects caused by congenital diseases, trauma, tumors and surgery are the most common and frequent clinical diseases, and the treatment of bone defects has always been the main problem faced by reconstructive surgery. There are many technologies reported in the literature for constructing porous scaffolds for bone tissue engineering, but 3D printing, which stands out in recent years, has attracted much attention because of its outstanding advantages. 3D printing is based on the computer three-dimensional design model, using laser guidance, inkjet printing and other technologies to build up and bond biological materials layer by layer, superimpose and shape them, and finally form simulated tissues or organs. 3D printing can flexibly construct s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/12A61L27/20A61L27/56A61L27/54B33Y10/00B33Y70/00B33Y80/00
CPCA61L27/18A61L27/12A61L27/20A61L27/56A61L27/54B33Y10/00B33Y70/00B33Y80/00A61L2300/102A61L2300/112A61L2300/412A61L2420/00C08L67/04C08L5/08
Inventor 罗丙红朱凌刘文军文伟周长忍
Owner JINAN UNIVERSITY
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