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Seminal plasma biochemical quality control product and preparation method thereof

A technology of quality control products and seminal pulp, applied in the preparation of test samples, biological testing, material inspection products, etc., can solve the problems of limited raw material sources, hidden dangers of biological safety, unfavorable long-distance transportation of retained samples for testing, and overcome the problems of raw material limited source effects

Active Publication Date: 2020-03-06
珠海高瑞特医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned quality control products use human seminal plasma as the matrix, which has the disadvantages of limited raw material sources, potential biological safety hazards, and poor stability. At the same time, the storage time of this seminal plasma quality control product is short, which is not conducive to the detection of reserved samples and long-distance transportation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A seminal plasma biochemical quality control product, including artificial seminal plasma matrix liquid, quality control item additives, stabilizers, freeze-drying protective agents and preservatives, which are made into freeze-dried powder after mixing several substances;

[0034] Wherein, the artificial seminal plasma matrix fluid includes human albumin, human γ-globulin, vitamin C, bovine fibrinogen, thrombin, plasmin, calcium chloride and PBS buffer;

[0035] The added substances of the quality control items are α-glucosidase, fructose, zinc, acid phosphatase, lactate dehydrogenase-X isoenzyme, acrosome, citric acid, superoxide gasase, elastic protease, carnitine, glutamyl transpeptidase; the stabilizer is PEG400 and mannitol; the lyoprotectant is trehalose and glycine; preservative: sodium azide.

[0036] Wherein, each liter of the artificial seminal plasma matrix liquid contains human albumin 5g / L, human γ-globulin 15g / L, vitamin C 20μmmol / L, bovine fibrinogen 5mg...

Embodiment 2

[0044] A seminal plasma biochemical quality control product, including artificial seminal plasma matrix liquid, quality control item additives, stabilizers, freeze-drying protective agents and preservatives, which are made into freeze-dried powder after mixing several substances;

[0045] Wherein, the artificial seminal plasma matrix fluid includes human albumin, human γ-globulin, vitamin C, bovine fibrinogen, thrombin, plasmin, calcium chloride and PBS buffer;

[0046] The added substances of the quality control items are α-glucosidase, fructose, zinc, acid phosphatase, lactate dehydrogenase-X isoenzyme, acrosome, citric acid, superoxide gasase, elastic Protease, carnitine, glutamyl transpeptidase; the stabilizer is PEG400 and mannitol; the freeze-drying protectant is trehalose and glycine; the preservative is sodium azide.

[0047] Wherein, each liter of the artificial seminal plasma matrix liquid contains human albumin 10g / L, human γ-globulin 30g / L, vitamin C 40μmmol / L, bov...

Embodiment 3

[0054] A seminal plasma biochemical quality control product, including artificial seminal plasma matrix liquid, quality control item additives, stabilizers, freeze-drying protective agents and preservatives, which are made into freeze-dried powder after mixing several substances;

[0055] Wherein, the artificial seminal plasma matrix fluid includes human albumin, human γ-globulin, vitamin C, bovine fibrinogen, thrombin, plasmin, calcium chloride and PBS buffer;

[0056] The added substances of the quality control items are α-glucosidase, fructose, zinc, acid phosphatase, lactate dehydrogenase-X isoenzyme, acrosome, citric acid, superoxide gasase, elastic protease, carnitine, glutamyl transpeptidase; the stabilizer is PEG400 and mannitol; the lyoprotectant is trehalose and glycine; preservative: sodium azide.

[0057] Wherein, each liter of the artificial seminal plasma matrix liquid contains human albumin 15g / L, human γ-globulin 50g / L, vitamin C 50μmmol / L, bovine fibrinogen 40...

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PUM

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Abstract

The invention discloses a seminal plasma biochemical quality control product. The seminal plasma biochemical quality control product comprises artificial seminal plasma matrix solution, quality control project added substances, stabilizers, freeze-drying protectants and a preservative, which are mixed to prepare freeze-dried powder, wherein the artificial seminal plasma matrix solution comprises human albumin, human gamma-globulin, vitamin C, bovine fibrinogen, thrombin, plasmin, calcium chloride and PBS buffer solution; the quality control project added substances comprise alpha-glucosaccharase, fructose, zinc, acid phosphatase, lactic dehydrogenase-X isoenzyme, acrosin, citric acid, superoxide gasification enzyme, elastinase, carnitine and glutamyltranspeptidase; the stabilizers comprisePEG400 and mannitol; the freeze-drying protectants comprise trehalose and glycine; and the preservative is sodium azide.

Description

technical field [0001] The invention belongs to the technical field of in vitro detection reagents, and relates to a seminal plasma biochemical quality control product and a preparation method thereof. Background technique [0002] There has been a lack of experimental quality control materials for the detection of biochemical indicators in semen, which makes the standardization of semen biochemical analysis stagnant. Many substances in semen are unstable in vitro and difficult to preserve, which increases the technical difficulty of preparing seminal plasma quality control products. In order to solve the problem of semen quality control products, the patent application number CN201410145716.0 provides a seminal plasma composite quality control product with seminal plasma as the substrate. In this application, the seminal plasma composite quality control product consists of quality control product preservation solution The freeze-dried powder made by mixing with the seminal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28G01N33/48G01N33/50
CPCG01N1/28G01N33/50G01N33/48
Inventor 张道兵
Owner 珠海高瑞特医疗科技有限公司
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