Production method for oxytetracycline dihydrate

Abstract

The invention discloses a production method for oxytetracycline dihydrate. The production method comprises the following steps: seed culture, fermentation culture, acidifying treatment, decoloring treatment, crystallizing treatment and drying treatment, wherein the crystallizing treatment comprises the following steps: heating the temperature of a decolored solution obtained through the decoloringtreatment to 28 DEG C to 32 DEG C through a preheater, then, inputting the heated decolored solution to a mixing tank, and meanwhile, starting up an alkalizing system to add an alkalizer into the mixing tank, so as to maintain a pH value of material liquid in the mixing tank to 4.4 to 4.8; and then, enabling the material liquid to overflow into a crystallizing tank for crystallization, wherein obtained crystallizing liquid flows into a crystallization buffer tank. The product yield is directly affected by a crystallizing temperature, a holding temperature is subjected to automated control during crystallization, a temperature is prevented from being deviated from a range during heat preservation, and a heat-preserving temperature is stable, so that the product yield can be further increased; and the accuracy of the pH value is the most important process control point of crystallization and directly affects the quality of the finished product, the adjusting of pH is more accurate, impurity precipitates in the crystallizing liquid are reduced, and the product quality is improved.

Description

technical field [0001] The invention relates to a production method of oxytetracycline base, which belongs to the field of extraction of antibiotic raw materials. Background technique [0002] Oxytetracycline is a broad-spectrum antibiotic, which has inhibitory effects on Gram-positive bacteria and Gram-negative bacteria, and also has certain inhibitory effects on Chlamydia, Rickettsia, Mycoplasma, Spirochetes, etc. Oxytetracycline is mainly used to prevent and control livestock and poultry Escherichia coli, Salmonella infection (such as calf pullorum, lamb dysentery, piglet yellow and white diarrhea, young animal paratyphoid, etc.), Pasteurella, Brucella infection, swine panting disease, chicken chronic respiratory disease It is also commonly used to treat rickettsial disease in dogs, infectious anemia in cats, and prevent chlamydial disease and spirochetal disease in dogs; it is also used locally for endometritis and tissue necrosis caused by necroptosis. [0003] The oxy...

AI Technical Summary

Problems solved by technology

In this method, the titer, transmittance, and pH of the continuously input crystallized decolorizing solution in different time periods in step e) are different, and continuous detection cannot be realized when the pH value is manually adjusted, and sudden highs will occur during the pH adjustment process. The phenomenon that the sudden drop cannot be corrected in time, resulting in the final crystallization product having a darker color when the pH is high, and a lighter color when the pH is low, and the product color is uneven; in addition, the crystallization is not complete when the pH is low, which affects the yield.

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