Pickering high internal phase emulsion, 3D printing porous support material and preparation method of Pickering high internal phase emulsion

A technology of high internal phase emulsion and water phase, applied in the fields of pharmaceutical formula, medical science, prosthesis, etc., can solve the problems of long dialysis time period, acrylamide toxicity, high production cost, etc., and achieve good biocompatibility and biological activity , pore diameter and pore throat size reduction, and the effect of enhanced mechanical properties
CN110396205AActive Publication Date: 2019-11-01SOUTH CHINA AGRI UNIV +1
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTH CHINA AGRI UNIV
Publication Date
2019-11-01

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Abstract

The invention relates to a Pickering high internal phase emulsion, a 3D printing porous support material prepared from the Pickering high internal phase emulsion and a preparation method of the Pickering high internal phase emulsion. The method comprises the following steps: nano-hydroxyapatite particles are used as an emulsion stabilizer, gelatin, collagen and genipin are dissolved into deionizedwater to form a continuous phase of an emulsion, an organic solvent is used as a dispersion phase, emulsification treatment is performed, a cross-linking reaction is performed to form the oil-in-water Pickering high internal phase emulsion, the continuous phase of the emulsion is fixed, finally 3D printing is performed to obtain a gel support, the solvent is volatilized to remove the dispersion phase, and drying is performed to obtain the porous support material with communicating pores and adjustable pore diameters. According to the method provided by the invention, an emulsion template method is adopted, the emulsion template method is combined with a 3D printing technology, so that the prepared porous support material has the advantages of high porosity, communicating pores, adjustablepore diameters, good biocompatibility, no toxicity or harm to organisms and the like, and has a wide application prospect in the field of biomedical materials.
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Description

technical field

[0001] The invention belongs to the field of biomedical materials, and in particular relates to a Pickering high internal phase emulsion, a 3D printing porous scaffold material prepared by using the same, and a preparation method. Background technique

[0002] Porous scaffold material is a material with a three-dimensional network structure, which contains a large number of voids, and has unique characteristics such as large specific surface area, low density, and high porosity. field has a very wide range of applications. Therefore, it is very necessary to construct a porous scaffold material suitable for tissue repair. An ideal porous scaffold material for tissue repair should have the following characteristics: good mechanical properties to withstand environmental stress, non-toxicity to cells, good biocompatibility, drug loading, sustained release, and high porosity to secure cellular nutrients and transport of metabolic waste.

[0003] At present, the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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