Antibacterial polyamino acid derivatives or copolymers having alternating structures and preparation method of antibacterial polyamino acid derivatives or copolymers

Abstract

The invention discloses antibacterial polyamino acid derivatives or copolymers having alternating structures and a preparation method of the antibacterial polyamino acid derivatives or copolymers. Thepolyamino acid derivatives or copolymers have alternating structural units and a same conformation, in the alternating repeating structural units, one is a basic amino acid or a derivative of the basic amino acid, and the polyamino antibacterial materials with different hydrophobicity, material strength, degradation rates and antibacterial activity are obtained by changing the type of another amino acid. At the same time, small molecule fragments obtained by degradation of the polyamino acid derivatives or copolymers synthesized by the method have a same conformation, still have alternating structural repeat units, and are finally degraded by human bodies to obtain small amino acid molecules, and the structural feature guarantees the biocompatibility and degradability of the materials andthe structural clarity and controllability, and is conducive to exploring biological activity and antibacterial mechanisms.

Description

technical field [0001] The invention relates to the field of antibacterial materials. More specifically, it relates to an alternating structure antibacterial polyamino acid derivative or copolymer and a preparation method thereof. Background technique [0002] With the continuous improvement of people's health awareness and medical and health level, people's demand and requirements for antibacterial materials are also increasing. In addition to antibacterial properties, antibacterial materials often require high biological safety and environmental safety, such as antibacterial materials. Medical devices not only need to effectively inhibit the growth and reproduction of bacteria, but also need good safety. At present, most antibacterial materials are mainly materials that can release antibacterial metal ions and antibacterial materials of quaternary ammonium salts. These materials all have strong antibacterial properties, but due to the disadvantages of certain cytotoxicit...

AI Technical Summary

Problems solved by technology

At present, most polyamino acids are obtained by anionic polymerization to obtain block copolymers composed of two or more amino acid repeating units. The polyamino acid copolymers obtained by this method have different amino acids in different segments on any main chain. The sequence of repeating units, by adding different amino acids, the structure of the polyamino acid copolymer cannot be precisely adjusted, and the properties of the polymer such as hydrophilicity and hydrophobicity, material strength, degradation rate, antibacterial activity, and biological safety cannot be effectively controlled.

When the polyamino acid copolymer obtained by this type of method is degraded in vivo or in vitro, the structures of the degraded fragments are different, and the exploration of its antibacterial mechanism cannot be carried out.

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