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Hyaluronic acid slow-release filler and preparation method thereof

A technology of hyaluronic acid and sodium hyaluronate, applied in the fields of biological materials and medical cosmetology, can solve the problems of easy formation of depressions or collapses, limited effect of collagen regeneration, insufficient tissue support, etc., so as to reduce the number of injections and save money. time and cost reduction

Active Publication Date: 2020-05-22
湖北翎美生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, after this method is implanted, the surfactant is quickly absorbed, resulting in a decrease in the overall volume, and the surface area of ​​the solid microspheres is small, so the effect of stimulating collagen regeneration is limited, and multiple injections are required to maintain the effect, although prolonged Degradation time, but also increased treatment times and costs
Moreover, absorbable polymer materials are often isovolumetrically degraded. After the microspheres are completely degraded, gaps are formed at the injection site, and tissue cells have no time to grow in and are filled with interstitial fluid, resulting in insufficient support of the tissue at the filling site, and easy to form depressions or collapses.

Method used

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Examples

Experimental program
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preparation example Construction

[0037] There are many methods for preparing absorbable polymer porous microspheres, such as: double emulsion solvent evaporation method, suspension polymerization method, dispersion polymerization method, seed swelling method, microfluidic polymerization method, etc., in a number of patent documents and articles Both are recorded. The invention adopts the disclosed double emulsion solvent volatilization method to prepare porous microspheres.

[0038] The absorbable polymer porous microspheres can be PCL porous microspheres, or can be replaced by PLA, PLGA, PGA, PVA, P-TMC and other in vivo degradable or water-soluble polymer materials;

[0039] Only one type of cross-linked sodium hyaluronate and small molecule sodium hyaluronate can be added, and can be replaced by water-soluble and biocompatible surfactants / density-increasing agents such as CMC, MC, and Tween;

[0040] PBS buffer can be replaced by normal saline, growth factors and other nutrients can be added, lidocaine an...

Embodiment 1

[0044] Embodiment 1 prepares PCL microsphere porous microsphere, and its specific surface area reaches 318m 2 / g

Embodiment 2

[0045] Embodiment 2 prepares PLA microsphere porous microsphere, and its specific surface area reaches 238m 2 / g

[0046] Example 1:

[0047] PCL porous microspheres are used as absorbable polymer porous microspheres. The formula is as follows:

[0048] The mass ratio is 30%, the particle size is 25-50 microns, the PCL porous microspheres with an average pore size of 1 micron, 1% cross-linked sodium hyaluronate, 2% small molecule sodium hyaluronate, and 67% PBS buffer configuration Injectable filling products, the external sodium hyaluronate slowly degrades and forms collagen outside the microspheres, and the sodium hyaluronate in the pores slowly degrades, inducing collagen fibers to grow into the pores and form a scaffold-like structure, and finally PCL Porous microspheres degrade slowly. The small molecule sodium hyaluronate on the outside of the microspheres degrades completely within 2 months, the cross-linked sodium hyaluronate outside and inside the pores of the mic...

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PUM

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Abstract

The invention discloses hyaluronic acid slow-release filler and a preparation method thereof. The invention aims to solve the problem that absorbable injection filler has a short maintenance time andno effects of long-term filling in the field of medical aesthetics. Absorbable high-molecular polymer porous microspheres are added to an original injection system so as to form a gradient degradationformula, the microporous structure is filled with cross-linked sodium hyaluronate through a unique technology, the tissue is stimulated to produce collagen fiber by the microporous structure during gradual degradation of the cross-linked sodium hyaluronate in micropores so that a network structure is formed, and finally a filling effect can still be achieved after the polymer molecules are degraded.

Description

technical field [0001] The invention relates to the field of medical cosmetology, in particular to a novel sodium hyaluronate sustained-release filling material and a preparation method thereof, and also to the field of biological materials. Background technique [0002] Absorbable material is a polymer material that can be enzymatically or hydrolyzed into carbon dioxide and water by the human body and finally absorbed by the human body. Due to its excellent mechanical properties, easy processing performance and biocompatibility, it is widely used in the field of medicine. [0003] Hyaluronic acid and collagen are commonly used cosmetic injection filling materials. Although these two materials have a low probability of sensitization, they are widely used due to their functions such as absorbability, promotion of tissue repair, and excellent biocompatibility. Medical beauty industry. However, the absorption time of these two materials is short, and they can only last for a...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/18A61L27/50A61L27/56A61L27/58
CPCA61L27/20A61L27/18A61L27/50A61L27/56A61L27/58A61L2400/06C08L5/08C08L67/04
Inventor 陶翠娥
Owner 湖北翎美生物科技有限公司
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