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Multi-functional inorganic nanometer glue and preparation method thereof

An inorganic nano, multifunctional technology, used in medical science, surgery, surgical adhesives, etc.

Active Publication Date: 2020-07-10
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the multi-element doping of degradable MSN and its application as a nanoglue for various tissue adhesive repairs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0051] The present invention also provides a preparation method of the multifunctional nano glue, wherein the preparation steps of the degradable mesoporous silica SS-MSN nano glue are as follows:

[0052] Step 1. Preparation of degradable silica SS-SN: Dissolve cationic surfactant and sodium hydroxide in water, the concentration of cationic surfactant is 0.01-10% wt / v, and the concentration of sodium hydroxide is 0.01- 10%wt / v; add dropwise a mixture of disilicate and orthosilicate containing disulfide bonds, V in the mixture 含有二硫键的硅酸酯 :V 正硅酸酯 For (0.005~0.95):1, the total concentration of the mixed solution in the cationic surfactant and sodium hydroxide aqueous solution is 0.05-20% v / v; react at 50-100°C for 0.5-72h, successively water and anhydrous Wash with ethanol, centrifuge to collect the precipitate, and vacuum dry to obtain solid powder SS-MSN;

[0053]Step 2. Preparation of degradable mesoporous silica SS-MSN: redisperse the solid powder SS-SN in an organic solven...

example 1

[0068] First, dissolve 1% wt / v cetyltrimethylammonium bromide in deionized water, and add 0.5% wt / v sodium hydroxide to provide an alkaline environment, stir at 50°C until completely dissolved, then add 1 %wt / v copper nitrate and 3%wt / v magnesium nitrate solution, then slowly dropwise add orthosilicate and bis-(triethoxysilylpropyl) disulfide (volume ratio 1:1, total concentration 3 %v / v), continue to stir the product obtained by the reaction, wash thoroughly with deionized water and ethanol respectively after centrifugation; use 10%wt / v ethanol solution containing ammonium nitrate to extract and reflux for 24h to remove hexadecyl trimethyl bromide Ammonium chloride, after centrifugation, fully washed with deionized water and absolute ethanol, and vacuum dried overnight; prepared a 10% wt / v PBS solution to obtain copper and magnesium two-element doped SS-MSN nano glue.

example 2

[0070] Dissolve 10% wt / v dodecyltrimethylammonium bromide in deionized water, and add 5% wt / v sodium hydroxide to provide an alkaline environment, stir at 80°C until completely dissolved, then immediately add 0.1 %wt / v copper nitrate, 0.2% wt / v strontium nitrate and 1.2% wt / v cerium nitrate solution, then slowly dropwise add tetraethoxy-3,18 -Dioxin-10,11-dithio-4,17-disilaicosane (volume ratio 7:3, total concentration 7% v / v), continue to stir the reaction product, centrifuge and use Fully washed with deionized water and ethanol; extracted and refluxed for 8h with a mixed solution containing hydrochloric acid and ethanol (50%wt / v) to remove dodecyltrimethylammonium bromide, and the product was fully cleaned with deionized water and absolute ethanol, Vacuum dry overnight; prepare a 20% wt / v culture medium solution to obtain copper, strontium, and cerium three-element doped SS-MSN nano glue.

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Abstract

The invention provides multi-functional inorganic nanometer glue and a preparation method thereof. Biodegradable nanometer particles of which the concentration is 0.2-50%wt / v is added to a solvent, and are element doped mesoporous silicon nanometer particles SS-MSN or element doped mesoporous bioactive glass MBG, containing disulfide bonds, and the solvents include but are not limited to ultra pure water, PBS or a cell culture medium. The prepared glue has favorable biocompatibility, is high in binding strength with biological tissue and biodegradable, can realize multiple functions of resisting bacteria, resisting inflammation, adjusting and controlling ROS, promoting vascularization and the like, can accelerate wound healing, and can be applied to the biopharmaceutical field but not limited to adhesion and repair of skin, oral cavities, internal organs, intestines and meninges.

Description

technical field [0001] The invention relates to a nanometer glue and a preparation method thereof, which is used to solve the problem of single biological function of the existing tissue adhesive, and belongs to the technical field of biological materials. Background technique [0002] With the advent of the era of "trauma cosmetology", people not only require the wound to be closed quickly, but also require the elimination of scars. Traditional cosmetic sutures can minimize scarring, but consume a lot of time for the surgeon. In the past ten years, the emergence of tissue adhesives is expected to solve the above problems, and can effectively replace surgical sutures or staples for tension-free wound bonding, that is, first use absorbable sutures for subcutaneous suture to eliminate wound tension, and then use tissue Adhesives replace surgical sutures to bond the superficial skin, which can effectively eliminate scars. Compared with surgical sutures, tissue adhesives have ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/02A61L24/00
CPCA61L24/02A61L24/0042A61L24/001A61L24/0036
Inventor 崔宁
Owner NORTHWESTERN POLYTECHNICAL UNIV
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