Application of chlorogenic acid in preparation of medicine or pharmaceutical composition for preventing or treating pain

A technology of composition and chlorogenic acid, which is applied in the direction of drug combination, drug delivery, antipyretics, etc., can solve the problems of three-step analgesic drug adverse reactions, achieve good clinical application prospects, have no toxic side effects, and relieve cancer pain Effect

Inactive Publication Date: 2020-07-21
SICHUAN JIUZHANG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, there are also serious adverse effects of the three-step pain relief drug (opioids and NSAIDs)

Method used

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  • Application of chlorogenic acid in preparation of medicine or pharmaceutical composition for preventing or treating pain
  • Application of chlorogenic acid in preparation of medicine or pharmaceutical composition for preventing or treating pain
  • Application of chlorogenic acid in preparation of medicine or pharmaceutical composition for preventing or treating pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1 Oral pharmaceutical preparation prescription of the present invention

[0046] 1. Prescription 1

[0047] Chlorogenic acid 1000g.

[0048] Preparation method: aseptically weigh chlorogenic acid, and aseptically pack into powder.

[0049] 2. Prescription II

[0050] Chlorogenic acid 1000g, filler 500g, binder 5g.

[0051] Preparation method: Weigh chlorogenic acid, fillers, and binders according to the prescription, granulate, granulate, and pack into granules.

[0052] 3. Prescription Three

[0053] Chlorogenic acid 1000g, filler 500g, binder 5g, lubricant 3g.

[0054] Preparation method: Weigh chlorogenic acid, filler and binder according to the prescription, granulate, granulate, add lubricant, compress into tablets to obtain tablets.

[0055] The above-mentioned filler is one or more of mannitol, lactose, starch, microcrystalline cellulose, and dextrin; the binder is sodium carboxymethyl cellulose, PVP; the lubricant is magnesium stearate, talcum p...

Embodiment 2

[0056] Embodiment 2 injection preparation prescription of the present invention

[0057] 1. Prescription 1

[0058] Chlorogenic acid 1000g.

[0059] Preparation method (1): Aseptically weigh chlorogenic acid according to the prescription, and aseptically subpackage it into powder injection.

[0060] Preparation method (2): Weigh chlorogenic acid according to the prescription, dissolve in water for injection, filter and sterilize, freeze-dry, and fill to obtain freeze-dried powder injection.

[0061] 2. Prescription II

[0062] Chlorogenic acid 1000g, scaffold agent 2667g, antioxidant 67g.

[0063] Preparation method: Weigh chlorogenic acid, scaffolding agent, and antioxidant according to the prescription, dissolve in water for injection, filter and sterilize, fill, and freeze-dry to obtain freeze-dried powder injection.

[0064] The above-mentioned support agent is mannitol, lactose, and glucose; the antioxidant is sodium bisulfite, vitamins, glutathione, and folic acid. ...

Embodiment 3

[0065] Example 3 Chlorogenic Acid Prevention or Treatment of Rat Bone Cancer Pain Animal Experiments

[0066] 1. Test material

[0067] 1.1 Animals

[0068] SD rats, female, weighing 180-200 g, were purchased from Chengdu Dashuo Experimental Animal Co., Ltd.

[0069] 1.2 Cell lines

[0070] Walker mouse breast cancer cell line was purchased from Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

[0071] 1.3 Drugs

[0072] Chlorogenic acid, batch number: 171101, content 99.83%, prepared by Sichuan Jiuzhang Biotechnology Co., Ltd.

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PUM

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Abstract

The invention provides application of chlorogenic acid in preparation of medicine or pharmaceutical composition for preventing or treating pain. The pain comprises cancer pain, skeletal muscle pain and the like. The invention further provides a medicine for preventing or treating pain, and the medicine is a pharmaceutical preparation prepared by taking chlorogenic acid as an active ingredient andadding pharmaceutically acceptable auxiliary materials. The medicine provided by the invention can effectively relieve cancer pain and bone joint pain, and has no toxic or side effect; the pharmaceutical composition can replace analgesic drugs such as opioid drugs and non-steroidal anti-inflammatory drug treatment, avoids toxic and side addiction caused by long-term use of the opioid drugs, improves the survival quality of patients, and has good clinical application prospects.

Description

technical field [0001] The invention relates to the field of pain-related medicines, in particular to the use of chlorogenic acid in the preparation of medicines or pharmaceutical compositions for preventing or treating pain. Background technique [0002] Pain is a complex and common clinical symptom and disease that reflects subjective emotional feelings. In 1979, the International Association for the Study of Pain (IASP) defined pain as an unpleasant subjective sensory and emotional experience associated with tissue damage or potential tissue damage. In 2016, the definition of pain was updated as follows: Pain is a painful experience caused by actual or potential tissue damage with sensory, emotional, cognitive and social levels. In 1985, the American Pain Society proposed that pain is the fifth vital sign after heart rate, blood pressure, pulse and respiration. [0003] The classification of pain is relatively complicated. In 1994, the IASP classified pain according to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P29/00A61P35/00A61P19/02A61P21/00A61P25/00A61P37/02
CPCA61K31/216A61P29/00A61P35/00A61P19/02A61P21/00A61P25/00A61P37/02A61K9/08A61K9/0019A61K9/205A61P25/04
Inventor 张洁张亚卓姬勋黄望
Owner SICHUAN JIUZHANG BIO TECH CO LTD
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