Clindamycin metronidazole liniment and preparation process thereof

A technology of metronidazole liniment and clindamycin, applied in the direction of anti-inflammatory agent, aerosol delivery, local antibacterial agent, etc., can solve single, at most 1-2, many adverse reactions, skin Dryness and other problems, to achieve the effect of regulating the function of sebaceous glands, reducing dry skin, and the finished product is even and delicate

Inactive Publication Date: 2019-11-26
江苏晨牌邦德药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the existing acne treatment drugs are unilateral, and the effect is relatively single. For example, the drugs mainly for inflammatory acne are mostly antibiotics, including metronidazole, erythromycin, clindamycin, and chloramphenicol, which mainly play an antibacterial role. It also has anti-inflammatory effects; the drugs mainly for non-inflammatory acne include retinoic acid, benzoyl peroxide, salicylic acid, lactic acid, etc.
The main problem of unilateral therapy is that on the one hand, it has a single effect, and it can only target 1-2 pathogenic links at most (such as antibacterial plus anti-inflammatory, or antibacterial plus anti-angular tie); on the other hand, some oral preparations have many adverse reactions, even some External preparations, due to the side effects of the drug itself, can cause allergic reactions such as dry skin, local irritation, and rashes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] First, keep the ingredient pot at 65ºC. Add 16% ethanol and 11% glycerin in the batching pot, start stirring, slowly and evenly sprinkle 2% transdermal absorbent propylene glycol, antioxidant, metal ion chelating agent and mix evenly; then add metronidazole 8 %, tazarotene 4%, ethylparaben 0.1%, circulate and stir for 20min.

[0017] Then, add an appropriate amount of purified water into the stainless steel container, add 8% clindamycin hydrochloride into the purified water, stir with a stainless steel stirring rod until dissolved, and add it to the batching pot.

[0018] Finally, add 7% white petrolatum and purified water to the full amount in the batching pot, and circulate and stir for 30 minutes.

Embodiment 2

[0020] First, add 20% ethanol and 18% glycerin to the batching pot, start stirring, slowly and evenly sprinkle 3.5% by weight of transdermal absorbent propylene glycol, antioxidant, metal ion chelating agent and mix evenly; then add metronidrone azole 20%, tazarotene 3%, ethylparaben 0.1%, and circulated for 25 minutes.

[0021] Then, add an appropriate amount of purified water into the stainless steel vessel, add 10% clindamycin hydrochloride into the purified water, stir with a stainless steel stirring rod until dissolved, and add it to the batching pot.

[0022] Finally, add 7% white petrolatum and purified water to the full amount in the batching pot, and circulate and stir for 32 minutes. The ingredient pot temperature was maintained at 65ºC.

Embodiment 3

[0024] First, add 24% ethanol and 12% glycerin to the batching pot, start stirring, slowly and evenly sprinkle 4% by weight transdermal absorbent propylene glycol, antioxidant, metal ion chelating agent and mix evenly; then add metronidrone azole 8%, tazarotene 5%, ethylparaben 0.03%, and circulated and stirred for 30 minutes.

[0025] Then, add an appropriate amount of purified water into the stainless steel container, add 7% clindamycin hydrochloride into the purified water, stir with a stainless steel stirring rod until dissolved, and add it to the batching pot.

[0026] Finally, add 4% white petrolatum and purified water to the full amount in the batching pot, and circulate and stir for 35 minutes. The ingredient pot temperature was maintained at 65ºC.

[0027] preparation:

[0028] First put the ethanol and glycerin of the above-mentioned embodiment 1, embodiment 2 or embodiment 3 into the batching pot according to the formula, start stirring, and slowly and evenly spri...

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PUM

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Abstract

The invention relates to a clindamycin metronidazole liniment. The liniment specifically includes the following ingredients in percentage by weight: 16-24% of ethanol, 12-18% of glycerin, 15-30% of clindamycin hydrochloride or metronidazole, 3-5% of tazarotene, 3-7% of white vaseline, 0.02-0.1% of ethylparaben, and the balance of purified water. A preparation process of the liniment includes the following steps: firstly adding the ethanol and the glycerin into a stirring blending pot, uniformly sprinkling 2-4% of a transdermal absorbent, and then adding the metronidazole, the tazarotene and the ethylparaben; stirring the clindamycin hydrochloride in a stainless steel vessel until the clindamycin hydrochloride dissolves, and adding the dissolved clindamycin hydrochloride to the blending pot; and finally, adding the white vaseline and the purified water to reach the full amount, and performing stirring for 30 to 35 minutes to form the liniment. The liniment is novel in drug composition,has no irritation to the skin, and reduces the side effects such as dryness, desquamation and erythema. The production process of the invention is simple. The finished product is uniform and delicate,has high curative effect, and is easy to wash after external use.

Description

technical field [0001] The invention relates to a clindamycin metronidazole liniment and a preparation process thereof. Background technique [0002] Clindamycin metronidazole liniment is used for acne vulgaris, and can also be used for seborrheic dermatitis, rosacea, and folliculitis. Acne is a chronic disease of the sebaceous glands and the second most common disease in dermatology. The clinical manifestations are characterized by pleomorphic skin lesions such as acne, papules, pustules, and nodules that occur on the face. The incidence rate accounts for 7-10% of skin diseases. The age of the disease covers 11-30 years old, and both men and women can suffer from it. . [0003] The current clinical treatment of acne mainly relies on drug therapy, targeting at the onset of acne, mainly antibacterial and anti-inflammatory for inflammatory acne; mainly dissolving comedones for non-inflammatory acne. Most of the existing acne treatment drugs are unilateral, and the effect is...

Claims

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Application Information

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IPC IPC(8): A61K31/7056A61K31/455A61K9/06A61K47/06A61K47/10A61P17/00A61P29/00A61P31/02A61P17/10A61K31/4164
CPCA61K9/06A61K31/4164A61K31/455A61K31/7056A61K47/06A61K47/10A61P17/00A61P17/10A61P29/00A61P31/02A61K2300/00
Inventor 庄永辉
Owner 江苏晨牌邦德药业有限公司
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