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A kind of nano material and its preparation method and application

A nanomaterial and nanoparticle technology, applied in the field of nanomaterials, can solve problems such as uncontrolled, high cytotoxicity, and many side reactions of synthesis, and achieve the effect of great application potential and high biological photosensitivity

Active Publication Date: 2021-06-15
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Amino or carboxyl modification on the surface of nanomaterials can also greatly increase the solubility of nanomaterials in aqueous solution, but amino surface ligands usually bring high cytotoxicity, while carboxyl surface modified nanoparticles have fluorescent quantum The disadvantages of low yield, many side reactions and uncontrolled synthesis

Method used

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  • A kind of nano material and its preparation method and application
  • A kind of nano material and its preparation method and application
  • A kind of nano material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: Preparation of nanoparticles with amine covalent linkage activity on the surface

[0036] (1) Preparation of silicon nanoparticles CHO-Si (nanoparticle II) with aldehyde group modification on the surface: Mix trimethoxysilane (4mL), methanol (5mL), water (5mL) and nitric acid (50mmol) and stir for 2 minutes , when the system appears gel or even completely solidified, stop stirring. After the reactant was aged for two days, the reactant was dried under vacuum for 24 hours and then taken out. The completely dried silanol-rich xerogel was placed in a tube furnace, and heated at 1100° C. for 1 hour under a mixed atmosphere of hydrogen and argon. After cooling, it is pre-ground with an agate mortar, and then added to a ball mill for ball milling. The obtained pale yellow powder was dispersed in a mixed etching solution of water, ethanol and hydrofluoric acid. After the etching reaction was carried out for one hour, the hydrogen-bonded surface-modified nanoparti...

Embodiment 2

[0040] Example 2: Preparation of nanoparticles IV with imine bonds covalently attached to the surface

[0041] The silicon nanoparticle CHO-Si (nanoparticle II) modified by the aldehyde functional group prepared in Example 1 is well dispersed in the solvent chloroform by ultrasonic, and moved into a pressure-resistant tube equipped with a polytetrafluoroethylene stopper, and added with 0.2 mol of butylamine in the active primary amino group is heated and reacted at 85-120° C. for 24-36 hours. The red fluorescence of the system gradually faded, showing purple-red fluorescence, and finally blue fluorescence at the end of the reaction. Centrifuge the whole system, take the supernatant and spin dry to remove the solvent, then re-disperse the nanoparticles in ultrapure water, and then obtain the nanoparticles IV with imine bonds covalently connected on the surface, the transmission electron microscope picture is as follows image 3 As shown (the black part in the lower left corner...

Embodiment 3

[0042] Example 3: Preparation of nanoparticles V with amide bond covalent linking activity on the surface

[0043] The silicon nanoparticle COOH-Si (nanoparticle III) modified by the carboxyl functional group prepared in Example 1 is well ultrasonically dispersed in the solvent acetonitrile, and moved into a pressure-resistant tube equipped with a polytetrafluoroethylene stopper, adding phenylethylamine 0.2mol, heat reaction between 25~120℃ for 24~48h. The red fluorescence of the system gradually faded, showing purple-red fluorescence, and finally blue fluorescence at the end of the reaction. The whole system was subjected to centrifugation, the supernatant was obtained by rotary evaporation and dried to remove the solvent, and then the nanoparticles were re-dispersed in ultrapure water to obtain nanoparticles V with amide bonds covalently connected on the surface.

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Abstract

The invention discloses a nanometer material and its preparation method and application. The method realizes the controllable preparation of nanoparticles with special surface modification by precisely controlling the progress of nanoparticle surface reactions and ligand modification at the nanometer scale, and can finely regulate and optimize the physical and chemical properties of the nanomaterials. The nanomaterial has good biocompatibility and non-toxicity, and is highly dispersible in aqueous solution. It has broad application prospects in many fields such as drug development, targeted therapy, biosensing, and in vivo imaging. The biophotosensitivity of the biosensitivity, which can rapidly blue-shift the fluorescence after interacting with biomolecules or cells, has great application potential in the field of biosensing.

Description

technical field [0001] The invention relates to the field of nanomaterials, in particular to a nanomaterial and its preparation method and application. Background technique [0002] Due to their special biological non-toxicity and biocompatibility, semiconductor nanomaterials have great application prospects in many fields such as biomedicine, targeted therapy, biosensing, and in vivo imaging. After the first application of semiconductor nanocrystals as fluorescent probes in biological imaging, other biological applications such as DNA chip technology, immunofluorescence assays, and cell biozoology have also begun to widely use semiconductor nanocrystals. As a new fluorescent material with great potential without isotope labeling, semiconductor nanocrystals have won wide recognition in the scientific and bioindustry circles. The properties of interest for biological applications are high brightness, photostability, and tunability of fluorescence emission. For two-photon co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64C09K11/02B82Y20/00B82Y30/00B82Y40/00
CPCB82Y20/00B82Y30/00B82Y40/00C09K11/025G01N21/6428G01N21/6486G01N2021/6439
Inventor 杨振宇陈槐
Owner SUN YAT SEN UNIV
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