Ultrahigh-partition-coefficient composite iodine solution and preparation method thereof

A technology of distribution coefficient and iodine solution, which is applied in botany equipment and methods, chemicals for biological control, animal repellants, etc., can solve the problems of low iodine complexation degree and low distribution coefficient, and achieve water solubility Good, high safety, enhanced storage stability

Inactive Publication Date: 2020-05-08
河北华邦生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

If the degree of iodine complexation is low, the partition coefficient will be low, which may be lower than 130 or even a negative number. At t

Method used

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  • Ultrahigh-partition-coefficient composite iodine solution and preparation method thereof
  • Ultrahigh-partition-coefficient composite iodine solution and preparation method thereof
  • Ultrahigh-partition-coefficient composite iodine solution and preparation method thereof

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preparation example Construction

[0039] The present invention also provides a method for preparing an ultra-high partition coefficient composite iodine solution, the method comprising: dissolving the nonionic surfactant in hydrochloric acid, stirring at room temperature for 2-12h, and then adding iodine and iodide or Iodine salt, continue to stir for 6-8h to obtain iodine / nonionic surfactant complex solution, then add phosphoric acid and purified water to the complex solution, continue to stir for 30-60min, obtain reddish-brown viscous liquid, which is compound iodine solution. This method complexes iodine and iodide ions on the surfactant, which overcomes the disadvantages of iodine being insoluble in water, unstable, and highly irritating. The resulting compound iodine solution can effectively kill most of the bacterial propagules, spores, and viruses , fungi, protozoa, phage and other pathogenic microorganisms have a wide range of adaptation to the pH value of water and have strong bactericidal and virus-k...

Embodiment 1

[0042] A kind of preparation method of nonionic surfactant, its concrete steps are as follows:

[0043] (1) Place pimelic acid and dodecane oxide in 4 times the amount of toluene after mixing, then add 1.5wt% chromium acetate and 25wt% concentration of 60% potassium hydroxide solution, heat up to 105°C, Reaction 3.5h, obtain monoesterification product, the weight ratio of above-mentioned pimelic acid and epoxy dodecane is 1:1.2;

[0044] (2) Mix the monoesterification product with dodecyl heptapolyethylene glycol monoether, add concentrated sulfuric acid and organic solvent tetrahydrofuran, and then perform a condensation reaction at a temperature of 100°C and a stirring rate of 800r / min for 8 hours, and the reaction solution Cool to room temperature, add 30wt% saturated sodium bicarbonate solution to neutralize unreacted p-toluenesulfonic acid, extract the mixture with dichloromethane, combine the organic phases, and then successively wash with saturated NaHCO 3 solution, wa...

Embodiment 2

[0047] A kind of preparation method of ultrahigh partition coefficient composite iodine solution, its concrete steps are as follows:

[0048] (1) Place 5 times the amount of toluene after suberic acid is mixed with epoxyoctane, then add 2.5wt% chromium acetate and 35wt% concentration of 55% potassium hydroxide solution, heat up to 125 ° C, react 2.5h, obtain monoesterification product, the weight ratio of above-mentioned suberic acid and epoxy octane is 1:1.3;

[0049] (2) Mix the mono-esterification product with hexaethylene glycol monododecyl ether, add concentrated sulfuric acid and organic solvent tetrahydrofuran, then condense at a temperature of 110°C and a stirring rate of 1000r / min for 7.5h, and cool the reaction solution to At room temperature, add 30wt% saturated sodium bicarbonate solution to neutralize unreacted p-toluenesulfonic acid, extract the mixture with dichloromethane, combine the organic phases, and then successively wash with saturated NaHCO 3 solution, ...

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Abstract

The invention provides an ultrahigh-partition-coefficient composite iodine solution and a preparation method thereof, and belongs to the technical field of disinfectant preparation. The composite iodine solution is prepared from iodine, iodide or iodate, a nonionic surfactant, hydrochloric acid, phosphoric acid, and the balance of purified water. The preparation method comprises the following steps: dissolving the nonionic surfactant in hydrochloric acid, stirring, sequentially adding the iodine and the iodide or iodate, continuously stirring to obtain an iodine/nonionic surfactant complexingsolution, adding the phosphoric acid and purified water into the complexing solution, and stirring to obtain a reddish brown viscous liquid, namely the composite iodine solution. The composite iodinesolution can enhance the stability and dispersity of iodine-iodine ion composite particles, so that the storage stability of composite iodine is enhanced, and the loss rate of effective iodine is controlled to be 10% or below; the distribution coefficient can reach 1300 to 1500; and the penetration sterilization performance is strong, the safety is high, the water solubility is good, and the product quality is excellent.

Description

technical field [0001] The invention belongs to the technical field of disinfectant preparation, and in particular relates to an ultra-high partition coefficient composite iodine solution and a preparation method thereof. Background technique [0002] At present, it is the general trend to carry out intensive, scientific and ecological breeding process, and the country has also begun to attach great importance to the sustainable development of the combination of environmentally friendly breeding and ecological agriculture; a large number of studies have shown that in order to achieve this sustainable development, it is necessary to Only by changing the aspects of animal disease prevention, production mode, and production management can we realize the pollution-free green meat strategy. With the increasing scale and intensification of aquaculture, the stocking density of aquaculture animals is increasing, resulting in higher and higher morbidity rates and more complex disease...

Claims

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Application Information

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IPC IPC(8): A01N25/30A01N59/12A01P3/00A01P1/00A01P15/00
CPCA01N25/30A01N59/12
Inventor 钱立云孟令庄张荣连杨清芳赵兴鑫宋冠杰
Owner 河北华邦生物科技有限公司
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