Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of preparation method of in-situ cross-linked silver nanowire/polycaprolactone surgical suture thread

A technology of polycaprolactone and silver nanowires, which is applied in the field of surgical sutures, can solve the problems of not being suitable for direct drug administration and affecting the application effect of nano-silver particles, and achieve unique antibacterial mechanism, good dispersion and good antibacterial properties Effect

Active Publication Date: 2021-08-17
南京聚屹新材料有限公司
View PDF17 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, once the silver ion is free, it is easy to absorb human blood through the wound surface of the human body, and while it is excreted in large quantities from the urine through the kidney, it can be deposited in the liver, kidney, cornea, mucosal tissue and wound epithelium of the body, and its particle size is relatively large. Lively in nature, it is easy to agglomerate, forming aggregates with several weak connection surfaces and large size, which affects the actual application effect of nano-silver particles, so it is not suitable for direct drug administration

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method of in-situ cross-linked silver nanowire/polycaprolactone surgical suture thread
  • A kind of preparation method of in-situ cross-linked silver nanowire/polycaprolactone surgical suture thread
  • A kind of preparation method of in-situ cross-linked silver nanowire/polycaprolactone surgical suture thread

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033]

[0034] Preparation of spinning solution: silver nitrate, sodium chloride, ethylene glycol, sodium dodecylbenzenesulfonate, chloroform, polycaprolactone and benzoyl peroxide are completely dissolved by stirring, and configured into a certain The spinning solution with a concentration of 150g / L. After fully stirring the polycaprolactone solution, remove air bubbles under vacuum conditions and place it horizontally.

[0035] Spinning: Add the prepared spinning solution to the wet spinning machine, adjust the temperature of the heating mantle to 60°C to maintain the fluidity of the spinning solution, and adjust the pressure of nitrogen so that the spinning solution can be evenly distributed from the spray Flow out from the silk head, the coagulation bath is methanol, post-treatment after coagulation, that is, heat stretching 2 to 4 times, the temperature of heat stretching is 120°C, and the in-situ method silver nanowire / polycaprolactone spinning is prepared Wire.

...

Embodiment 2

[0038]

[0039]

[0040] Preparation of spinning stock solution: Dissolve silver precursor, precipitant, reducing agent, surfactant and solvent, polycaprolactone completely after stirring, and configure spinning solution with a certain concentration (concentration is 160g / L). After fully stirring the polycaprolactone solution, remove air bubbles under vacuum conditions and place it horizontally.

[0041] Spinning: Add the prepared spinning solution to the wet spinning machine, adjust the temperature of the heating mantle to 80°C to maintain the fluidity of the spinning solution, adjust the pressure of nitrogen, so that the spinning solution can be evenly distributed from the spray Flow out from the silk head, the coagulation bath is methanol, post-treatment after coagulation, that is, heat stretching 4 times, the temperature of heat stretching is 140 ° C, and the in-situ method silver nanowire / polycaprolactone spinning line is prepared.

[0042] Subsequent treatment: Wash ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
tensile strengthaaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of in-situ cross-linked silver nanowire / polycaprolactone surgical suture thread. Firstly, 5-10 parts of silver precursor, 1-2 parts of precipitant, 1-2 parts of Polyhydric alcohol reducing agent, 1-2 parts of surfactant, 50-60 parts of solvent, 100 parts of polycaprolactone and 1-2 parts of initiator are prepared into a spinning solution with a concentration of 150-200g / L. After defoaming, put it into a wet spinning machine with a heating jacket temperature of 60-80°C, adjust the nitrogen pressure so that the spinning solution is evenly sprayed out in a thin stream, and the sprayed stream is coagulated in a methanol coagulation bath, and stretched to 2 ~4 times, then washed in hot water, dried at room temperature, coated with glycerin, dried at room temperature, and finally sterilized and packaged to obtain in-situ cross-linked silver nanowires / polycaprolactone surgical sutures. The polycaprolactone surgical suture thread prepared by the invention can be used in orthopedics, and has high tensile strength and good degradability.

Description

technical field [0001] The patent of the present invention relates to the technical field of surgical sutures, in particular to a preparation method of in-situ cross-linked silver nanowire / polycaprolactone surgical sutures. Background technique [0002] Surgical suture is a sterile thread used for wound closure, tissue ligation and fixation. At present, the common medical sutures on the market mainly include two types: non-absorbable sutures and absorbable sutures. Among them, non-absorbable sutures mainly include natural fibers such as cotton, hemp, and silk, and synthetic polymer materials such as polyester, polyethylene, polypropylene, and polyamide, and also include metal materials such as stainless steel wire, aluminum wire, and silver wire; Absorbable sutures mainly include natural fibers and synthetic polymer materials, such as polyvinyl alcohol (PGA), polycaprolactone (PCL), etc. This type of suture can be absorbed by the body over a period of time, avoiding removal...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/10A61L17/00A61L17/14D01F1/10D01F6/92
CPCA61L17/005A61L17/105A61L17/14A61L2300/104A61L2300/404D01F1/103D01F6/92C08L67/04
Inventor 夏艳平
Owner 南京聚屹新材料有限公司