Cefuroxime axetil granule and preparation method thereof

A technology of cefuroxime axetil and granules, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as agglomeration, bitter aftertaste of preparations, poor dispersion, etc.
CN110664779APending Publication Date: 2020-01-10SHANDONG LUKANG PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANDONG LUKANG PHARMA
Publication Date
2020-01-10

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Abstract

The invention provides a cefuroxime axetil granule and a preparation method thereof, and belongs to the field of medicine preparations. A fluidized bed granulation and coating technology is adopted tocarry out fluidized bed granulation and coating on cefuroxime axetil. Since the cefuroxime axetil is unstable when the cefuroxime axetil is under a hot and humid condition, a fluidized bed granulation and coating way adhesive solution volatilizes while the solution is sprayed, direct contact between the cefuroxime axetil and water is effectively avoided, the prepared granules are even, and product quality is stable. In addition, a pore-foaming agent and a methacrylic acid-acrylic acid ethyl ester copolymer at a specific ratio are added into taste-masking coating ingredients to guarantee the releasing of the cefuroxime axetil while granules are accelerated to carry out taste masking. The cefuroxime axetil granule provided by the invention can effectively cover the bitter taste of the cefuroxime axetil, meanwhile, the preparation can be guaranteed to favorably disperse in water, and therefore, the cefuroxime axetil granule is especially suitable for children and people who suffer from dysphagia.
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Description

technical field

[0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a cefuroxime axetil granule and a preparation method thereof. Background technique

[0002] Cefuroxime axetil (cefuroxime axetil) is an oral cephalosporin antibiotic, which has the advantages of broad antibacterial spectrum and strong antibacterial activity. Its molecular formula is C 20 h 22 N 4 o 10 S, with a relative molecular weight of 510.47, is a white to yellow-white amorphous powder, easily soluble in dimethyl sulfoxide, slightly soluble in methanol, slightly soluble in ethanol, very insoluble in water. Its structural formula is as follows:

[0003]

[0004] Cefuroxime axetil is a prodrug of the second-generation cephalosporin cefuroxime. Cefuroxime axetil itself does not have antibacterial activity. After oral absorption, it is rapidly hydrolyzed by non-specific enzymes in body fluids and blood to generate cefuroxime to exert antibacterial eff...

Claims

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