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Gain material self-aggregation laser and preparation method thereof

A laser and self-aggregation technology, applied in the laser field, can solve problems such as long response time, high detection limit, and reduced optical quality, and achieve the effects of improving imaging contrast, high targeting binding force, and strong penetrating ability

Active Publication Date: 2020-01-10
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult for larger-sized micro lasers (on the order of microns) to penetrate the cell membrane, and it is not easy to realize real-time detection in cells
At the same time, reducing the size of the micro-laser will cause defects such as increased laser threshold and reduced optical quality.
Moreover, in the trace detection in vivo, the analyte diffuses into the optical resonant cavity by diffusion, and combines with molecules with targeted binding ability to realize the detection. This process has the disadvantages of slow diffusion speed, long response time, and high detection limit. , can not really achieve ultra-low detection limit, high sensitivity, fast response chemical and biological detection

Method used

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  • Gain material self-aggregation laser and preparation method thereof
  • Gain material self-aggregation laser and preparation method thereof
  • Gain material self-aggregation laser and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] This embodiment provides a near-infrared emission gain material self-concentrating laser, the preparation of which includes the following steps:

[0038](1) Dip epoxy resin with a 125 μm optical fiber and apply it on the surface of a transparent quartz groove with a low refractive index. The refractive index of the quartz groove is 1.47. The epoxy resin is distributed in strips on the quartz surface with a width of about 100 μm. The height of the quartz groove is 125 μm, and the upper part of the groove is covered with a glass sheet.

[0039] (2) Add surfactant PEG and gain material CNDPA to the mixed solvent of water and DMF (volume ratio 1:1), the concentrations are 1mg / mL and 0.1mg / mL, respectively. Under the action of the interfacial tension of the mixed solvent, the epoxy resin self-assembles into a spherical shape after 24s. The diameter of the microsphere is 30 μm, and the diameter of the microsphere can be adjusted by the fiber diameter. The optical photos of t...

Embodiment 2

[0043] This embodiment provides a self-concentrating laser of a gain material that emits green light, and its preparation includes the following steps:

[0044] (1) Use a 300 μm optical fiber to dip liquid phenolic resin and apply it on the surface of a transparent magnesium fluoride groove with a low refractive index. The refractive index of magnesium fluoride is 1.38. The epoxy resin is distributed in strips on the quartz surface with a width of about 250 μm. The height of the magnesium fluoride groove is 300 μm, and the upper part of the groove is covered with a glass sheet.

[0045] (2) The surfactant CTAB and the gain material TPE-BODIPY were added to the mixed solvent of water and THF (volume ratio 2:1), with concentrations of 10 mg / mL and 1 mg / mL, respectively. Under the action of the interfacial tension of the mixed solvent, the liquid phenolic resin self-assembles into a spherical shape, and the diameter of the microsphere is 150 μm, which can be adjusted by the diame...

Embodiment 3

[0049] This embodiment provides a gain material self-concentrating laser, the preparation of which includes the following steps:

[0050] (1) Use a 25μm optical fiber to dip liquid linear unsaturated polyester resin and apply it on the surface of a transparent calcium fluoride groove with a low refractive index. The refractive index of calcium fluoride is 1.434. The epoxy resin is distributed in strips on the quartz surface, with a width of About 25 μm. The height of the magnesium fluoride groove is 50 μm, and the upper part of the groove is covered with a glass sheet.

[0051] (2) The surfactant CTAB and the gain material TPE-BODIPY were added to the mixed solvent of water and DMF (volume ratio 3:1), the concentrations were 0.1mg / mL and 0.001mg / mL, respectively. Under the action of the interfacial tension of the mixed solvent, the polyester resin self-assembles into spheres with a diameter of 5 μm, which can be adjusted by the diameter of the optical fiber.

[0052] (3) The...

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Abstract

The invention discloses a gain material self-aggregation laser and a preparation method thereof. The laser is a polymer microsphere which stably exists in a solution and contains a gain material, a surfactant is distributed on the surface of the microsphere, the concentration of the gain material in the polymer microsphere is higher than the concentration of the gain material in the solution outside the polymer microsphere, the gain material does not emit light in the solution, and laser is realized in the polymer microsphere. The gain material of the self-aggregation laser is in a small molecular state before aggregation, has the advantages of small size, strong penetrability and strong targeting binding force, and can smoothly penetrate through interfaces such as cell membranes, porous films, molecular sieves and the like; and after aggregation, a high-performance optical resonant cavity is self-assembled, and laser output is realized under the excitation of pump light. The gain material for laser aggregation does not emit light before aggregation and emits light efficiently after aggregation, the signal-to-noise ratio in imaging application can be further improved, and the imaging contrast ratio is greatly improved.

Description

technical field [0001] The invention relates to the field of laser technology, in particular to a gain material self-gathering laser and a preparation method thereof. Background technique [0002] Due to the advantages of flexibility and easy processing, high absorption and emission cross section, rich energy level regulation, and good biocompatibility, organic microlasers have important applications in the fields of biological cell environment detection, chemical sensing, and cell tracking. Microlasers with narrow linewidth and high Q are very sensitive to environmental changes, thus enabling trace molecular detection. For example, literature 1 (He L, Özdemir S K, Zhu J, et al. Detecting single viruses and nanoparticles using whispering gallery microlasers[J]. Nature nanotechnology, 2011, 6(7): 428.) uses narrow linewidth microlasers in Mode cleavage occurs under the disturbance of environmental molecules to detect a single influenza virus, achieving ultra-high sensitivity...

Claims

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Application Information

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IPC IPC(8): H01S3/20
CPCH01S3/20
Inventor 杨中民刘旺旺虞华康
Owner SOUTH CHINA UNIV OF TECH