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Biodegradable injection filler as well as preparation method and application thereof

A biodegradable polymer technology, applied in biodegradable injection fillings and its preparation and application fields, can solve the problems of PLLA adverse reactions, limited application range, prone to sedimentation and delamination, etc.

Inactive Publication Date: 2020-05-15
BEIJING SIHUAN PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 2. PLLA injection can cause adverse reactions, and there are potential safety hazards
PLLA is degraded into lactic acid in the body to form an acidic microenvironment, which in turn causes redness, ecchymosis, bruising, edema, papules, visible nodules, periorbital nodules, hardening of the injection area, abscesses, allergic reactions, urticaria, skin hypertrophy and atrophy, angioedema, telangiectasia, skin sarcoidosis, scarring, skin discoloration and other adverse reactions, limiting its scope of application
[0008] 3. The redispersibility of the freeze-dried product after reconstitution needs to be improved, and it is prone to sedimentation and stratification, which makes the injection operation inconvenient
However, the amount of hyaluronic acid in the mixed gel is relatively large, which increases injection irritation and adverse reactions

Method used

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  • Biodegradable injection filler as well as preparation method and application thereof
  • Biodegradable injection filler as well as preparation method and application thereof
  • Biodegradable injection filler as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0157] Example 1 Preparation of PLLA polymer

[0158] Add 500g of L-lactide to a 2000mL single-necked bottle, and heat it to 130°C under nitrogen protection. After the L-lactide is completely melted, add 0.15g of stannous isooctanoate and 1.5g of lauryl alcohol, and keep warm at 130°C React for 24 hours, after cooling the reaction solution to room temperature, add 1L of dichloromethane, stir to dissolve, filter, transfer the resulting solution to a 50L reaction kettle, add 4L of dichloromethane, dropwise add 25L of methanol, crystallize at room temperature, filter, The filter cake was dried at 50°C to obtain PLLA polymer with a weight average molecular weight of 36,000.

Embodiment 2

[0159] Example 2 Preparation of PLLA polymer

[0160] Add 500g of L-lactide to a 2000mL single-necked bottle, and heat it to 120°C under nitrogen protection. After the L-lactide is completely melted, add 0.1g of stannous chloride and 1.2g of lauryl alcohol, and keep the reaction at 120°C. After 48 hours, after the reaction solution was lowered to room temperature, 1 L of chloroform was added, stirred and dissolved, filtered, the solution was transferred to a 50 L reaction kettle, 4 L of chloroform was added, 25 L of n-heptane was added dropwise, crystallized at room temperature, filtered, The filter cake was dried at 50°C to obtain PLLA polymer with a weight average molecular weight of 39,000.

Embodiment 3

[0161] Example 3 Preparation of PLLA polymer microparticles

[0162] Weigh 200 g of the PLLA polymer prepared in Example 1, add 4 L of tetrahydrofuran, stir to dissolve, slowly add 12 L of anhydrous methanol dropwise, after the dropwise addition, stir for about 1 hour, filter, and rinse the filter cake with anhydrous methanol, Vacuum-dried at 35°C and passed through a 200-mesh sieve to obtain PLLA microparticles with a heat of fusion of 54.3J / g. The particle size distribution is shown in Figure 1.

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Abstract

The invention provides biodegradable polymer microparticles and a preparation method thereof. The polymer microparticles is a copolymer of lactic acid and / or glycolic acid repeating unit, and the particle sizes of the polymer microparticles are 10 micrometers to 150 micrometers. The PLLA microparticles disclosed by the invention has an irregular, unsmooth or rough microscopic shape, so that the contact area of the PLLA particles and cells is increased, the adhesion ability and the retention time of the cells on a porous structure or a scaffold structure are improved and prolonged, and the cellaffinity performance of the PLLA particles is obviously improved; the biodegradable polymer microparticles are beneficial for stimulating collagenocyte to feel physical and mechanical micro-environment stimulation and make a response, so that growth of collagen of a human body is further stimulated, and the effects of removing wrinkles, maintaining beauty and delaying aging are natural and lasting.

Description

technical field [0001] The invention relates to a biodegradable injection filler, a preparation method and an application thereof. Background technique [0002] Medical Cosmetology (Medical Cosmetology) refers to the use of drugs, surgery, medical equipment and other traumatic or irreversible medical technology methods to repair and reshape the appearance of people and the shape of various parts of the human body. With the advancement of science and technology and the continuous improvement of people's living standards, the public is more concerned about quality of life issues such as facial wrinkles and anti-aging. The "2015-2020 China Medical Beauty Industry Market Size and Growth Report" released by the Ministry of Commerce shows that the scale of China's medical beauty market continues to grow. In 2018, China's medical beauty market reached 224.5 billion yuan, accounting for 10% of the global medical beauty market. %, becoming the third largest market in the world for m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/50A61L27/58
CPCA61L27/18A61L27/20A61L27/50A61L27/58A61L2400/06A61L2430/02A61L2430/10A61L2430/38C08L67/04C08L5/16
Inventor 牛玉乐冯斌孙会谦王志军张景鹏孙国涛范建国甄志彬邓声菊徐艳君王田园夏洋
Owner BEIJING SIHUAN PHARMA
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