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Enteral slow-release sugar alcohol additive as well as preparation method and application thereof

A technology of slow-release sugar alcohols and additives, which is applied in the field of preparation of intestinal sustained-release products, can solve problems such as inability to fix the point, disorder of liver metabolism, unstable acid production, etc., and achieve the effect of achieving stability

Active Publication Date: 2020-06-16
ZHEJIANG HUAKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But neither fructo-oligosaccharide nor polysaccharide can synthesize propionic acid at fixed point and high concentration
The intestinal utilization rate of polysaccharides is not high, and it is easy to cause problems such as flatulence
Fructose-oligosaccharides can also cause excessive gas production, unstable acid production, and even excessive fructose, which can lead to liver metabolic disorders

Method used

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  • Enteral slow-release sugar alcohol additive as well as preparation method and application thereof
  • Enteral slow-release sugar alcohol additive as well as preparation method and application thereof
  • Enteral slow-release sugar alcohol additive as well as preparation method and application thereof

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preparation example Construction

[0024] The present invention also discloses a preparation method of the aforementioned enteral slow-release sugar alcohol additive, comprising the following steps:

[0025] Step 1, mix xylitol and agar, sterilize, put into ball-shaped abrasives and let stand to cool to make xylitol agar pellets.

[0026] Step 2, preparing carrageenan solution or gellan gum solution or xanthan gum solution or guar gum solution, adding vitamin B12 and L-arabinose to carrageenan solution or gellan gum solution or xanthan gum solution or guar mixing in the bean gum solution to obtain a mixed solution, and then wrapping the mixed solution with the xylitol agar pellet in step 1 to obtain a two-layer colloidal pellet of xylitol agar wrapped with the mixed solution.

[0027] Step 3. Place the two-layer colloidal beads prepared in step 2 in fermented Bifidobacterium culture fluid or fermented Propionibacterium culture fluid or fermented Lactobacillus culture fluid for cultivation, take out after cultiv...

Embodiment 1

[0030] The embodiment of the preparation method of the first enteral slow-release sugar alcohol additive of the present invention comprises the following steps:

[0031] Step 1. Weigh a certain amount of xylitol and mix it with 2% agar, and sterilize it at 121°C for 15 minutes. Let it cool down to make xylitol agar pellets.

[0032] Step 2. Weigh 2g of carrageenan, dissolve it in 100mL of distilled water, sterilize at 121°C for 15 minutes, wait to cool to 50°C~60°C, the temperature is not higher than 60°C, which is convenient for the stabilization of vitamin B12, avoid light, sterile L-Arabic Sugar and vitamin B12 are added to the carrageenan solution according to the mixing formula ratio of 1:0.005 and mixed evenly, and wrapped in xylitol agar pellets in a sterile ultra-clean table to make a two-layer colloid with a formula ratio of 1~33:1:0.005 small ball.

[0033] Step 3, add the two-layer colloidal pellets prepared in step 2 into the bifidobacterium fermentation accordin...

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Abstract

The invention relates to an enteral slow-release sugar alcohol additive. The enteral slow-release sugar alcohol additive comprises two layers of structures, wherein the inner-layer structure comprisescomponents of xylitol and agar, and the outer-layer structure comprises components of carrageenan or gellan gum or xanthan gum or guar gum, vitamin B12, L-arabinose and fermented bifidobacterium or fermented propionibacterium or fermented lactobacillus. The invention further discloses a method for preparing the enteral slow-release sugar alcohol additive and application of the enteral slow-release sugar alcohol additive. The xylitol, the L-arabinose and the vitamin B12 which are compounded are used, so that directional regulation and control of intestinal microorganisms are realized, and high-concentration synthesis of the propionic acid in intestines is realized.

Description

technical field [0001] The invention belongs to the technical field of preparation of intestinal sustained-release products, in particular to an intestinal slow-release sugar alcohol additive and its preparation method and application. Background technique [0002] After being absorbed, propionic acid is mainly metabolized in the liver, participates in gluconeogenesis, and inhibits cholesterol synthesis. However, various studies have shown that the effect of exogenous intake and self-produced propionic acid is not the same. External propionic acid It has important effects on many metabolic processes of the individual. Propionate is a short-chain fatty acid. Under normal circumstances, microorganisms in the human body can produce propionate by fermenting incompletely digested carbohydrates in the colon. These propionates are beneficial to the human body. However, exogenous propionic acid can lead to hyperglycemia and insulin in the short term, and long-term intake will cause...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/125A23L33/135A23L33/15A23P20/12
CPCA23L33/15A23L33/125A23L33/135A23P20/12A23V2002/00A23V2250/6422A23V2250/602A23V2250/706A23V2200/328A23V2200/3262A23L29/256A23L29/272A23L29/269A23L29/238Y02A50/30A23L29/37A23P20/15A61K31/047A61K31/7004A61K31/714A61K35/747A61K47/36
Inventor 向沙沙朱炫石丽华叶昆李勉
Owner ZHEJIANG HUAKANG PHARMA
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