Anhydrous calcium hydrophosphate/hydroxyapatite biphasic porous microsphere material, and preparation method and application thereof

An anhydrous calcium hydrogen phosphate, hydroxyapatite technology, applied in chemical instruments and methods, inorganic chemistry, phosphorus compounds, etc., can solve the problem of poor process repeatability and product morphology stability, low adjustable temperature range, and reaction time. It can improve the biomineralization ability, good degradability, and promote cell proliferation.

Active Publication Date: 2020-03-17
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] According to the principle of hydrolysis reaction, the method of preparing DCPA / HAP dual-phase ceramics is mainly the homogeneous precipitation method. The homogeneous precipitation method synthesizes mostly dual-phase whiskers and whiskers assembled into "strings" instead of microspheres. The adjustable temperature range of the phase precipitation method is low and the reaction time is too long, resulting in poor process repeatability and product shape stability

Method used

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  • Anhydrous calcium hydrophosphate/hydroxyapatite biphasic porous microsphere material, and preparation method and application thereof
  • Anhydrous calcium hydrophosphate/hydroxyapatite biphasic porous microsphere material, and preparation method and application thereof
  • Anhydrous calcium hydrophosphate/hydroxyapatite biphasic porous microsphere material, and preparation method and application thereof

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Embodiment 1

[0036] An anhydrous calcium hydrogen phosphate / hydroxyapatite dual-phase porous microsphere material, the specific preparation steps are as follows:

[0037] (1) Prepare a mixed solution of calcium salt, phosphorus salt, sedimentation agent and nucleating agent; the calcium salt used is calcium nitrate and calcium chloride mixed at a mass ratio of 1:1, and the concentration of calcium salt in the mixed solution is 0.05mol / L; Phosphate salt is a mixture of potassium dihydrogen phosphate and sodium dihydrogen phosphate at a mass ratio of 1:1, and the concentration of phosphorus salt in the mixture is 0.03mol / L; the precipitant is concentrated ammonia water with a mass fraction of 25-28%. The concentration of ammonia in the liquid is 0.2mol / L;

[0038] (2) Select concentrated nitric acid with a mass fraction of 86-97.5% to adjust the pH value of the mixture in step (1) to 2.5;

[0039] (3) Put the mixed liquid in step (2) into the reactor, the mixed liquid accounts for 70% of t...

Embodiment 2

[0044] An anhydrous calcium hydrogen phosphate / hydroxyapatite dual-phase porous microsphere material, the specific preparation steps are as follows:

[0045] (1) Configure a mixed solution of calcium salt, phosphorus salt, sedimentation agent and nucleating agent; the calcium salt used is calcium nitrate, and the concentration of calcium salt in the mixed solution is 0.167mol / L; the phosphorus salt is diammonium hydrogen phosphate, The concentration of phosphorus salt in the mixed solution is 0.1mol / L; the precipitating agent is urea, the concentration of urea in the mixed solution is 0.7mol / L, the nucleating agent is strontium nitrate, and the addition amount is 20% of the molar amount of calcium salt;

[0046] (2) Select concentrated ammonia water with a mass fraction of 25-28% to adjust the pH value of the mixture in step (1) to 3;

[0047] (3) Put the mixed liquid in step (2) into the reactor, the mixed liquid accounts for 40% of the effective volume of the reactor, and ca...

Embodiment 3

[0052] An anhydrous calcium hydrogen phosphate / hydroxyapatite dual-phase porous microsphere material, the specific preparation steps are as follows:

[0053] (1) Prepare a mixed solution of calcium salt, phosphorus salt, sedimentation agent and nucleating agent; the calcium salt used is a mixture of calcium hydroxide and calcium hydrogen phosphate at a mass ratio of 1:1, and the concentration of calcium salt in the mixed solution is 2mol / L; Phosphorus salt is a mixture of phosphoric acid and ammonium phosphate at a mass ratio of 1:1, and the concentration of phosphorus salt in the mixed solution is 1.25mol / L; the precipitating agent is urea, and the concentration of urea in the mixed solution is 2.5mol / L, and the nucleating agent is Magnesium chloride and strontium chloride are added in an amount of 0.01% and 0.03% of the molar amount of the calcium salt, respectively;

[0054] (2) Select concentrated nitric acid with a mass fraction of 86-97.5% to adjust the pH value of the ...

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Abstract

The invention discloses an anhydrous calcium hydrophosphate/hydroxyapatite biphasic porous microsphere material, and a preparation method and an application thereof. The anhydrous calcium hydrophosphate/hydroxyapatite biphasic porous microsphere material is particle microspheres formed by coexistence of 10%-90% by mass of anhydrous calcium hydrophosphate and 90%-10% by mass of hydroxyapatite, theparticle diameter is 15-65 [mu]m, the surface is porous, the pore size range is 1-50 [mu]m, and the porosity is 33%-65.34%, and the anhydrous calcium hydrophosphate/hydroxyapatite biphasic porous microsphere material is prepared by a hydrothermal precipitation method; the anhydrous calcium hydrophosphate/hydroxyapatite biphasic porous microsphere material disclosed by the invention has relativelygood biocompatibility and biomineralization capability, relatively short degradation period, and high pore size and porosity, is an ideal biomedical material, and can be used for constructing bone tissue engineering scaffolds or used as a sustained-release carrier of antibiotics, antituberculous compounds, growth factors, antitumor agents and the like.

Description

technical field [0001] The invention relates to a surface with good biocompatibility and biomineralization ability, relatively high pore size and porosity, formed by the coexistence of anhydrous calcium hydrogen phosphate (DCPA) and hydroxyapatite (HAP) The spherical microsphere material with a porous structure and its preparation method and application, the dual-phase porous microsphere prepared by the present invention can be widely used as raw materials for preparing bone tissue engineering scaffolds, or as antibiotics, anti-tuberculosis compounds, growth factors, antibacterial The invention relates to a sustained-release carrier for tumor agents and the like, belonging to the field of biomaterials. Background technique [0002] A typical material in biomedical ceramics is hydroxyapatite (HAP), whose chemical formula is Ca10(PO4) 6 (OH) 2 , belongs to the hexagonal system, space group P63 / m. Because its composition is close to the inorganic matter in human bone, it sho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32A61L27/42A61L27/56A61K9/16A61K47/02
CPCC01B25/32A61L27/425A61L27/56A61K9/1611C01P2004/61C01P2004/32C01P2002/72C01P2004/03C01P2002/82
Inventor 刘金坤钏定泽陈庆华冷崇燕
Owner KUNMING UNIV OF SCI & TECH
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